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Association Between Dementia and Optical Coherence Tomography Scan Quality
Reuben Jyong Kiat Foo, Damon Wing Kee Wong, Nur Fidyana Binte Abdul Gani, Bingyao Tan, Munirah Binte Ismail, Gerhard Garhöfer, Laetitia Hinterhuber, Narayanaswamy Venketasubramanian et al.. Aging and Disease, 2025-01-01
Topic: Risk, prevention and care in population studies
It is generally assumed that dementia affects the quality of optical coherence tomography (OCT) scans. However, the magnitude of this effect and its independence from other factors require further clarification. In this cross-sectional study, our aim was to evaluate the association between cognitive impairment and OCT scan quality, adjusting for key confounders, in a multiethnic cohort. 541 participants aged 50 years or older were recruited from memory clinics and the community at the National University Hospital and St. Luke's Hospital, Singapore. They were then stratified into three groups: no cognitive impairment (NCI, n=112), cognitive impairment without dementia (CIND, n=235), and dementia (n=194); OCT scan quality was subsequently assessed based on the presence and severity of artifacts. We found that dementia patients were nearly three times more likely to produce poor-quality OCT scans compared to NCI participants (adjusted odds ratio [OR]=2.90; 95% CI, 1.24-6.80). Lower cognitive scores, including Mini-Mental State Examination (MMSE) (OR=0.92; 95% CI, 0.88-0.96), Montreal Cognitive Assessment (MoCA) (OR=0.90; 95% CI, 0.86-0.94), and higher Clinical Dementia Rating (CDR) scores (OR=2.11; 95% CI, 1.43-3.10), were also independently associated with poor scan quality. In conclusion, cognitive impairment, particularly dementia, substantially increases the likelihood of poor-quality OCT scans, even after accounting for key demographic and clinical factors. Hence, strategies tailored to improve imaging in this population are essential for enhancing diagnostic accuracy and patient care.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Foo, R. J. K., Wong, D. W. K., Gani, N. F. B. A., Tan, B., Ismail, M. B., Garhöfer, G., et al. (2025). Association Between Dementia and Optical Coherence Tomography Scan Quality. Aging and Disease. https://doi.org/10.14336/ad.2024.1744
Vancouver
Foo RJK, Wong DWK, Gani NFBA, Tan B, Ismail MB, Garhöfer G, et al. Association Between Dementia and Optical Coherence Tomography Scan Quality. Aging and Disease. 2025. doi:10.14336/ad.2024.1744. PMID: 40153581.
BibTeX
@article{foo2025-40153581,
author = {Foo, Reuben Jyong Kiat and Wong, Damon Wing Kee and Gani, Nur Fidyana Binte Abdul and Tan, Bingyao and Ismail, Munirah Binte and Garhöfer, Gerhard and Hinterhuber, Laetitia and Venketasubramanian, Narayanaswamy and others},
title = {{Association Between Dementia and Optical Coherence Tomography Scan Quality}},
journal = {Aging and Disease},
year = {2025},
doi = {10.14336/ad.2024.1744},
pmid = {40153581},
url = {https://doi.org/10.14336/ad.2024.1744}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- We found that dementia patients were nearly three times more likely to produce poor-quality OCT scans compared to NCI participants (adjusted odds ratio [OR]=2.90; 95% CI, 1.24-6.80).
- Lower cognitive scores, including Mini-Mental State Examination (MMSE) (OR=0.92; 95% CI, 0.88-0.96), Montreal Cognitive Assessment (MoCA) (OR=0.90; 95% CI, 0.86-0.94), and higher Clinical Dementia Rating (CDR) scores (OR=2.11; 95% CI, 1.43-3.10), were also independently associated with poor scan quality.
- In conclusion, cognitive impairment, particularly dementia, substantially increases the likelihood of poor-quality OCT scans, even after accounting for key demographic and clinical factors.
Why it matters
In this cross-sectional study, dementia patients were nearly three times more likely to produce poor-quality OCT scans than participants with no cognitive impairment. This is about scan quality in people with cognitive impairment and does not address treating, curing or preventing Alzheimer's disease.
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Study details
- Study designcross-sectional
- Participants112
- Effect sizeOR=0.92; OR=0.90; OR=2.11
- Evidence strengthModerate
How this study scored 51/100
Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Aging and Disease) |
| Journal's citation record | 1 / 4 | Aging and Disease: journal h-index 107 (OpenAlex, 2026-10-29) |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 2 / 4 | 112 participants |
| Effect reported | 3 / 3 | Effect reported with a statistic (interval, p-value, ratio or similar) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 3 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 1.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 1 / 4 | Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Jacqueline Chua: h-index 37 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | National University of Singapore: institution h-index 1,166 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 8 institution(s) in 4 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40153581) |
| Free to read | 2 / 2 | Free to read |
| Total | 51 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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