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Palladium-platinum bimetallic modified MXene nanozyme for highly sensitive detection of active substances with acetylcholinesterase inhibitory effect
Zhang L, Li A, Shen M, Zhang Z, Wufuer R, Wang D.. Talanta, 2024-10-11
Topic: Brain proteins, microglia and lab models
Alzheimer's disease (AD) is a chronic neurodegenerative disease that threatens to the health of global elderly population. Acetylcholinesterase (AChE) inhibitors are an effective therapeutic agent for AD, and screening of these substances is important for AD treatment. In this work, a Pd-Pt MXene nanoenzyme was successfully synthesized by using the in-situ reduction technique. A colorimetric method for sensitive AChE inhibitor detection was designed based on enzymatic cascade reaction between Pd-Pt MXene and AChE. Briefly, The Pd-Pt MXene material exhibited excellent peroxidase (POD)-like activity due to its bimetallic composition, effectively catalyzing the oxidation of colorless 3,3,5,5-tetramethylbenzidine (TMB) to generate blue oxidized TMB (oxTMB). Under the presence of AChE and acetylthiocholine chloride (ATCh), the POD-like activity of Pd-Pt MXene was significantly inhibited. The activity of this nanoenzyme could be restored after the addition of AChE inhibitors. Using donepezil as an example, colorimetric detection was conducted within a linear range of 0.1 nmol/L to 10 nmol/L and the lowest detection boundary was only 0.35 nmol/L (S/N = 3). Finally, a paper-based platform was designed and constructed, and it has been successfully employed for AChE inhibitor detection in real samples with the aid of a smartphone. In all, this work paves a new way for designing nanoenzyme-based devices towards medicine determination or screening like AChE inhibitor.
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APA 7th
Zhang, L., Li, A., Shen, M., Zhang, Z., Wufuer, R., & Wang, D. (2025). Palladium-platinum bimetallic modified MXene nanozyme for highly sensitive detection of active substances with acetylcholinesterase inhibitory effect. Talanta. https://doi.org/10.1016/j.talanta.2024.127020
Vancouver
Zhang L, Li A, Shen M, Zhang Z, Wufuer R, Wang D. Palladium-platinum bimetallic modified MXene nanozyme for highly sensitive detection of active substances with acetylcholinesterase inhibitory effect. Talanta. 2025. doi:10.1016/j.talanta.2024.127020. PMID: 39406077.
BibTeX
@article{zhang2025-39406077,
author = {Zhang, L. and Li, A. and Shen, M. and Zhang, Z. and Wufuer, R. and Wang, D.},
title = {{Palladium-platinum bimetallic modified MXene nanozyme for highly sensitive detection of active substances with acetylcholinesterase inhibitory effect}},
journal = {Talanta},
year = {2025},
doi = {10.1016/j.talanta.2024.127020},
pmid = {39406077},
url = {https://doi.org/10.1016/j.talanta.2024.127020}
}
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Key findings
- Under the presence of AChE and acetylthiocholine chloride (ATCh), the POD-like activity of Pd-Pt MXene was significantly inhibited.
Study details
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 24 of the 58 points we could judge it on, which is 41 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Talanta) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39406077) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 24 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 24 of the 58 points we could judge it on is 41 out of 100. |
| Total | 41 / 100 | — |
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