In the dentate gyrus of the hippocampus, cell birth and maturation into neurons, or neurogenesis, occur throughout the lifetime of animals and humans. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Research
30,980 Alzheimer's and dementia studies in plain English, each scored out of 100.
36/100
Using quantitative structural MRI protocols, we examined the effects of age on alterations in entorhinal cortex (EC) volume. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The hippocampus (HC) and associated neural structures are hypothesized to contribute to individual differences in human spatial navigation. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Glucocorticoids (GCs) are hormones secreted by the adrenal glands as an endocrine response to stress. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Most previous magnetic resonance imaging (MRI) studies of patients with bipolar disorder (BD) report similar hippocampus (HC) volumes across patients and controls, but because patients studied were heterogeneous with respect to course of illness variables and medication status, the conclusions of these studies remain equivocal. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
A stressful event increases the risk of developing depression later in life, but the possible predisposing factors remain unknown. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
One of the most replicated findings has been that hippocampus volume is decreased in patients with major depressive disorder (MDD). 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
In the study of brain morphometry, it is accepted that a relationship exists between brain structure and function, both normal and abnormal. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Iron has a role in brain injury after IVH. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The concept of amnestic mild cognitive impairment (MCI) describes older people who show a decline predominantly in memory function, but who do not meet criteria for dementia. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
We compared hippocampal volume measures obtained by manual tracing to automatic segmentation with FreeSurfer in 44 younger (20-30 years) and 47 older (60-70 years) adults, each measured with magnetic resonance imaging (MRI) over three successive time points, separated by four months. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
This result replicates previous findings of smaller hippocampal volumes in PTSD patients, but in an underinvestigated population, suggesting that either smaller hippocampal volume is a predisposing factor in the development of PTSD or that damage occurs within months of trauma, rather than a number of years. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Recent epidemiological and experimental studies suggest a link between cognitive decline in late adulthood and sports concussions sustained in early adulthood. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
This study demonstrates that the impact of the BDNF Val66Met polymorphism is not confined to the hippocampus but also extends to the parahippocampal gyrus and the amygdala. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The hippocampus is essential for the formation and retrieval of memories and is a crucial neural structure sub-serving complex cognition. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Reduction of cerebral blood flow is an important risk factor for dementia states and other brain dysfunctions. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Prematurity is associated with mild brain structural differences that persist at 8 years of age, with associated lower scores in neurocognitive assessments. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Lower volume in the right hippocampus in chronic cannabis users was corroborated. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Bipolar disorder (BD) is thought to be associated with abnormalities within discrete brain regions associated with emotional regulation, particularly in fronto-limbic-subcortical circuits. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
These results suggest that alterations in amygdala:hippocampal volume ratios in pediatric MDD may more reflect severity of associated anxiety than depression. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
(18)F-THK523 does not bind to Aβ in vivo, while following the known distribution of paired helical filaments (PHF)-tau in the brain. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Cognitive function and peripheral glucose regulation both decrease with age. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Hypoxia damages multiple organ systems especially those with high oxygen utilization such as the central nervous system. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
36/100
Since hippocampal volume has been found to be an early biomarker for Alzheimer's disease, there is large interest in automated methods to accurately, robustly, and reproducibly extract the hippocampus from MRI data. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
These data support the view that heavy drinking exerts a unique and selectively injurious effect on the hippocampus. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Where “Free full text” comes from
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
How the 0–100 score works — and why some entries are capped
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
- Journal tier up to 10 pts
- Journal's citation record up to 4 pts
- Study design up to 12 pts
- Strength of evidence up to 5 pts
- Peer-review validation up to 10 pts
- How recent up to 5 pts
- Sample size up to 4 pts
- Effect reported up to 3 pts
- Studied in people up to 3 pts
- Randomised / blinded up to 2 pts
- Times cited up to 7 pts
- Citations per year up to 5 pts
- Impact for its field and year up to 6 pts
- Cited by studies here up to 6 pts
- Still being cited up to 4 pts
- Senior author's track record up to 4 pts
- Institution's track record up to 3 pts
- Multi-centre collaboration up to 3 pts
- Indexed in PubMed up to 2 pts
- Free to read up to 2 pts
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 30,980 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
What this library is — and isn't
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 30,980 records, built mostly from automated pulls of Europe PMC (65.2% of the library) and OpenAlex (16.4%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,042 records (3.4% of the library) are not peer-reviewed — 967 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →
Newest studies, as a dated timeline → Atom feed Where this research is being discussed: events