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A Paper Strip-Based Photoinduced Electrogenerated Chemiluminescence Platform with CTF/PMo12 Heterojunction-Sensitive Glutamic Acid Detection
Sedghi Mehrbani R, Mohhamadian M, Dashtian K, Naseri N, Zare-Dorabei R, Noroozifar M, Kerman K, Mahdavi M.. Analytical chemistry, 2025-05-29
Topic: Brain proteins, microglia and lab models
Glutamic acid (GA), a crucial neurotransmitter, plays a significant role in brain function, muscle health, and various neurological disorders. Elevated GA levels have been associated with conditions such as stroke, Parkinson's disease, epilepsy, and Alzheimer's disease. Accurate detection of GA levels is paramount for both diagnostic and research purposes. Herein, we develop a photoinduced electrogenerated chemiluminescence (PECL) test strip fiber paper coated with a covalent triazine framework (CTF)/H 3 PMo 12 O 40 polyoxometalate (PMo12) heterojunction. Under blue-light irradiation, photogenerated carriers were separated by an electric field, π-electron delocalization, and polarization, leaving holes on the surface of PMo12 to drive ECL reactions based on luminol oxidation, enabling the detection of GA. This detection resulted in a PECL signal, and fluorometry information, including RGB values, was captured by using a smartphone. The PECL platform enabled the sensitive detection of GA as a neurotransmitter within a linear range of 0.05-1.7 mM, with a low limit of detection (LOD) of 15 nM. The results validated the safety and feasibility of this approach to detect GA in biological samples with satisfactory selectivity against other molecules. The combination of PECL with a smartphone reader presents an exciting avenue for the development of test strips on-site for visual real-time monitoring. This integration offers a high-throughput approach suitable for applications in point-of-care testing and disease monitoring.
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APA 7th
Sedghi Mehrbani, R., Mohhamadian, M., Dashtian, K., Naseri, N., Zare-Dorabei, R., Noroozifar, M., et al. (2025). A Paper Strip-Based Photoinduced Electrogenerated Chemiluminescence Platform with CTF/PMo12 Heterojunction-Sensitive Glutamic Acid Detection. Analytical chemistry. https://doi.org/10.1021/acs.analchem.4c06603
Vancouver
Sedghi Mehrbani R, Mohhamadian M, Dashtian K, Naseri N, Zare-Dorabei R, Noroozifar M, et al. A Paper Strip-Based Photoinduced Electrogenerated Chemiluminescence Platform with CTF/PMo12 Heterojunction-Sensitive Glutamic Acid Detection. Analytical chemistry. 2025. doi:10.1021/acs.analchem.4c06603. PMID: 40440107.
BibTeX
@article{sedghimehrbani2025-40440107,
author = {Sedghi Mehrbani, R. and Mohhamadian, M. and Dashtian, K. and Naseri, N. and Zare-Dorabei, R. and Noroozifar, M. and Kerman, K. and Mahdavi, M.},
title = {{A Paper Strip-Based Photoinduced Electrogenerated Chemiluminescence Platform with CTF/PMo12 Heterojunction-Sensitive Glutamic Acid Detection}},
journal = {Analytical chemistry},
year = {2025},
doi = {10.1021/acs.analchem.4c06603},
pmid = {40440107},
url = {https://doi.org/10.1021/acs.analchem.4c06603}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
Key findings
- Glutamic acid (GA), a crucial neurotransmitter, plays a significant role in brain function, muscle health, and various neurological disorders.
- Elevated GA levels have been associated with conditions such as stroke, Parkinson's disease, epilepsy, and Alzheimer's disease.
- The results validated the safety and feasibility of this approach to detect GA in biological samples with satisfactory selectivity against other molecules.
Study details
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 24 of the 58 points we could judge it on, which is 41 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Analytical chemistry) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 40440107) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 24 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 24 of the 58 points we could judge it on is 41 out of 100. |
| Total | 41 / 100 | — |
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