Auditory Verbal Learning Test is Superior to Rey-Osterrieth Complex Figure Memory for Predicting Mild Cognitive Impairment to Alzheimer's Disease

Topic: Amyloid, tau and blood-test diagnosis

Objective To carry out meaningful comparisons on results of different research studies on mild cognitive impairment (MCI), it is critical to select an appropriate objective memory test to examine memory deficit. We aim to refine the operational criteria of amnestic MCI (aMCI) on neuropsychological tests that optimally balance the sensitivity and specificity. Methods We focused on 206 non-demented subjects from memory clinic. We then classified each individual as having MCI or subjective cognitive decline (SCD) according to different neuropsychological criteria. By following them longitudinally, clinical outcomes were compared to evaluate the stability of MCI diagnoses and prediction of progression. Results The delayed recall of auditory verbal learning test (AVLT_DR) identified 116 subjects as MCI, resulted in the conversion rate as 44% over the roughly 30-month time interval, missed 7.8% incipient Alzheimer's disease (AD) patients in SCD group who eventually converted to dementia. The delayed recall of complex figure test (CFT_DR) identified fewer MCI patients (n=95) and misdiagnosed more preclinical AD patients (15.3%), in comparison with AVLT criterion. Criterion requiring deficits in both tests produced higher conversion rate (54.3%), but resulted in higher misdiagnosis rate (14.7%) simultaneously. The AVLT criterion had the largest area under the curve (0.7248, p Conclusion AVLT is superior to CFT in the stability of diagnoses and prediction of progression. In the clinical setting, the "one test" criterion AVLT has similar sensitivity to both-deficits methods, and is optimal in balancing sensitivity and specificity.

Key findings

• Objective To carry out meaningful comparisons on results of different research studies on mild cognitive impairment (MCI), it is critical to select an appropriate objective memory test to examine memory deficit.
• By following them longitudinally, clinical outcomes were compared to evaluate the stability of MCI diagnoses and prediction of progression.
• Results The delayed recall of auditory verbal learning test (AVLT_DR) identified 116 subjects as MCI, resulted in the conversion rate as 44% over the roughly 30-month time interval, missed 7.8% incipient Alzheimer's disease (AD) patients in SCD group who eventually converted to dementia.

Why it matters

In 206 non-demented people from a memory clinic, using delayed recall of the auditory verbal learning test to define mild cognitive impairment gave a 44% conversion rate over about 30 months and missed fewer incipient Alzheimer's cases than a figure memory test. The study is about which memory test best predicts progression, not about treating or preventing the disease.

Study details

• Participants95
• Effect size7.8%; 15.3%; 54.3%
• Evidence strengthLow

Read the original

• DOI: 10.2174/1567205012666150530202729
• PubMed: 26027810
• Original source →

May need a subscription OpenAlex found no free copy of the full text (checked 6 Feb 1020), so the publisher may charge for it. The PubMed abstract is free.

@article{zhao2015-26027810,
  author  = {Zhao, Q. and Guo, Q. and Liang, X. and Chen, M. and Zhou, Y. and Ding, D. and Hong, Z.},
  title   = {{Auditory Verbal Learning Test is Superior to Rey-Osterrieth Complex Figure Memory for Predicting Mild Cognitive Impairment to Alzheimer's Disease}},
  journal = {Current Alzheimer research},
  year    = {2015},
  doi     = {10.2174/1567205012666150530202729},
  pmid    = {26027810},
  url     = {https://doi.org/10.2174/1567205012666150530202729}
}

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