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Characterization of tau protein present in microtubules and paired helical filaments of Alzheimer's disease patient's brain
Nieto A, Montejo de Garcini E, Correas I, Avila J.. Neuroscience, 1990-01-01
Topic: Amyloid, tau and blood-test diagnosis
Plain-language summary
Two proteins immunologically related to porcine tau protein are found in the brain of Alzheimer's disease patients. One is bound to microtubules and, after isolation by co-polymerization with tubulin, shows a size and tryptic peptide map, similar to the microtubule-associated tau protein, present in the brain of non-demented patients. The other tau-related protein is present as the major protein of a purified fraction of paired helical filaments. The paired helical filament-associated protein shows smaller molecular weight (33,000) than microtubule-associated tau; however, this 33,000 mol. wt protein reacts with a monospecific anti-tau antibody and with an antibody to a 19-amino acid peptide corresponding to amino acids 228-246 of human tau. Furthermore, the 33,000 mol. wt protein and the tau protein have similar tryptic peptide maps. These results suggest that the paired helical filament protein is a modified form of the microtubule-associated tau protein.
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APA 7th
Nieto, A., Montejo de Garcini, E., Correas, I., & Avila, J. (1990). Characterization of tau protein present in microtubules and paired helical filaments of Alzheimer's disease patient's brain. Neuroscience. https://doi.org/10.1016/0306-4522(90)90201-e
Vancouver
Nieto A, Montejo de Garcini E, Correas I, Avila J. Characterization of tau protein present in microtubules and paired helical filaments of Alzheimer's disease patient's brain. Neuroscience. 1990. doi:10.1016/0306-4522(90)90201-e. PMID: 2123019.
BibTeX
@article{nieto1990-2123019,
author = {Nieto, A. and Montejo de Garcini, E. and Correas, I. and Avila, J.},
title = {{Characterization of tau protein present in microtubules and paired helical filaments of Alzheimer's disease patient's brain}},
journal = {Neuroscience},
year = {1990},
doi = {10.1016/0306-4522(90)90201-e},
pmid = {2123019},
url = {https://doi.org/10.1016/0306-4522(90)90201-e}
}
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Key findings
- These results suggest that the paired helical filament protein is a modified form of the microtubule-associated tau protein.
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Study details
- Evidence strengthLow
How this study scored 36/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multicenter collaboration, so those were left out: it earned 21 of the 58 points we could judge it on, which is 36 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neuroscience) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1990 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 2123019) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 21 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 21 of the 58 points we could judge it on is 36 out of 100. |
| Total | 36 / 100 | — |
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Also tagged “paired-helical”
3 studies in the library carry the topic tag “paired-helical”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 3 tagged studies.