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Evaluating potential of curcumin loaded solid lipid nanoparticles in aluminium induced behavioural, biochemical and histopathological alterations in mice brain
Kakkar V, Kaur IP.. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2011-08-25
Topic: Brain proteins, microglia and lab models
Aluminium, a well established neurotoxicant, is reported to be involved in the aetiology of Alzheimer's disease (AD) due to its easy admittance and accumulation in central nervous system (CNS). Simultaneous curcumin treatment during the induction of neurotoxicity by AlCl(3) is reported to provide protection. However, the therapeutic potential of curcumin in terms of reversing the neuronal damage once induced is limited due to its compromised bioavailability (BA). We prepared solid lipid nanoparticles of curcumin (C-SLNs) with enhanced BA (32-155 times) and investigated its therapeutic role in alleviating behavioural, biochemical and histochemical changes upon oral administration (100mg/kg) of AlCl(3) in male Lacca mice. Adverse effects of AlCl(3) were completely reversed by oral administration of C-SLNs. Treatment with free curcumin showed ≤ 15% recovery in membrane lipids (LPO) and 22% recovery in acetylcholinesterase (AChE) with respect to AlCl(3) treated group. C-SLNs showed significantly better results (97.46% and 73% recovery in LPO and AChE) at a dose of 50mg/kg, and the results were comparable (p ≤ 0.001) to those achieved with rivastigmine. Histopathology of the brain sections of C-SLNs treated groups also indicated significant improvement. Study highlights the potential of C-SLNs for treatment of AD.
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APA 7th
Kakkar, V., & Kaur, I. P. (2011). Evaluating potential of curcumin loaded solid lipid nanoparticles in aluminium induced behavioural, biochemical and histopathological alterations in mice brain. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. https://doi.org/10.1016/j.fct.2011.08.006
Vancouver
Kakkar V, Kaur IP. Evaluating potential of curcumin loaded solid lipid nanoparticles in aluminium induced behavioural, biochemical and histopathological alterations in mice brain. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2011. doi:10.1016/j.fct.2011.08.006. PMID: 21889563.
BibTeX
@article{kakkar2011-21889563,
author = {Kakkar, V. and Kaur, I. P.},
title = {{Evaluating potential of curcumin loaded solid lipid nanoparticles in aluminium induced behavioural, biochemical and histopathological alterations in mice brain}},
journal = {Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
year = {2011},
doi = {10.1016/j.fct.2011.08.006},
pmid = {21889563},
url = {https://doi.org/10.1016/j.fct.2011.08.006}
}
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Key findings
- C-SLNs showed significantly better results (97.46% and 73% recovery in LPO and AChE) at a dose of 50mg/kg, and the results were comparable (p ≤ 0.001) to those achieved with rivastigmine.
- Histopathology of the brain sections of C-SLNs treated groups also indicated significant improvement.
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Study details
- Effect size97.46%
- Evidence strengthLow
How this study scored 40/100
Published in a peer-reviewed journal. Scored zero for study design, sample size and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multicenter collaboration, so those were left out: it earned 23 of the 58 points we could judge it on, which is 40 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2011 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 2 / 3 | Effect reported as a number, without an interval or test |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “mice”) — scores zero |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 21889563) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 23 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 23 of the 58 points we could judge it on is 40 out of 100. |
| Total | 40 / 100 | — |
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