alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Home › Research › Topics › blood-brain-barrier

blood-brain-barrier

229 studies tagged blood-brain-barrier, dated 1986-03-01 to 2026-10-24. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Serpin A3 is Increased in Cerebral Amyloid Angiopathy and ARIA 2026-10-24
  2. Endothelial CD36 links arteriolar remodeling to metabolic and immune alterations in Alzheimer’s disease 2026-10-14
  3. Location-specific Longitudinal Patterns of Subcortical and Lobar Cerebral Microhemorrhages in Preclinical Alzheimer Disease 2026-10-13

Studies

229 studies carry this tag.

Date range

1986 to 2026

Top journals

  • Journal of Alzheimer's disease : JAD 13
  • International journal of molecular sciences 11
  • bioRxiv 11
  • Alzheimer's & dementia : the journal of the Alzheimer's Association 10
  • Molecular neurodegeneration 7

123 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Neurovascular dysfunction, inflammation and endothelial activation: implications for the pathogenesis of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of neuroinflammation 2011-03-25 Costs and economics

    Alzheimer's disease (AD) is an age-related disorder characterized by progressive cognitive decline and dementia.

  2. Engaging neuroscience to advance translational research in brain barrier biology

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Nature reviews. Neuroscience 2011-03-01 Tau biomarkers

    The delivery of many potentially therapeutic and diagnostic compounds to specific areas of the brain is restricted by brain barriers, of which the most well known are the blood-brain barrier (BBB) and the blood-cerebrospinal fluid (CSF) barrier.

  3. Pericyte-mediated regulation of capillary diameter: a component of neurovascular coupling in health and disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Frontiers in Neuroenergetics 2010-01-01 Vascular contributions

    Because regional blood flow increases in association with the increased metabolic demand generated by localized increases in neural activity, functional imaging researchers often assume that changes in blood flow are an accurate read-out of changes in underlying neural activity.

  4. Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuroscience 2009-01-19 Biomarkers

    The neurovascular unit (NVU) comprises cerebral blood vessels and surrounding astrocytes, neurons, perivascular microglia and pericytes.

  5. The blood-brain barrier in brain homeostasis and neurological diseases

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biochimica et biophysica acta 2008-11-11 Vascular contributions

    Brain endothelial cells are unique among endothelial cells in that they express apical junctional complexes, including tight junctions, which quite resemble epithelial tight junctions both structurally and functionally.

  6. Diffusion in brain extracellular space

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Physiological reviews 2008-10-01 Vascular contributions

    Diffusion in the extracellular space (ECS) of the brain is constrained by the volume fraction and the tortuosity and a modified diffusion equation represents the transport behavior of many molecules in the brain.

  7. Multiplicity of cerebrospinal fluid functions: New challenges in health and disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Cerebrospinal fluid research 2008-05-14 Tau biomarkers

    Accordingly the altered CSF composition in neurodegenerative diseases and senescence, because of adverse effects on neural processes and cognition, needs more effective clinical management.

  8. Ultrasound enhanced delivery of molecular imaging and therapeutic agents in Alzheimer's disease mouse models

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. PloS one 2008-05-14 Treatments

    Alzheimer's disease is a neurodegenerative disorder typified by the accumulation of a small protein, beta-amyloid, which aggregates and is the primary component of amyloid plaques.

  9. Solutes, but not cells, drain from the brain parenchyma along basement membranes of capillaries and arteries: significance for cerebral amyloid angiopathy and neuroimmunology

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuropathology and applied neurobiology 2008-01-16 Vascular contributions

    Elimination of interstitial fluid and solutes plays a role in homeostasis in the brain, but the pathways are unclear.

  10. The blood-brain barrier in health and chronic neurodegenerative disorders

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuron 2008-01-01 Inflammation and the immune system

    The blood-brain barrier (BBB) is a highly specialized brain endothelial structure of the fully differentiated neurovascular system.

  11. Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2006-11-22 Vascular contributions

    The molecular mechanism underlying the pathogenesis of the majority of cases of sporadic Alzheimer's disease (AD) is unknown.

  12. Blood-brain barrier: structural components and function under physiologic and pathologic conditions

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2006-07-06 Inflammation and the immune system

    The blood-brain barrier (BBB) is the specialized system of brain microvascular endothelial cells (BMVEC) that shields the brain from toxic substances in the blood, supplies brain tissues with nutrients, and filters harmful compounds from the brain back to the bloodstream.

  13. Perivascular nerves and the regulation of cerebrovascular tone

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of applied physiology (Bethesda, Md. : 1985) 2006-03-01 Vascular contributions

    Brain perfusion is tightly coupled to neuronal activity, is commonly used to monitor normal or pathological brain function, and is a direct reflection of the interactions that occur between neuronal signals and blood vessels.

  14. Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of applied physiology (Bethesda, Md. : 1985) 2006-01-01 Risk factors

    The brain is critically dependent on a continuous supply of blood to function.

  15. Quantification of cerebral amyloid angiopathy and parenchymal amyloid plaques with Congo red histochemical stain

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Nature protocols 2006-01-01 Treatments

    In the current protocol, we describe the Congo red staining method and a method for separately quantifying vascular and parenchymal amyloid deposits in brain tissue sections.

  16. Neurovascular mechanisms of Alzheimer's neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Trends in neurosciences 2005-04-01 Vascular contributions

    In contrast to traditional neuroncentric views of Alzheimer's disease (AD), recent findings indicate that neurovascular dysfunction contributes to cognitive decline and neurodegeneration in AD.

  17. Emerging Therapies for Vascular Dementia and Vascular Cognitive Impairment

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Stroke 2004-03-09 Treatments

    From a public health viewpoint, recognition of VCI before the development of dementia and correction of vascular burden on the brain may lead to a global decrease of incident dementia.

  18. Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. The Lancet. Neurology 2004-03-01 Vascular contributions

    The cause of Alzheimer's disease (AD) is unknown.

  19. Endothelial-pericyte interactions in angiogenesis

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Cell and tissue research 2003-07-22 Vascular contributions

    It takes two to make blood vessels-endothelial cells and pericytes.

  20. Alzheimer's disease and angiogenesis

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Lancet (London, England) 2003-02-01 Drug development

    Despite enormous investigative efforts, the pathological basis for Alzheimer's disease remains unclear.

  21. Molecular physiology and pathophysiology of tight junctions in the blood-brain barrier

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Trends in neurosciences 2001-12-01 Vascular contributions

    Disruption of the tight junctions (TJs) of the blood-brain barrier (BBB) is a hallmark of many CNS pathologies, including stroke, HIV encephalitis, Alzheimer's disease, multiple sclerosis and bacterial meningitis.

  22. Cerebral microvascular pathology in aging and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Progress in neurobiology 2001-08-01 Vascular contributions

    The aging of the central nervous system and the development of incapacitating neurological diseases like Alzheimer's disease (AD) are generally associated with a wide range of histological and pathophysiological changes eventually leading to a compromised cognitive status.

  23. Pericytes: Cell Biology and Pathology

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Cells Tissues Organs 2001-01-01 Vascular contributions

    Pericytes are perivascular cells with multifunctional activities which are now being elucidated.

  24. Cerebral amyloid angiopathy: an overview

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Neuropathology : official journal of the Japanese Society of Neuropathology 2000-03 Vascular contributions

    Cerebral amyloid angiopathy (CAA) is characterized by amyloid deposition in cortical and leptomeningeal vessels.

  25. Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Proceedings of the National Academy of Sciences 1999-11-23 Vascular contributions

    Transgenic mice that overexpress mutant human amyloid precursor protein (APP) exhibit one hallmark of Alzheimer's disease pathology, namely the extracellular deposition of amyloid plaques.

  26. Aging and cerebrovascular disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Neurologic clinics 1998-08 Vascular contributions

    Aging influences cerebrovascular disease expression by a variety of mechanisms.

  27. Pathological alterations of the cerebral microvasculature in Alzheimer's disease and related dementing disorders

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Acta neuropathologica 1994-01-01 Down syndrome and Alzheimer's

    In all dementing illnesses, increased microvascular pathology was evident compared to normal controls.

  28. Blood-brain barrier penetration and in vivo activity of an NGF conjugate

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Science (New York, N.Y.) 1993-01-01 Brain scans and imaging

    Nerve growth factor (NGF) is essential for the survival of both peripheral ganglion cells and central cholinergic neurons of the basal forebrain.

  29. A white matter disorder in dementia of the Alzheimer type: a pathoanatomical study

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Annals of neurology 1986-03-01 Vascular contributions

    In cases of Alzheimer's presenile and senile dementia, Alzheimer's disease (AD) and senile dementia of the Alzheimer type (SDAT), respectively, we have observed, in addition to the gray matter degeneration, a lesion that has the character of an incomplete infarction confined to the white matter.

From across this tag

7 of the 229 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 7. The same 7 appear here every time.

All topic tags with their study counts