DEMNET: A Deep Learning Model for Early Diagnosis of Alzheimer Diseases and Dementia From MR Images

Topic: Brain imaging, connectivity and assessment

Alzheimer's Disease (AD) is the most common cause of dementia globally. It steadily worsens from mild to severe, impairing one's ability to complete any work without assistance. It begins to outstrip due to the population ages and diagnosis timeline. For classifying cases, existing approaches incorporate medical history, neuropsychological testing, and Magnetic Resonance Imaging (MRI), but efficient procedures remain inconsistent due to lack of sensitivity and precision. The Convolutional Neural Network (CNN) is utilized to create a framework that can be used to detect specific Alzheimer's disease characteristics from MRI images. By considering four stages of dementia and conducting a particular diagnosis, the proposed model generates high-resolution disease probability maps from the local brain structure to a multilayer perceptron and provides accurate, intuitive visualizations of individual Alzheimer's disease risk. To avoid the problem of class imbalance, the samples should be evenly distributed among the classes. The obtained MRI image dataset from Kaggle has a major class imbalance problem. A DEMentia NETwork (DEMNET) is proposed to detect the dementia stages from MRI. The DEMNET achieves an accuracy of 95.23%, Area Under Curve (AUC) of 97% and Cohen's Kappa value of 0.93 from the Kaggle dataset, which is superior to existing methods. We also used the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset to predict AD classes in order to assess the efficacy of the proposed model.

Key findings

• To avoid the problem of class imbalance, the samples should be evenly distributed among the classes.
• The obtained MRI image dataset from Kaggle has a major class imbalance problem.
• A DEMentia NETwork (DEMNET) is proposed to detect the dementia stages from MRI.
• The DEMNET achieves an accuracy of 95.23%, Area Under Curve (AUC) of 97% and Cohen's Kappa value of 0.93 from the Kaggle dataset, which is superior to existing methods.
• We also used the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset to predict AD classes in order to assess the efficacy of the proposed model.

Study details

• Effect size95.23%
• Evidence strengthLow

Read the original

• DOI: 10.1109/access.2021.3090474
• Original source →

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@article{murugan2021-896004c6,
  author  = {Murugan, Suriya and Venkatesan, Chandran and Sumithra, M. G. and Gao, Xiao‐Zhi and Elakkiya, B. and Akila, Muthuramalingam and Manoharan, S.},
  title   = {{DEMNET: A Deep Learning Model for Early Diagnosis of Alzheimer Diseases and Dementia From MR Images}},
  journal = {IEEE Access},
  year    = {2021},
  doi     = {10.1109/access.2021.3090474},
  url     = {https://doi.org/10.1109/access.2021.3090474}
}

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