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Hydroxytyrosol improves mitochondrial energetics of a cellular model of Alzheimer's disease
Visioli F, Rodríguez-Pérez M, Gómez-Torres Ó, Pintado-Losa C, Burgos-Ramos E.. Nutritional neuroscience, 2020-10-07
Topic: Brain proteins, microglia and lab models
Mitochondrial energetic deficit is one of the hallmarks of neurodegenerative disorders, e.g. Alzheimer´s disease (AD). Adherence to a Mediterranean diet is associated with lower incidence of cognitive decline and AD and extra virgin olive oil's (poly)phenols such as oleuropein and hydroxytyrosol (HT) are being actively studied in this respect. In this study, we assessed the effects of HT on mitochondrial energetic dysfunction in the 7PA2 cells cellular model, i.e. one of the best cellular models of Aβ toxicity with a well-characterized mitochondrial dysfunction typically observed in AD. We report an increase of new mitochondria at 8 h post HT-treatment, which was followed by higher mitochondrial fusion. Further, ATP concentrations were significantly increased after 24 h of treatment with HT as compared with controls. Our data suggest that HT may revert the energetic deficit of a cellular model of AD by potentiating mitochondrial activity. Because HT is being proposed as dietary supplement or component of functional foods, future studies in appropriate animal models and - eventually - humans are warranted to further investigate its potential neuroprotective actions in AD.
Key findings
- Adherence to a Mediterranean diet is associated with lower incidence of cognitive decline and AD and extra virgin olive oil's (poly)phenols such as oleuropein and hydroxytyrosol (HT) are being actively studied in this respect.
- Further, ATP concentrations were significantly increased after 24 h of treatment with HT as compared with controls.
- Our data suggest that HT may revert the energetic deficit of a cellular model of AD by potentiating mitochondrial activity.
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Study details
- Evidence strengthLow
How this study scored 40/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 23 of the 58 points we could judge it on, which is 40 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Nutritional neuroscience) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 33023416) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 23 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 23 of the 58 points we could judge it on is 40 out of 100. |
| Total | 40 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Visioli, F., Rodríguez-Pérez, M., Ó, G.-T., Pintado-Losa, C., & Burgos-Ramos, E. (2022). Hydroxytyrosol improves mitochondrial energetics of a cellular model of Alzheimer's disease. Nutritional neuroscience. https://doi.org/10.1080/1028415x.2020.1829344
Vancouver
Visioli F, Rodríguez-Pérez M, Ó G.-T, Pintado-Losa C, Burgos-Ramos E. Hydroxytyrosol improves mitochondrial energetics of a cellular model of Alzheimer's disease. Nutritional neuroscience. 2022. doi:10.1080/1028415x.2020.1829344. PMID: 33023416.
BibTeX
@article{visioli2022-33023416,
author = {Visioli, F. and Rodríguez-Pérez, M. and Ó, Gómez-Torres and Pintado-Losa, C. and Burgos-Ramos, E.},
title = {{Hydroxytyrosol improves mitochondrial energetics of a cellular model of Alzheimer's disease}},
journal = {Nutritional neuroscience},
year = {2022},
doi = {10.1080/1028415x.2020.1829344},
pmid = {33023416},
url = {https://doi.org/10.1080/1028415x.2020.1829344}
}
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