27,780 Alzheimer's and dementia studies in plain English, each scored out of 100.
Among 1,706 participants (mean age 56 years, 62% female, 28% Black), midlife NAFLD vs no NAFLD was associated with greater late-life WMH volume (difference per SD 0.19, 95% CI 0.06-0.31) and faster late-life WMH increase over 6 years (difference in annual change, SD 0.28, 95% CI 0.05-0.51), suggesting accumulating vascular pathology. 5 key findings →
Participants: 1,706 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
In the whole sample, both PRSs were associated with the strength of correlation between GMV and different serotonin receptors and fluorodopa uptake. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Research revealed a significant locus of susceptibility for LOAD on the Bridging Integrator 1 (BIN1) that is situated on chromosome 2q14.3 and is identified at the time of the most significant susceptibility gene of LOAD. 2 key findings →
Participants: 110 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Genome-wide association studies (GWASs) have identified thousands of putative disease-causing variants with unknown regulatory effects. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Within the limitations of measuring in vitro equilibrium binding activity of in‐house recombinant antibodies to aqueously extracted Aβ from human postmortem brain tissue, we could not discern a population of Aβ aggregates ( e.g . protofibrils) accessible to one antibody but not the other two. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
The anti-amyloid monoclonal antibody lecanemab received the US accelerated approval for mild cognitive impairment or mild dementia stage of Alzheimer disease in January 2023, which was converted into traditional approval in June 2023. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Our results show that lecanemab exhibits high binding affinity to amyloid-β fibril structures that have a flexible N-terminus in common, as is the case for type I, type II and murine type III amyloid-β fibril polymorphs, which resemble or are identical to human structures observed in sporadic and familial cases of Alzheimer's disease, including a case with the Arctic (E22G) mutation. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Die amyloide Selbstassemblierung von α‐Synuclein (αSyn) wird mit der Pathogenese der Parkinson‐Krankheit (PD) in Verbindung gebracht. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Disaster risk reduction efforts in the education sector not only create a safer environment but also encourage sustainable development. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Mean performance on knowledge of dementia risk factor mitigation strategies significantly increased after viewing the animation (p < .001), with a clinically meaningful effect (mean change = 3.63). 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Full text may need a subscription
The construction sector is among the most dangerous industries, recognized for its significant rate of accidents with even more serious consequences, especially in developing countries. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
This paper explores the role of CSR in risk mitigation within an increasingly ESG-focused environment. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
acceptability, appropriateness, and feasibility. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Data from both pilot studies are reported including item analysis and quantitative and qualitative results. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
This study aims to investigate the syntactic complexity in individuals with Alzheimer's disease (AD) by conducting a comprehensive analysis that incorporates mean dependency distance (MDD), fine-grained grammatical metrics, and dependency network structures. 3 key findings →
Participants: 150 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Sixty studies were identified. Mental and physical effects caused by caregivers' sleep deprivation have been observed. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Full text may need a subscription
The present study addresses the perspectives of Israeli family caregivers and migrant care workers on behavioral problems of persons with dementia. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
The TLC study used an appropriate design and data collection procedures, along with acceptable recruitment capability. 5 key findings →
Participants: 15 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Four themes were identified, along with eleven sub-themes associated with them: cognitive-behavioral shift (transitioning family roles, recognizing disease characteristics, focusing on health management, and responding positively and effectively); personal strength enhancement (enhancing coping capacity, increased psychological resilience and increased responsibility); improved relationships with others (harmonizing in family relations and benefiting from social interactions); and changes in life perceptions (reshaping of values, and reconstructing the meaning of life). 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
The study found significant correlations between caregiver competence, QoL, and burden/stress with the QoL of individuals with dementia. 4 key findings →
Design: cross-sectional Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
As the rates of Alzheimer's disease (AD) and AD and related dementias (ADRD) in the United States steadily rise, so too does the demand for informal caregiving. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
The findings revealed that Japanese physicians did not display support for euthanasia (2%) and assisted suicide (1%); however, the general public supported euthanasia (33%) and assisted suicide (34%). 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Dementia cases are projected to triple globally by 2050, largely driven by an aging population. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Compared to persons without IDD, cumulative incidence of dementia was on average 4.27 and 5.33 times higher in persons with Non-DS IDD and DS respectively and period prevalence of dementia was on average 4.87 and 5.93 times higher in persons with Non-DS IDD and DS respectively. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 27,780 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,780 records, built mostly from automated pulls of Europe PMC (61.1% of the library) and OpenAlex (18.3%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,034 records (3.7% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →