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Automated cortical thickness measurements from MRI can accurately separate Alzheimer's patients from normal elderly controls
Lerch JP, Pruessner J, Zijdenbos AP, Collins DL, Teipel SJ, Hampel H, Evans AC.. Neurobiology of aging, 2006-11-13
Topic: Amyloid, tau and blood-test diagnosis
We investigated the potential of fully automated measurements of cortical thickness to reproduce the clinical diagnosis in Alzheimer's Disease (AD) using 19 patients and 17 healthy controls. Thickness maps were analyzed using three different discriminant techniques to separate patients from controls. All analyses were performed using leave-one-out cross-validation to avoid overtraining of the discriminants. The results show regionally variant patterns of discrimination ability, with over 90% accuracy obtained in the medial temporal lobes and other limbic structures. Multivariate discriminant analysis produced 100% accuracy with six different combinations, all involving the parahippocampal gyrus. We therefore propose automated measurements of cortical thickness as a tool to improve the clinical diagnosis of probable AD, as well as a research method to gain unique insight into the etiology of cortical pathology in the disease.
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APA 7th
Lerch, J. P., Pruessner, J., Zijdenbos, A. P., Collins, D. L., Teipel, S. J., Hampel, H., et al. (2008). Automated cortical thickness measurements from MRI can accurately separate Alzheimer's patients from normal elderly controls. Neurobiology of aging. https://doi.org/10.1016/j.neurobiolaging.2006.09.013
Vancouver
Lerch JP, Pruessner J, Zijdenbos AP, Collins DL, Teipel SJ, Hampel H, et al. Automated cortical thickness measurements from MRI can accurately separate Alzheimer's patients from normal elderly controls. Neurobiology of aging. 2008. doi:10.1016/j.neurobiolaging.2006.09.013. PMID: 17097767.
BibTeX
@article{lerch2008-17097767,
author = {Lerch, J. P. and Pruessner, J. and Zijdenbos, A. P. and Collins, D. L. and Teipel, S. J. and Hampel, H. and Evans, A. C.},
title = {{Automated cortical thickness measurements from MRI can accurately separate Alzheimer's patients from normal elderly controls}},
journal = {Neurobiology of aging},
year = {2008},
doi = {10.1016/j.neurobiolaging.2006.09.013},
pmid = {17097767},
url = {https://doi.org/10.1016/j.neurobiolaging.2006.09.013}
}
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Key findings
- The results show regionally variant patterns of discrimination ability, with over 90% accuracy obtained in the medial temporal lobes and other limbic structures.
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Study details
- Participants19
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 25 of the 58 points we could judge it on, which is 43 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neurobiology of aging) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2008 — within 20 year(s) of the newest study here |
| Sample size | 1 / 4 | 19 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 17097767) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 25 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 25 of the 58 points we could judge it on is 43 out of 100. |
| Total | 43 / 100 | — |
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