TDP-43 proteinopathies are characterized by loss of nuclear TDP-43 and accumulation of the protein in the cytosol as ubiquitinated protein aggregates. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Research
27,380 Alzheimer's and dementia studies in plain English, each scored out of 100.
Delirium is a common and severe neuropsychiatric syndrome characterised by acute deterioration and fluctuations in mental status. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
This report reviews evidence on disorders related to inadequate vitamin D repletion in older people. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Hypertension, a powerful risk factor for stroke and dementia, has damaging effects on the brain and its vessels. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
36/100
Falls are common events in the elderly and represent the main risk factor for fractures and other injuries. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Older people reaching end-of-life status are particularly at risk of adverse effects of drug therapy. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The number of people with dementia is growing at an alarming rate. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
We recommend the EOLD-SWC to measure QOC, and the EOLD-CAD and MSSE to measure QOD in populations with dementia and in mixed long term care populations of nursing home or residential care home/assisted living residents, because they performed best in both countries. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The caregiving stressor is associated with considerable psychological vulnerability, sleep disorders, and risk of alterations in the cardiovascular system, which seem to be modulated by caregiving characteristics. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The experience of being a carer of a person with dementia at the end of life is expressed in these 12 accounts. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Concerning pain assessment, the findings of this review suggest that self-report pain rating scales, in particular the Verbal Rating Scale, the Horizontal Visual Analogue Scale and the Faces Pain Scale can be administered to patients in a more advanced stage of dementia. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Several areas of end-of-life care provision could be improved. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Providing artificial feeding and fluids and discussing euthanasia may be particularly sensitive topics, and guidance on these subjects needs careful consideration of ethical aspects and possible adaptations to local standards and practice. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Because previous research favored care in the Netherlands to that in the United States, findings suggest improvement in end-of-life care and outcomes in the United States and stability in the Netherlands. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Chronic pain patients exhibit increased anxiety, depression, and deficits in learning and memory. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The prefrontal cortex (PFC) regulates emotional responses, but it is unclear how PFC integrates diverse inputs to select the appropriate response. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Obstructive sleep apnea syndrome (OSAS) is a common disorder with far-reaching health implications. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
If adequate MRI shows no structural correlate in patients with MTLE, functional imaging studies are valuable, especially if they are in agreement with ictal electroencephalography (EEG) findings. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
A growing number of structural neuroimaging studies have reported significant changes in gray matter density or volume and white matter microstructure in the adult human brain following training. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Recent epidemiological and experimental studies suggest a link between cognitive decline in late adulthood and sports concussions sustained in early adulthood. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Increased sensitivity to stress is known to play an important role in the transition to first episode psychosis (FEP). 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Recent studies suggest that a complex, distributed neural network underpins semantic cognition. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
We analyze the relationship between age of survival, morbidity, and disability among centenarians (age 100-104 years), semisupercentenarians (age 105-109 years), and supercentenarians (age 110-119 years). 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
36/100
The elderly are the most rapidly growing population group in the world. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Interest in dementia has increased over the past few decades. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Where “Free full text” comes from
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
How the 0–100 score works — and why some entries are capped
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
- Journal tier up to 10 pts
- Journal's citation record up to 4 pts
- Study design up to 12 pts
- Strength of evidence up to 5 pts
- Peer-review validation up to 10 pts
- How recent up to 5 pts
- Sample size up to 4 pts
- Effect reported up to 3 pts
- Studied in people up to 3 pts
- Randomised / blinded up to 2 pts
- Times cited up to 7 pts
- Citations per year up to 5 pts
- Impact for its field and year up to 6 pts
- Cited by studies here up to 6 pts
- Still being cited up to 4 pts
- Senior author's track record up to 4 pts
- Institution's track record up to 3 pts
- Multi-centre collaboration up to 3 pts
- Indexed in PubMed up to 2 pts
- Free to read up to 2 pts
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 27,380 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
What this library is — and isn't
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,380 records, built mostly from automated pulls of Europe PMC (60.6% of the library) and OpenAlex (18.6%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,032 records (3.8% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →