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An Enteric Bacterial Infection Triggers Neuroinflammation and Neurobehavioral Impairment in 3xTg-AD Transgenic Mice
Park G, Kadyan S, Hochuli N, Salazar G, Laitano O, Chakrabarty P, Efron PA, Zafar MA et al.. The Journal of infectious diseases, 2024-09-01
Topic: Brain proteins, microglia and lab models
Background Klebsiella pneumoniae is infamous for hospital-acquired infections and sepsis, which have also been linked to Alzheimer disease (AD)-related neuroinflammatory and neurodegenerative impairment. However, its causative and mechanistic role in AD pathology remains unstudied. Methods A preclinical model of K. pneumoniae enteric infection and colonization is developed in an AD model (3xTg-AD mice) to investigate whether and how K. pneumoniae pathogenesis exacerbates neuropathogenesis via the gut-blood-brain axis.
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APA 7th
Park, G., Kadyan, S., Hochuli, N., Salazar, G., Laitano, O., Chakrabarty, P., et al. (2024). An Enteric Bacterial Infection Triggers Neuroinflammation and Neurobehavioral Impairment in 3xTg-AD Transgenic Mice. The Journal of infectious diseases. https://doi.org/10.1093/infdis/jiae165
Vancouver
Park G, Kadyan S, Hochuli N, Salazar G, Laitano O, Chakrabarty P, et al. An Enteric Bacterial Infection Triggers Neuroinflammation and Neurobehavioral Impairment in 3xTg-AD Transgenic Mice. The Journal of infectious diseases. 2024. doi:10.1093/infdis/jiae165. PMID: 39255397.
BibTeX
@article{park2024-39255397,
author = {Park, G. and Kadyan, S. and Hochuli, N. and Salazar, G. and Laitano, O. and Chakrabarty, P. and Efron, P. A. and Zafar, M. A. and others},
title = {{An Enteric Bacterial Infection Triggers Neuroinflammation and Neurobehavioral Impairment in 3xTg-AD Transgenic Mice}},
journal = {The Journal of infectious diseases},
year = {2024},
doi = {10.1093/infdis/jiae165},
pmid = {39255397},
url = {https://doi.org/10.1093/infdis/jiae165}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- However, its causative and mechanistic role in AD pathology remains unstudied.
- Methods A preclinical model of K. pneumoniae enteric infection and colonization is developed in an AD model (3xTg-AD mice) to investigate whether and how K. pneumoniae pathogenesis exacerbates neuropathogenesis via the gut-blood-brain axis.
- Results K. pneumoniae, particularly under antibiotic-induced dysbiosis, was able to translocate from the gut to the bloodstream by penetrating the gut epithelial barrier.
- Subsequently, K. pneumoniae infiltrated the brain by breaching the blood-brain barrier.
Why it matters
In this mouse model, Klebsiella pneumoniae gut infection, especially after antibiotic-induced disruption of gut bacteria, moved from the gut into the bloodstream and worsened brain inflammation and behavior in Alzheimer-model mice. This is early animal work, so it does not yet show that such infections affect Alzheimer's disease in people or that treating them would help.
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Study details
- Evidence strengthLow
How this study scored 43/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The Journal of infectious diseases) |
| Journal's citation record | 3 / 4 | The Journal of Infectious Diseases: journal h-index 370 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2024 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “3xtg”) — scores zero |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 3 / 7 | Cited 22 times (OpenAlex, 2026-10-10) |
| Citations per year | 2 / 5 | 5.5 citations a year over 4 year(s) since 2024 |
| Impact for its field and year | 3 / 6 | Cited 5.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 2 / 4 | Cited 22 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Ravinder Nagpal: h-index 54 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Florida: institution h-index 1,303 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 5 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 39255397) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 43 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1093/infdis/jiae165
- PubMed: 39255397
- Original source →
- Free full text: The Journal of Infectious Diseases →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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