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47/100

✓ Peer-reviewed alzhub usefulness score 47 out of 100. TREM2 and immune genetics

Topic: Brain proteins, microglia and lab models

In the central nervous system (CNS), microglia are innate immune mononuclear phagocytes (CNS MPs) that can phagocytose infectious particles, apoptotic cells, neurons, and pathological protein aggregates, such as Aβ in Alzheimer's disease (AD). While CD11b + CD45 low microglia account for the majority of CNS MPs, a small population of CD11b + CD45 high CNS MPs is also recognized in AD that surround Aβ plaques. These transcriptionally and pathologically unique CD45 high cells have unclear origin and undefined phagocytic characteristics.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Rangaraju, S., Raza, S. A., Li, N. X., Betarbet, R., Dammer, E. B., Duong, D., et al. (2018). Differential Phagocytic Properties of CD45low Microglia and CD45high Brain Mononuclear Phagocytes-Activation and Age-Related Effects. Frontiers in immunology. https://doi.org/10.3389/fimmu.2018.00405

Vancouver

Rangaraju S, Raza SA, Li NX, Betarbet R, Dammer EB, Duong D, et al. Differential Phagocytic Properties of CD45low Microglia and CD45high Brain Mononuclear Phagocytes-Activation and Age-Related Effects. Frontiers in immunology. 2018. doi:10.3389/fimmu.2018.00405. PMID: 29552013.

BibTeX

@article{rangaraju2018-29552013,
  author  = {Rangaraju, S. and Raza, S. A. and Li, N. X. and Betarbet, R. and Dammer, E. B. and Duong, D. and Lah, J. J. and Seyfried, N. T. and others},
  title   = {{Differential Phagocytic Properties of CD45low Microglia and CD45high Brain Mononuclear Phagocytes-Activation and Age-Related Effects}},
  journal = {Frontiers in immunology},
  year    = {2018},
  doi     = {10.3389/fimmu.2018.00405},
  pmid    = {29552013},
  url     = {https://doi.org/10.3389/fimmu.2018.00405}
}

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Key findings

While CD11b + CD45 low microglia account for the majority of CNS MPs, a small population of CD11b + CD45 high CNS MPs is also recognized in AD that surround Aβ plaques.
These transcriptionally and pathologically unique CD45 high cells have unclear origin and undefined phagocytic characteristics.
We have comprehensively validated rapid flow cytometric assays of bulk-phase and amyloid β fibril (fAβ) phagocytosis and applied these to study acutely isolated CNS MPs.
Using these methods, we provide novel insights into differential abilities of CD11b + CD45 low and CD45 high CNS MPs to phagocytose macroparticles and fAβ under normal, acute, and chronic neuroinflammatory states.

Why it matters

This work developed and validated flow cytometry assays to compare phagocytosis in two types of brain immune cells, including uptake of amyloid-beta fibrils. It is a methods and cell-characterization study and does not test any treatment, cure, or prevention for Alzheimer's disease.

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Study details

Evidence strengthLow

How this study scored 47/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Frontiers in immunology)
Journal's citation record	3 / 4	Frontiers in Immunology: journal h-index 352 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2018 — within 10 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 127 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	12.7 citations a year over 10 year(s) since 2018
Impact for its field and year	3 / 6	Cited 4.0× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 4 other studies in this library
Still being cited	2 / 4	Cited 29 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Allan I. Levey: h-index 161 (OpenAlex, whole career)
Institution's track record	1 / 3	Emory University: institution h-index 1,360 (OpenAlex)
Multi-centre collaboration	0 / 3	OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete)
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 29552013)
Free to read	2 / 2	Free to read
Total	47 / 100	—

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