27,380 Alzheimer's and dementia studies in plain English, each scored out of 100.
The social, structural, and physical conditions in which individuals live, work, and age, collectively termed social determinants of health (SDOH), are associated with risk of Alzheimer's disease and related dementias (ADRD). 2 key findings →
Design: cross-sectional Evidence: low
Full summary, score breakdown and related studies → Original source
Alzheimer’s Disease (AD) changes how the brain’s electrical activity behaves, and these changes can, in principle, be picked up directly from a resting-state EEG recording without any invasive testing. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Neuropsychiatric symptoms (NPS) are highly prevalent in Mild Cognitive Impairment (MCI), conceptualized as an intermediate clinical state between normal aging and dementia. 4 key findings →
Design: longitudinal study Evidence: moderate
Full summary, score breakdown and related studies → Original source
Dynamic functional network connectivity (dFNC) commonly identifies recurring connectivity states from resting-state fMRI, but states derived independently in each dataset lack guaranteed correspondence across studies and cannot be directly estimated in new participants. 5 key findings →
Design: post-hoc analysis Evidence: moderate
Full summary, score breakdown and related studies → Original source
This study investigated volumetric MRI differences of the thalamic nuclei in asymptomatic young adult C9orf72 expansion carriers compared to non-carriers, and examined spatial associations with normative thalamic transcriptomics from 8 weeks post-conception through middle age. 3 key findings →
Participants: 72 Evidence: low
Full summary, score breakdown and related studies → Original source
For more than 150 years, since the idea that mental illness is rooted in the brain first emerged in the mid-1800s, psychiatry has searched for a reliable biological system to anchor its understanding of mental illness. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Resting-state EEG is a scalable modality for neurophysiological screening, but conventional spectral descriptors capture only part of the signal organization altered in neurodegenerative disease. 1 key finding →
Evidence: high
Full summary, score breakdown and related studies → Original source
The disorders fell into one of three categories based on the topographic relationship of the disease-specific and healthy networks. 5 key findings →
Participants: 1,117 Evidence: low
Full summary, score breakdown and related studies → Original source
Electroencephalography (EEG) records cortical activity with high temporal resolution without radiation and at low cost, which makes it a practical signal for automated screening of neurological disorders. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The choroid plexus (ChP) is a highly vascularized structure located in the brain ventricles that plays important roles in multiple central nervous system functions. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
For more than 150 years, since the idea that mental illness is rooted in the brain first emerged in the mid-1800s, psychiatry has searched for a reliable biological system to anchor its understanding of mental illness. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Constant LL exposure induced complete arrhythmicity and impaired recognition, working, and spatial reference memory. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Lysosomal distribution is critical for numerous biological functions within the cell, including protein degradation in autophagosomes, cholesterol homeostasis, and cell invasion. 5 key findings →
Evidence: moderate
Full summary, score breakdown and related studies → Original source
As the only central nervous system tissue that can be directly imaged non-invasively using widely available technology, the retina offers a uniquely accessible window into the brain. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Sleep disturbances are common early features of neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s disease (PD). 5 key findings →
Design: longitudinal study Evidence: moderate
Full summary, score breakdown and related studies → Original source
Our results converge on the conclusion that vtaVNS does not uniformly amplify cortical responses to external stimuli. 5 key findings →
Participants: 20 Evidence: low
Full summary, score breakdown and related studies → Original source
The basal forebrain is an early site of pathology in Alzheimer’s disease (AD). 3 key findings →
Design: longitudinal study Participants: 116 Evidence: moderate
Full summary, score breakdown and related studies → Original source
We then integrated healthy retinal expression, AD retinal proteomics, and PD aqueous-humor proteomics with the brain-concordance results. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
We built a computer model that reproduces the rhythms and, crucially, lets the measured timing between slow waves and spindles control how strongly memories are written into cortex. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Sleep disturbances are pervasive in Lewy body disorders (LBD), but their neurophysiological basis remains unclear. 1 key finding →
Participants: 109 Evidence: low
Full summary, score breakdown and related studies → Original source
In the primary visual cortex (V1), we show that cortical magnification (M) is a deterministic Riemannian coordinate transformation (M \propto 1/\sqrt{\det g}) that equalizes information pressure between the spherical retina and planar cortex.2. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Chronic metabolic diseases, including Type 2 Diabetes, hypertension, non-alcoholic fatty liver disease (NAFLD), prostate enlargement, musculoskeletal joint friction, cardiac arrhythmias, neurodegenerative waste accumulation (Alzheimer's), and elevated intraocular hydraulic pressure (glaucoma), are frequently treated as distinct, unavoidable consequences of chronological aging. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The short-wavelength content of available light declines steadily through the afternoon, well before nightfall, while the long-wavelength component remains nearly constant. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Circadian disruption, notably sleep disturbances, serves as an early indicator of Alzheimer’s disease (AD), preceding cognitive symptoms like memory loss. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Forty-eight studies, mostly of weak- or moderate-quality, met inclusion criteria. 5 key findings →
Design: systematic review Evidence: high
Full summary, score breakdown and related studies → Original source
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 27,380 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,380 records, built mostly from automated pulls of Europe PMC (60.6% of the library) and OpenAlex (18.6%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,032 records (3.8% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →