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Research

28,580 Alzheimer's and dementia studies in plain English, each scored out of 100.

Find studies

Showing 76–100 of 143 studies scoring ≥ 67 out of 100 published 2017 (page 4 of 6) · 28,580 in the whole library · How the 0–100 score works

Download bibliography of these 143 studies, in this order: BibTeX (.bib) · RIS (.ris)

Browse by subject, author or institution

Each number is how many studies that link shows, with your other filters kept.

Subjects

Authors

Names as each record prints them; the same person can appear under two spellings.

Institutions

From OpenAlex; 14,058 studies have no institution on record and are not counted here.

A note on reading research. One study is rarely the final word.

We try to note the size of a study, whether it was in humans or animals, and how early-stage the finding is. If a summary here doesn't make that clear, treat it with extra caution and check the original source.

A Comparison of the Prevalence of Dementia in the United States in 2000 and 2012

✓ Peer-reviewed alzhub usefulness score 71 out of 100. JAMA internal medicine 2017-01-01

The study cohorts had an average age of 75.0 years (95% CI, 74.8-75.2 years) in 2000 and 74.8 years (95% CI, 74.5-75.1 years) in 2012 (P = .24); 58.4% (95% CI, 57.3%-59.4%) of the 2000 cohort was female compared with 56.3% (95% CI, 55.5%-57.0%) of the 2012 cohort (P Conclusions and relevance The prevalence of dementia in the United States declined significantly between 2000 and 2012. 4 key findings →

Design: longitudinal study Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

The impact of individual Cognitive Stimulation Therapy (iCST) on cognition, quality of life, caregiver health, and family relationships in dementia: A randomised controlled trial

✓ Peer-reviewed alzhub usefulness score 71 out of 100. PLoS medicine 2017-03-28

Cognitive stimulation therapy (CST) is a well-established group psychosocial intervention for people with dementia. 4 key findings →

Design: randomized controlled trial Evidence: high

Full summary, score breakdown and related studies → Original source Free full text

Predictors of emergency department attendance by people with dementia in their last year of life: Retrospective cohort study using linked clinical and administrative data

✓ Peer-reviewed alzhub usefulness score 71 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2017-08-22

ED attendance in the last year of life for people with dementia is common and is increasing. 2 key findings →

Design: cohort study Participants: 4,867 Evidence: moderate

Full summary, score breakdown and related studies → Original source

Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers

✓ Peer-reviewed alzhub usefulness score 71 out of 100. Acta neuropathologica 2017-02-28

More than 20 genetic loci have been associated with risk for Alzheimer's disease (AD), but reported genome-wide significant loci do not account for all the estimated heritability and provide little information about underlying biological mechanisms. 5 key findings →

Design: case-control study Participants: 3,146 Evidence: moderate

Full summary, score breakdown and related studies → Original source

Optimizing the preclinical Alzheimer's cognitive composite with semantic processing: The PACC5

✓ Peer-reviewed alzhub usefulness score 71 out of 100. Alzheimer's & dementia (New York, N. Y.) 2017-11-10

Addition of CAT to the PACC provides unique information about early cognitive decline not currently captured by the episodic memory, executive function, and global cognition components and may therefore improve detection of early Aβ-related cognitive decline. 1 key finding →

Design: longitudinal study Participants: 70 Evidence: moderate

Full summary, score breakdown and related studies → Original source

Association of Lithium in Drinking Water With the Incidence of Dementia

✓ Peer-reviewed alzhub usefulness score 71 out of 100. JAMA Psychiatry 2017-08-25

A total of 73 731 patients with dementia and 733 653 controls (median age, 80.3 years; interquartile range, 74.9-84.6 years; 44 760 female [60.7%] and 28 971 male [39.3%]) were included in the study. 5 key findings →

Design: case-control study Participants: 731 Evidence: moderate

Full summary, score breakdown and related studies → Original source

Behavioral Interventions to Prevent or Delay Dementia: Protocol for a Randomized Comparative Effectiveness Study

✓ Peer-reviewed alzhub usefulness score 71 out of 100. JMIR research protocols 2017-11-27

This paper describes the protocol for a randomized comparative effectiveness study of behavioral interventions to prevent or delay dementia. 2 key findings →

Design: longitudinal study Participants: 300 Evidence: high

Full summary, score breakdown and related studies → Original source

Trajectories of Depressive Symptoms Before Diagnosis of Dementia: A 28-Year Follow-up Study

✓ Peer-reviewed alzhub usefulness score 70 out of 100. JAMA psychiatry 2017-07-01

Those reporting depressive symptoms in 1985 (mean follow-up, 27 years) did not have significantly increased risk for dementia (hazard ratio [HR], 1.21; 95% CI, 0.95-1.54) in Cox regression adjusted for sociodemographic covariates, health behaviors, and chronic conditions. 5 key findings →

Design: cohort study Participants: 322 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Unravelling positive aspects of caregiving in dementia: An integrative review of research literature

✓ Peer-reviewed alzhub usefulness score 70 out of 100. International journal of nursing studies 2017-10-16

The findings of this review provide insight into catalysing the paradigm shift from 'reducing stress' to 'optimising positive experience' in developing caregiving support services for dementia, and may guide future empirical study to explain this unique dimension of caregiving experience. 2 key findings →

Design: cohort study Participants: 3,862 Evidence: moderate

Full summary, score breakdown and related studies → Original source Full text may need a subscription

Association of Delirium With Cognitive Decline in Late Life: A Neuropathologic Study of 3 Population-Based Cohort Studies

✓ Peer-reviewed alzhub usefulness score 70 out of 100. JAMA psychiatry 2017-03-01

There were 987 participants (290 from Vantaa 85+, 241 from the Cambridge City Over-75s Cohort, and 456 from the Cognitive Function and Ageing Study) with neuropathologic data; mean (SD) age at death was 90 (6.4) years, including 682 women (69%). 5 key findings →

Design: cohort study Participants: 987 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Living near major roads and the incidence of dementia, Parkinson's disease, and multiple sclerosis: a population-based cohort study

✓ Peer-reviewed alzhub usefulness score 70 out of 100. Lancet (London, England) 2017-01-05

Between 2001, and 2012, we identified 243 611 incident cases of dementia, 31 577 cases of Parkinson's disease, and 9247 cases of multiple sclerosis. 3 key findings →

Design: cohort study Evidence: moderate

Full summary, score breakdown and related studies → Original source Full text may need a subscription

In vivo staging of regional amyloid deposition

✓ Peer-reviewed alzhub usefulness score 70 out of 100. Neurology 2017-10-18

The highly consistent regional hierarchy of PET-evidenced amyloid deposition across participants resembles neuropathologic observations and suggests a predictable regional sequence that may be used to stage an individual's progress of amyloid pathology in vivo. 2 key findings →

Design: cross-sectional Participants: 667 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Incremental value of biomarker combinations to predict progression of mild cognitive impairment to Alzheimer's dementia

✓ Peer-reviewed alzhub usefulness score 70 out of 100. Alzheimer's research & therapy 2017-10-10

ROC curves of the five best two-, three-, and four-parameter combinations were analyzed for significant superiority by a bootstrapping wrapper around a support vector machine with linear kernel. 4 key findings →

Design: cohort study Participants: 115 Evidence: moderate

Full summary, score breakdown and related studies → Original source

A randomized controlled trial of disclosing genetic risk information for Alzheimer disease via telephone

✓ Peer-reviewed alzhub usefulness score 69 out of 100. Genetics in medicine : official journal of the American College of Medical Genetics 2017-07-20

PurposeTelephone disclosure of genetic test results can improve access to services. 4 key findings →

Participants: 257 Evidence: high

Full summary, score breakdown and related studies → Original source Free full text

Mediterranean diet and cognitive health: Initial results from the Hellenic Longitudinal Investigation of Ageing and Diet

✓ Peer-reviewed alzhub usefulness score 69 out of 100. PloS one 2017-08-01

Our results suggest that adherence to the MeDi is associated with better cognitive performance and lower dementia rates in Greek elders. 5 key findings →

Design: longitudinal study Participants: 1,865 Evidence: moderate

Full summary, score breakdown and related studies → Original source Free full text

Lifestyle for Brain Health (LIBRA): a new model for dementia prevention

✓ Peer-reviewed alzhub usefulness score 69 out of 100. International journal of geriatric psychiatry 2017-02-28

Lifestyle for Brain Health (LIBRA) may help in identifying and monitoring risk status in dementia-prevention programmes, by targeting modifiable, lifestyle-related risk factors. 2 key findings →

Design: systematic review Participants: 949 Evidence: high

Full summary, score breakdown and related studies → Original source Free full text

Effects of the Insulin Sensitizer Metformin in Alzheimer Disease: Pilot Data From a Randomized Placebo-controlled Crossover Study

✓ Peer-reviewed alzhub usefulness score 69 out of 100. Alzheimer disease and associated disorders 2017-04-01

Epidemiological studies have identified a robust association between type II diabetes mellitus and Alzheimer disease (AD), and neurobiological studies have suggested the presence of central nervous system insulin resistance in individuals with AD. 3 key findings →

Evidence: high

Full summary, score breakdown and related studies → Original source Free full text

The Utilization of Robotic Pets in Dementia Care

✓ Peer-reviewed alzhub usefulness score 69 out of 100. Journal of Alzheimer's disease : JAD 2017-01-01

Treatment with the PARO robot decreased stress and anxiety in the treatment group and resulted in reductions in the use of psychoactive medications and pain medications in elderly clients with dementia. 2 key findings →

Participants: 61 Evidence: high

Full summary, score breakdown and related studies → Original source Free full text

Effects of computerized cognitive training on neuroimaging outcomes in older adults: a systematic review

✓ Peer-reviewed alzhub usefulness score 69 out of 100. BMC geriatrics 2017-07-10

Of all studies included in this systematic review, results from the highest quality studies, which were two randomized controlled trials, demonstrated that multi-domain CCT could lead to increases in hippocampal functional connectivity. 5 key findings →

Design: systematic review Evidence: high

Full summary, score breakdown and related studies → Original source

Intradialytic Cognitive and Exercise Training May Preserve Cognitive Function

✓ Peer-reviewed alzhub usefulness score 69 out of 100. Kidney international reports 2017-08-19

Preliminary findings of our pilot study suggested that cognitive decline in psychomotor speed and executive function is possibly prevented by intradialytic CT and ET. 4 key findings →

Design: randomized controlled trial Evidence: high

Full summary, score breakdown and related studies → Original source

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Where “Free full text” comes from

Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read

How the 0–100 score works — and why some entries are capped

This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.

  • Journal tier up to 10 pts
  • Journal's citation record up to 4 pts
  • Study design up to 12 pts
  • Strength of evidence up to 5 pts
  • Peer-review validation up to 10 pts
  • How recent up to 5 pts
  • Sample size up to 4 pts
  • Effect reported up to 3 pts
  • Studied in people up to 3 pts
  • Randomised / blinded up to 2 pts
  • Times cited up to 7 pts
  • Citations per year up to 5 pts
  • Impact for its field and year up to 6 pts
  • Cited by studies here up to 6 pts
  • Still being cited up to 4 pts
  • Senior author's track record up to 4 pts
  • Institution's track record up to 3 pts
  • Multi-centre collaboration up to 3 pts
  • Indexed in PubMed up to 2 pts
  • Free to read up to 2 pts

Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.

Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.

We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.

The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.

See the whole rubric drawn out → — four charts covering all 28,580 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.

What this library is — and isn't

This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 28,580 records, built mostly from automated pulls of Europe PMC (62.2% of the library) and OpenAlex (17.8%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.

1,034 records (3.6% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.

See the full, machine-readable breakdown of this library's coverage →

Newest studies, as a dated timeline →    Atom feed