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Time-restricted feeding alters isoflurane-induced memory deficits
Jia Song, Shuaishuai Chu, Xin Fang, Fangxia Xu, Peng Zhang, Xin Zhao, Zhengliang Ma, Tianjiao Xia et al.. Translational Neuroscience, 2020-01-01
Topic: Brain proteins, microglia and lab models
Abstract Food consumption during the rest phase promotes circadian desynchrony, which is corrected with harmful physiological and mental disorders. Previously, we found that circadian desynchrony was involved in isoflurane-induced cognitive impairment. Here, we scheduled food access to modulate daily rhythm to examine its impact on isoflurane-induced cognitive impairments. Mice were randomly transferred to restricted feeding (RF) time groups: Control group (Zeitgeber time (ZT) 0–ZT24, ad libitum feeding), Day-Feeding group (ZT0–ZT12, misaligned feeding), and Night-Feeding group (ZT12–ZT24, aligned feeding). Then, some of them were subjected to 5 h of 1.3% isoflurane anaesthesia from ZT14 to ZT19 and were divided into the Control + Anes group, the Day-Feeding + Anes group, and the Night-Feeding + Anes group. Mini-Mitter was used to monitor the daily rhythm. Fear conditioning system was conducted to assess cognition of mice. We observed that the Night-Feeding group adapted to RF gradually, whereas the Day-Feeding group exhibited a disturbed daily rhythm. The Night-Feeding + Anes group exhibited a partially enhanced daily rhythm, whereas the Day-Feeding + Anes group exhibited sustained phase advances and diurnality score increase 7 days after isoflurane anaesthesia. Notably, in tests of hippocampus-dependent contextual memory, the Night-Feeding + Anes group demonstrated decreased deficits; the Day-Feeding + Anes group showed prolonged post-anaesthetic deficits 14 days after isoflurane anaesthesia. However, amygdala-dependent cued-fear conditioning post-anaesthesia was not altered by the RF schedule. In conclusion, we demonstrated that misaligned feeding disturbed the daily rhythm and led to persistent post-anaesthetic cognitive dysfunction. Aligned feeding enhanced the daily rhythm partially and improved post-anaesthetic cognitive dysfunction.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Song, J., Chu, S., Fang, X., Xu, F., Zhang, P., Zhao, X., et al. (2020). Time-restricted feeding alters isoflurane-induced memory deficits. Translational Neuroscience. https://doi.org/10.1515/tnsci-2020-0130
Vancouver
Song J, Chu S, Fang X, Xu F, Zhang P, Zhao X, et al. Time-restricted feeding alters isoflurane-induced memory deficits. Translational Neuroscience. 2020. doi:10.1515/tnsci-2020-0130. PMID: 33335774.
BibTeX
@article{song2020-33335774,
author = {Song, Jia and Chu, Shuaishuai and Fang, Xin and Xu, Fangxia and Zhang, Peng and Zhao, Xin and Ma, Zhengliang and Xia, Tianjiao and others},
title = {{Time-restricted feeding alters isoflurane-induced memory deficits}},
journal = {Translational Neuroscience},
year = {2020},
doi = {10.1515/tnsci-2020-0130},
pmid = {33335774},
url = {https://doi.org/10.1515/tnsci-2020-0130}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Previously, we found that circadian desynchrony was involved in isoflurane-induced cognitive impairment.
- We observed that the Night-Feeding group adapted to RF gradually, whereas the Day-Feeding group exhibited a disturbed daily rhythm.
- Notably, in tests of hippocampus-dependent contextual memory, the Night-Feeding + Anes group demonstrated decreased deficits; the Day-Feeding + Anes group showed prolonged post-anaesthetic deficits 14 days after isoflurane anaesthesia.
- In conclusion, we demonstrated that misaligned feeding disturbed the daily rhythm and led to persistent post-anaesthetic cognitive dysfunction.
Why it matters
In mice, feeding only during the active phase reduced memory deficits after isoflurane anaesthesia, while feeding during the rest phase prolonged them. This is animal research, so it does not yet show whether meal timing affects memory problems in people.
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Study details
- Effect size1.3%
- Evidence strengthLow
How this study scored 32/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Translational Neuroscience) |
| Journal's citation record | 0 / 4 | Translational Neuroscience: journal h-index 40 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 2 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.2 citations a year over 8 year(s) since 2020 |
| Impact for its field and year | 1 / 6 | Cited 0.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 1 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Xiaoping Gu: h-index 36 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Nanjing University: institution h-index 850 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 33335774) |
| Free to read | 2 / 2 | Free to read |
| Total | 32 / 100 | — |
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Read the original
- DOI: 10.1515/tnsci-2020-0130
- PubMed: 33335774
- Original source →
- Free full text: Translational Neuroscience →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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