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50/100

✓ Peer-reviewed alzhub usefulness score 50 out of 100. How common it is

Topic: Risk, prevention and care in population studies

Among 360,014 individuals with psoriasis and 1,799,617 without, psoriasis was associated with a small increased risk of all-cause dementia (adjusted hazard ratio [aHR] 1.06, 95% CI 1.04-1.08; absolute rate difference 24 per 100,000 person-years). Strength of association increased with time since psoriasis diagnosis (e.g. aHR 0.99, 0.96-1.03 within 0 to 5 years; 1.20, 1.05-1.37 within 20 to 25 years). The association was stronger for vascular dementia (aHR 1.10, 1.06-1.14) than Alzheimer's dementia (aHR 1.03, 1.00-1.06). Hazard ratios were larger for severe psoriasis (all-cause aHR 1.32, 1.25-1.39; vascular aHR 1.58, 1.44-1.74; Alzheimer's aHR 1.11, 1.02-1.21). Long-term risk of all-cause dementia and vascular dementia, but not Alzheimer's dementia, was slightly higher in people with psoriasis, but absolute risk differences were small. Risks were more substantially raised with time since psoriasis diagnosis and in severe psoriasis compared to mild to moderate psoriasis, suggesting a potential dose-response relationship.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Matthewman, J., Mansfield, K. E., Cadogan, S. L., Abuabara, K., Smith, C., Bhaskaran, K., et al. (2025). Psoriasis and dementia: A population‐based matched cohort study of adults in England. Annals of Clinical and Translational Neurology. https://doi.org/10.1002/acn3.52283

Vancouver

Matthewman J, Mansfield KE, Cadogan SL, Abuabara K, Smith C, Bhaskaran K, et al. Psoriasis and dementia: A population‐based matched cohort study of adults in England. Annals of Clinical and Translational Neurology. 2025. doi:10.1002/acn3.52283. PMID: 39743756.

BibTeX

@article{matthewman2025-39743756,
  author  = {Matthewman, Julian and Mansfield, Kathryn Elizabeth and Cadogan, Sharon Louise and Abuabara, Katrina and Smith, Catherine and Bhaskaran, Krishnan and Langan, Sinéad and Warren‐Gash, Charlotte},
  title   = {{Psoriasis and dementia: A population‐based matched cohort study of adults in England}},
  journal = {Annals of Clinical and Translational Neurology},
  year    = {2025},
  doi     = {10.1002/acn3.52283},
  pmid    = {39743756},
  url     = {https://doi.org/10.1002/acn3.52283}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

Key findings

Among 360,014 individuals with psoriasis and 1,799,617 without, psoriasis was associated with a small increased risk of all-cause dementia (adjusted hazard ratio [aHR] 1.06, 95% CI 1.04-1.08; absolute rate difference 24 per 100,000 person-years).
Strength of association increased with time since psoriasis diagnosis (e.g. aHR 0.99, 0.96-1.03 within 0 to 5 years; 1.20, 1.05-1.37 within 20 to 25 years).
The association was stronger for vascular dementia (aHR 1.10, 1.06-1.14) than Alzheimer's dementia (aHR 1.03, 1.00-1.06).
Hazard ratios were larger for severe psoriasis (all-cause aHR 1.32, 1.25-1.39; vascular aHR 1.58, 1.44-1.74; Alzheimer's aHR 1.11, 1.02-1.21).
Long-term risk of all-cause dementia and vascular dementia, but not Alzheimer's dementia, was slightly higher in people with psoriasis, but absolute risk differences were small.

Why it matters

People with psoriasis had a small increased risk of all-cause and vascular dementia, with larger risks in severe psoriasis and longer time since diagnosis, but absolute risk differences were small. This kind of study cannot show that psoriasis causes dementia and tests no treatment or prevention.

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Study details

Participants360,014
Effect sizeaHR 0.99; aHR 1.10; aHR 1.03
Evidence strengthModerate

How this study scored 50/100

Published in a peer-reviewed journal. Scored zero for study design and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Annals of Clinical and Translational Neurology)
Journal's citation record	1 / 4	Annals of Clinical and Translational Neurology: journal h-index 97 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	4 / 4	360,014 participants
Effect reported	3 / 3	Effect reported with a statistic (interval, p-value, ratio or similar)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 3 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	1.0 citations a year over 3 year(s) since 2025
Impact for its field and year	2 / 6	Cited 1.9× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Charlotte Warren‐Gash: h-index 33 (OpenAlex, whole career)
Institution's track record	2 / 3	University of California, San Francisco: institution h-index 1,915 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 4 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 39743756)
Free to read	2 / 2	Free to read
Total	50 / 100	—

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