alzhub.org
Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Home › Research › Topics › apoe2

apoe2

266 studies tagged apoe2, dated 1993-09-01 to 2026-10-27. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. ApoE4 and Psychosis in Neurodegenerative and Non-Neurodegenerative Disease: A Scoping Review 2026-10-27
  2. Multimodal mediators connecting APOE4 to dementia 2026-10-21
  3. Reproductive Aging, FSH, and Apolipoprotein Biology in Alzheimer’s Disease 2026-10-19

Studies

266 studies carry this tag.

Date range

1993 to 2026

Top journals

  • Neuron 11
  • The Journal of neuroscience : the official journal of the Society for Neuroscience 9
  • International journal of molecular sciences 8
  • Alzheimer's & dementia : the journal of the Alzheimer's Association 7
  • bioRxiv 6

168 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neuroepidemiology 1998-01-01 Genetics

    The epsilon 4 allele of the apolipoprotein E (apoE) is associated with Alzheimer's disease (AD) and also with elevated serum total cholesterol and low-density lipoprotein levels.

  2. Association of human, rat, and rabbit apolipoprotein E with beta-amyloid

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of neuroscience research 1997-07-01 Genetics

    In humans, apolipoprotein E (apoE) has three major isoforms, E2 (Cys112, Cys158), E3 (Cys112, Arg158), and E4 (Arg112, Arg158).

  3. ApoE-4 and Age at Onset of Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Neurology 1997-01-01 Genetics

    ApoE-4 was strongly associated with AD in this sample (allele frequency = 0.46 vs. 0.14 in controls, p < 0.000001).

  4. Herpes simplex virus type 1 in brain and risk of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Lancet (London, England) 1997-01-01 Genetics

    By multiple logistic regression, the APOE-epsilon 4 allele frequency was significantly higher in the patients positive for HSV1 in brain than in the HSV1-negative AD group, the HSV1-positive non-AD group, or the HSV1-negative non-AD group (52.8% vs 10.0%, 3.6%, and 6.3%, respectively).

  5. Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Nature genetics 1996-09-01 Genetics

    The apolipoprotein E (APOE) E4 allele is associated with Alzheimer's disease, cardiovascular disease, and decreased longevity.

  6. Crosslinking of apolipoprotein E by products of lipid peroxidation

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of neuropathology and experimental neurology 1996-02 Genetics

    Apolipoprotein E (APOE) genotype and advancing aging are interacting ri sk factors in the expression of late onset and sporadic Alzheimer's Disease (AD).

  7. Apolipoprotein E alleles as risk factors in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Annual review of medicine 1996-01-01 Genetics

    Alzheimer's disease (AD) is unique in medicine in that millions of people suffer from what appears to be the same form of disease, and unlike most other late-onset diseases, the genetic etiologies have been well identified.

  8. Apolipoprotein E and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Annual review of neuroscience 1996 Genetics

    The apolipoprotein E locus (APOE) is associated with variations in the age of onset and risk of Alzheimer's disease.

  9. Apolipoprotein E, synaptic plasticity and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Annals of medicine 1995-12 Genetics

    Apolipoprotein E (apoE) has been studied extensively with regard to its role in plasma lipoprotein lipid transport.

  10. Apolipoprotein E ϵ4 and cerebral hemorrhage associated with amyloid angiopathy

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Annals of Neurology 1995-08-01 Genetics

    Cerebral amyloid angiopathy (CAA) is characterized by cerebrovascular deposition of the amyloid beta-peptide, leading to intracerebral hemorrhage in severe cases.

  11. Apolipoprotein E genotype, Alzheimer's pathologies and related gene expression in the aged population

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Brain research. Molecular brain research 1995-03 Genetics

    We have investigated the effect of genotypes of apolipoprotein E (ApoE) on the pathologies found in Alzheimer's disease (AD) and its related gene expression in 38 aged human brains obtained from consecutive autopsied cases.

  12. Apolipoprotein E in animal models of CNS injury and in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Trends in neurosciences 1994-12-01 Genetics

    Recent evidence indicates that apolipoprotein E (ApoE) plays a central role in the hippocampal response to injury.

  13. Isoform-specific binding of apolipoprotein E to beta-amyloid

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of Biological Chemistry 1994-09-01 Genetics

    Apolipoprotein E (apoE), particularly the e4 allele, is genetically linked to the incidence of Alzheimer's disease.

  14. Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Science (New York, N.Y.) 1994-05-01 Genetics

    Apolipoprotein E4 (apoE4), one of the three common isoforms of apoE, has been implicated in Alzheimer's disease.

  15. Apolipoprotein E, ɛ4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer's disease: analysis of the 19q13.2 chromosomal region

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Human Molecular Genetics 1994-01-01 Genetics

    An association between the 19q13.2 chromosomal region and Alzheimer's disease (AD) has been reported in AD families and for sporadic AD.

  16. Apolipoprotein E polymorphism and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Lancet (London, England) 1993-09-01 Genetics

    Apolipoprotein E (apoE) is associated with Alzheimer's neurofibrillary tangles and beta-amyloid protein in senile plaques.

From across this tag

9 of the 266 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

All topic tags with their study counts