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Risk of pneumonia in new users of cholinesterase inhibitors for dementia
Edward Chia-Cheng Lai, Monera B Wong, Isao Iwata, Yinghong Zhang, Cheng-Yang Hsieh, Yea-Huei Kao Yang, Soko Setoguchi. Journal of the American Geriatrics Society, 2015-04-27
Topic: Drug trials: efficacy and safety
The mean age of 35,570 new users of cholinesterase inhibitors (30,174 users of donepezil, 1,176 users of galantamine, 4,220 users of rivastigmine) was 82; 75% were women, and 82% were white. The cumulative incidence of pneumonia was 51.9 per 1,000 person-years. The risk of pneumonia for rivastigmine users was 24% lower than that of donepezil users (hazard ratio (HR)=0.75, 95% confidence interval (CI)=0.60-0.93). Risk in galantamine users (HR=0.87, 95% CI=0.62-1.23) was not significantly different from risk in donepezil users. Results of subgroup and sensitivity analyses were similar to the primary results. The risk of pneumonia was lower in individuals receiving rivastigmine than in those receiving donepezil. Additional studies are needed to confirm the findings of pneumonia risk between the oral and transdermal forms of rivastigmine and in users of galantamine.
Key findings
- The mean age of 35,570 new users of cholinesterase inhibitors (30,174 users of donepezil, 1,176 users of galantamine, 4,220 users of rivastigmine) was 82; 75% were women, and 82% were white.
- The cumulative incidence of pneumonia was 51.9 per 1,000 person-years.
- The risk of pneumonia for rivastigmine users was 24% lower than that of donepezil users (hazard ratio (HR)=0.75, 95% confidence interval (CI)=0.60-0.93).
- Risk in galantamine users (HR=0.87, 95% CI=0.62-1.23) was not significantly different from risk in donepezil users.
- Results of subgroup and sensitivity analyses were similar to the primary results.
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Study details
- Study designcohort study
- Effect sizeHR=0.87
- Evidence strengthModerate
How this study scored 59/100
Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for sample size, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 33 of the 56 points we could judge it on, which is 59 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of the American Geriatrics Society) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A cohort study following people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2015 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 25912671) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 33 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 33 of the 56 points we could judge it on is 59 out of 100. |
| Total | 59 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Lai, E. C.-C., Wong, M. B., Iwata, I., Zhang, Y., Hsieh, C.-Y., Yang, Y.-H. K., et al. (2015). Risk of pneumonia in new users of cholinesterase inhibitors for dementia. Journal of the American Geriatrics Society. https://doi.org/10.1111/jgs.13380
Vancouver
Lai EC.-C, Wong MB, Iwata I, Zhang Y, Hsieh C.-Y, Yang Y.-HK, et al. Risk of pneumonia in new users of cholinesterase inhibitors for dementia. Journal of the American Geriatrics Society. 2015. doi:10.1111/jgs.13380. PMID: 25912671.
BibTeX
@article{lai2015-25912671,
author = {Lai, Edward Chia-Cheng and Wong, Monera B and Iwata, Isao and Zhang, Yinghong and Hsieh, Cheng-Yang and Yang, Yea-Huei Kao and Setoguchi, Soko},
title = {{Risk of pneumonia in new users of cholinesterase inhibitors for dementia}},
journal = {Journal of the American Geriatrics Society},
year = {2015},
doi = {10.1111/jgs.13380},
pmid = {25912671},
url = {https://doi.org/10.1111/jgs.13380}
}
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