31,380 Alzheimer's and dementia studies in plain English, each scored out of 100.
This finding paves the way for further investigation of the effects of AD risk variants and may become useful for efforts to combine genotypic and phenotypic data for risk prediction and to enrich future prevention trials of AD. 4 key findings →
Participants: 272 Evidence: low
Full summary, score breakdown and related studies → Original source
The macula, located near the center of the retina in the human eye, is responsible for providing critical functions, such as central, sharp vision. 5 key findings →
Participants: 423 Evidence: moderate
Full summary, score breakdown and related studies → Original source
The past few years have been very productive concerning the identification of genes associated with leprosy. 3 key findings →
Design: case-control study Evidence: moderate
Full summary, score breakdown and related studies → Original source
Genetic factors influencing common complex conditions have proven difficult to identify, and data from numerous investigations have provided incomplete conclusions as to the identity of these genes. 2 key findings →
Design: case-control study Evidence: moderate
Full summary, score breakdown and related studies → Original source
High GRS increases the risk of familial LOAD and lowers the age at onset, regardless of ethnic group. 5 key findings →
Evidence: moderate
Full summary, score breakdown and related studies → Original source
Ten-year absolute risk of all-cause dementia increased with age, APOE ɛ4 alleles, GWAS risk alleles, diabetes, low education, and smoking in both women and men. 1 key finding →
Participants: 664 Evidence: low
Full summary, score breakdown and related studies → Original source
The Alzheimer's Disease Sequencing Project (ADSP) performed whole genome sequencing (WGS) of 584 subjects from 111 multiplex families at three sequencing centers. 5 key findings →
Participants: 584 Evidence: low
Full summary, score breakdown and related studies → Original source
Our study suggested that TREM2 (rs75932628-T) was rare in Chinese Han population. 4 key findings →
Design: case-control study Evidence: moderate
Full summary, score breakdown and related studies → Original source
This study comprehensively profiled the AD plasma proteome and serves as a foundation for a high-performance, blood-based test for clinical AD screening and staging. 2 key findings →
Evidence: moderate
Full summary, score breakdown and related studies → Original source
The role of different cell types and their interactions in Alzheimer's disease (AD) is a complex and open question. 2 key findings →
Participants: 24 Evidence: low
Full summary, score breakdown and related studies → Original source
Prion disease is caused by misfolding of the prion protein (PrP) into pathogenic self-propagating conformations, leading to rapid-onset dementia and death. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Peripheral biomarkers of Alzheimer's disease (AD) reflecting early neuropathological change are critical to the development of treatments for this condition. 3 key findings →
Participants: 27 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Early-onset (age < 65) Alzheimer's disease is associated with greater non-amnestic cognitive symptoms and neuropathological burden than late-onset disease. 5 key findings →
Participants: 60 Evidence: low
Full summary, score breakdown and related studies → Original source
Patients with Alzheimer's disease (AD) with little or no quantifiable insoluble brain tau neurofibrillary tangle (NFT) pathology demonstrate stronger clinical benefits of therapies than those with advanced NFTs. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
NPS are predominantly related to tau in aging and dementia. 2 key findings →
Evidence: moderate
Full summary, score breakdown and related studies → Original source
In MCI/AD patients, [ 18 F]flortaucipir binding in entorhinal, limbic, and neocortical regions was associated with cortical atrophy. 5 key findings →
Participants: 100 Evidence: low
Full summary, score breakdown and related studies → Original source
Multi-compartment modelling of white matter microstructure using Neurite Orientation Dispersion and Density Imaging (NODDI) can provide information on white matter health through neurite density index and free water measures. 5 key findings →
Evidence: moderate
Full summary, score breakdown and related studies → Original source
These findings highlight our technology's unbiased capability to identify topologies of 3R + 4R versus 4R tau deposits. © 2022 The Authors. 3 key findings →
Participants: 46 Evidence: low
Full summary, score breakdown and related studies → Original source
Despite epidemiological and genetic data linking semantic dementia to inflammation, the topography of neuroinflammation in semantic dementia, also known as the semantic variant of primary progressive aphasia, remains unclear. 1 key finding →
Participants: 12 Evidence: low
Full summary, score breakdown and related studies → Original source
A next generation of tau PET tracers for the imaging of Alzheimer's disease and other dementias has recently been developed. 2 key findings →
Evidence: moderate
Full summary, score breakdown and related studies → Original source
18 F-AV1451 prominently specific binding was found in the amygdala, entorhinal cortex, parahippocampus, fusiform, posterior cingulate, temporal, parietal, and frontal brain regions. 5 key findings →
Participants: 115 Evidence: low
Full summary, score breakdown and related studies → Original source
Posterior cortical atrophy (PCA), usually an atypical clinical syndrome of Alzheimer's disease, has well-characterized patterns of cortical atrophy and tau deposition that are distinct from typical amnestic presentations of Alzheimer's disease. 5 key findings →
Design: cross-sectional Evidence: low
Full summary, score breakdown and related studies → Original source
Visually preserved metabolism in posterior cingulate cortex relative to hypometabolism in precuneus and cuneus, the cingulate island sign , is a feature of dementia with Lewy bodies (DLB) on FDG-PET. 4 key findings →
Participants: 114 Evidence: low
Full summary, score breakdown and related studies → Original source
3 H-flortaucipir demonstrated a positive signal in all CTE cases examined, with varying degrees of specific binding (68.7% ± 10.5%; n = 12) defined by homologous blockade and to a lesser extent by heterologous blockade with MK-6240 (27.3% ± 13.6%; n = 12). 3 key findings →
Participants: 12 Evidence: low
Full summary, score breakdown and related studies → Original source
Their location may relate to the type of underlying small vessel pathology: those in the white matter centrum semi-ovale have been associated with cerebral amyloid angiopathy, while those in the basal ganglia have been associated with deep perforating artery arteriolosclerosis. 5 key findings →
Participants: 110 Evidence: low
Full summary, score breakdown and related studies → Original source
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 31,380 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 31,380 records, built mostly from automated pulls of Europe PMC (65.6% of the library) and OpenAlex (16.2%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,048 records (3.3% of the library) are not peer-reviewed — 973 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →
Newest studies, as a dated timeline → Atom feed Where this research is being discussed: events