Hypoxia damages multiple organ systems especially those with high oxygen utilization such as the central nervous system. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Research
28,980 Alzheimer's and dementia studies in plain English, each scored out of 100.
36/100
Since hippocampal volume has been found to be an early biomarker for Alzheimer's disease, there is large interest in automated methods to accurately, robustly, and reproducibly extract the hippocampus from MRI data. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
These data support the view that heavy drinking exerts a unique and selectively injurious effect on the hippocampus. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Epidemiological data suggest that omega-3 polyunsaturated fatty acids (PUFA) consumption may be inversely correlated to the prevalence and severity of depression but little is known about the underlying mechanisms. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Brain-derived neurotrophic factor (BDNF) plays important roles in activity-dependent plasticity processes, such as long-term potentiation, learning, and memory. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Ts65Dn, a well-characterized animal model for Down syndrome, has three copies of the distal end of mouse chromosome 16 and therefore has segmental trisomy for orthologs for nearly half of the genes located on human chromosome 21. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The effect of depression on the hippocampus has become the focus of a number of structural and functional neuroimaging studies. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Chronic exposure to stress results in a reduction of hippocampal neurogenesis and of hippocampal volume. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Due to its crucial role for memory processes and its relevance in neurological and psychiatric disorders, the hippocampus has been the focus of neuroimaging research for several decades. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
The birth of new neurons, or neurogenesis, in the hippocampal formation has been demonstrated throughout the lifetime of multiple species including humans. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The present results suggest that OXTR might be associated with the susceptibility to ASD, especially in its aspects of social interaction and communication mediated by a modulation of amygdala development, one of the most distributed brain regions with high density of OXTR. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The FDG-positive subgroup showed only hypometabolism, predominantly in AD-sensitive areas extending to the whole neocortex, compared with the FDG-negative subgroup. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
This study examined relations of mesiotemporal lobe tissue volumes with neuropsychological (NP) functions in a sample of patients with first episode schizophrenia. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Neuropathologic and neuroradiologic studies have reported hippocampal abnormalities in schizophrenics. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Reduced hippocampal volume may be suggestive of a risk factor for developing MDD. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Characteristically arising in response to overwhelmingly terrifying events, post-traumatic stress disorder (PTSD) is a disorder of memory: sufferers seemingly relive their trauma in the form of involuntary recollection. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Black-capped chickadees (Parus atricapillus) in upstate New York show a peak in food-hoarding intensity in October. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The concept of cognitive insight was introduced in 2004 to describe the capacity of patients with psychosis to distance themselves from their psychotic experiences, reflect on them, and respond to corrective feedback. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Adult neurogenesis, particularly in the subgranular zone, is thought to be linked with learning and memory. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Longitudinally oriented axon collaterals of CA3 pyramidal cells may be critical for integrating distributed information in the hippocampus. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Recent data suggests that a history of childhood maltreatment is associated with reductions in hippocampal volume in healthy adults. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Application of magnetic resonance imaging (MRI) techniques reveals that human brain aging varies across cortical regions. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Hippocampal volume reduction has been reported in patients with borderline personality disorder (BPD), and is hypothesized to be associated with traumatic childhood experiences. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Extrahippocampal volume abnormalities were bilateral and occurred in both temporal and extra-temporal cortical regions in TLE, whereas hippocampal deficits were related to the side of the epileptogenic focus. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Memory and related cognitive functions are progressively impaired in a subgroup of individuals experiencing childhood adversity and stress. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Where “Free full text” comes from
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
How the 0–100 score works — and why some entries are capped
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
- Journal tier up to 10 pts
- Journal's citation record up to 4 pts
- Study design up to 12 pts
- Strength of evidence up to 5 pts
- Peer-review validation up to 10 pts
- How recent up to 5 pts
- Sample size up to 4 pts
- Effect reported up to 3 pts
- Studied in people up to 3 pts
- Randomised / blinded up to 2 pts
- Times cited up to 7 pts
- Citations per year up to 5 pts
- Impact for its field and year up to 6 pts
- Cited by studies here up to 6 pts
- Still being cited up to 4 pts
- Senior author's track record up to 4 pts
- Institution's track record up to 3 pts
- Multi-centre collaboration up to 3 pts
- Indexed in PubMed up to 2 pts
- Free to read up to 2 pts
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 28,980 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
What this library is — and isn't
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 28,980 records, built mostly from automated pulls of Europe PMC (62.8% of the library) and OpenAlex (17.6%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,038 records (3.6% of the library) are not peer-reviewed — 966 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →