27,380 Alzheimer's and dementia studies in plain English, each scored out of 100.
MedCAT Comorbidity demonstrated predictive ability for mortality (HR 1.11 per condition), although the model fit was better using comorbidity from hospital admission data. 4 key findings →
Participants: 3,543 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Vascular dementia (VaD) is a prevalent and devastating neurocognitive disorder characterized by profound white matter damage, yet the precise cellular mechanisms linking cerebrovascular stress to demyelination remain poorly understood. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Absolute BPV was associated with mortality, and DBP and MAP variability with overall stroke, after accounting for glycemic status and mean blood pressure. 5 key findings →
Design: prospective cohort Participants: 57,611 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Seasonally normalized 25(OH)D identifies a reproducible state of systemic vulnerability while reducing exposure misclassification caused by calendar timing of measurement. 5 key findings →
Design: longitudinal study Participants: 412,020 Evidence: moderate
Full summary, score breakdown and related studies → Original source
The two sites associated with interactions between AD and a metabolic condition could explain the influence that those conditions have on the risk for AD and are prime candidates for future study. 3 key findings →
Participants: 551 Evidence: moderate
Full summary, score breakdown and related studies → Original source
The glycolytic regulator PFKFB3 supports dysfunctional β-cell states, but its role in pancreatic Ca 2+ signaling remains unclear. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Postmitotic neurons must preserve genome integrity for decades despite continuous oxidative, transcription-associated, and environmental DNA damage. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Amyloid β-protein (Aβ), which is known for its role in Alzheimer's disease (AD), is also involved in several physiological functions. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Vascular dementia (VaD) is a leading cause of cognitive decline with no disease-modifying therapies. 2 key findings →
Participants: 437,749 Evidence: low
Full summary, score breakdown and related studies → Original source
In brain, inverse-variance random-effects meta-analysis (DerSimonian–Laird) across six independent postmortem adult-brain GEO cohorts (GSE33000, GSE132903, GSE173955, GSE159699, GSE5281, GSE48350) yielded 458 analyzable panel genes, 167 at Benjamini–Hochberg FDR < 0.05, and 141 high-confidence genes (FDR < 0.05, measured in at least three cohorts, direction-concordant in at least 70% of cohorts, and nominally significant in at least two cohorts). 1 key finding →
Design: meta-analysis Participants: 329 Evidence: high
Full summary, score breakdown and related studies → Original source
Hypertension is associated with lower risk of dementia-related outcomes in aECAD patients. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
CAD was not associated with global or domain-level neurocognitive performance. 5 key findings →
Design: cohort study Participants: 512 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Higher educational attainment is associated with steeper measured cognitive decline among older adults in India, but whether this association is uniform across the country is unknown. 2 key findings →
Design: longitudinal study Participants: 2,510 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Dementia is a progressive syndrome characterized by neurodegeneration across distributed brain networks that results in cognitive, behavioral, and functional declines. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
The questionnaire demonstrated promising preliminary structure and internal consistency. 5 key findings →
Design: cross-sectional Evidence: low
Full summary, score breakdown and related studies → Original source
Cognitive staging and everyday function are not interchangeable. 1 key finding →
Design: retrospective cohort Participants: 202,508 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Dementia prevention education increasingly seeks to translate evidence about modifiable risk factors into meaningful public engagement and preventive action. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Participants perceived that interpreter involvement could support communication, direct participation, and the interpretability of assessments when it was timely, appropriately prepared, and aligned with clinical roles. 1 key finding →
Design: cross-sectional Participants: 64 Evidence: low
Full summary, score breakdown and related studies → Original source
The increasing prevalence of neurodegenerative diseases (NDs), especially Alzheimer's and Parkinson's, is a major public health concern in the Gulf countries (GCs) due to the rapid increase in life expectancy and population aging. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
These findings indicate that cognitive impairment may mark a population vulnerable to medication complexity rather than independently driving DDI risk, with polypharmacy emerging as the principal modifiable determinant. 4 key findings →
Participants: 101 Evidence: low
Full summary, score breakdown and related studies → Original source
Dementia dyads experience substantial informational, emotional, and practical support needs in the early stages of MCI and AD/ADRD. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Prior work has demonstrated a link between cognitive impairment and financial vulnerability. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Mean scores were 23.45/30 (78.2%) for general Alzheimer’s disease knowledge and 13.75/18 (76.4%) for BPSD knowledge; the scores were moderately correlated (ρ = .598, p < .001). 3 key findings →
Design: cross-sectional Participants: 196 Evidence: low
Full summary, score breakdown and related studies → Original source
Mean age was 59.6 years, and 57.8% were male. 4 key findings →
Design: cross-sectional Evidence: low
Full summary, score breakdown and related studies → Original source
In this bvFTD cohort, structural volumes of key frontotemporal and perisylvian regions did not predict behavioral or language impairments after correction for multiple comparisons. 3 key findings →
Design: longitudinal study Participants: 87 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 27,380 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,380 records, built mostly from automated pulls of Europe PMC (60.6% of the library) and OpenAlex (18.6%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,032 records (3.8% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →