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Home › Research › Topics › design-synthesis

design-synthesis

2 studies tagged design-synthesis, dated 2004-11-01 to 2014-01-27. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease 2014-01-27
  2. Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues 2004-11-01

Studies

2 studies carry this tag.

Date range

2004 to 2014

Top journals

  • European journal of medicinal chemistry 1
  • Journal of medicinal chemistry 1

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. European journal of medicinal chemistry 2014-01-27 Treatments

    The design, synthesis, and pharmacological evaluation of donepezil-indolyl based amines 7-10, amides 12-16, and carboxylic acid derivatives 5 and 11, as multipotent ASS234 analogs, able to inhibit simultaneously cholinesterase (ChE) and monoamine oxidase (MAO) enzymes for the potential treatment of Alzheimer's disease (AD), is reported.

  2. Design, synthesis, and biological evaluation of conformationally restricted rivastigmine analogues

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of medicinal chemistry 2004-11-01 Treatments

    Rivastigmine (1), an acetylcholinesterase (AChE) inhibitor approved in 2000 for the treatment of Alzheimer disease, bears a carbamate moiety in its structure, which is able to react covalently with the active site of the enzyme.

All topic tags with their study counts