Fourteen cohorts including 726,900 participants were analyzed. 5 key findings →
Design: meta-analysis Participants: 726,900 Evidence: high
Full summary, score breakdown and related studies → Original source
Research
28,180 Alzheimer's and dementia studies in plain English, each scored out of 100.
As visual impairment, cataract, and diabetic retinopathy are associated with an increased likelihood of developing dementia, early diagnosis may help identify those at risk of dementia. 5 key findings →
Design: meta-analysis Participants: 37,705 Evidence: high
Full summary, score breakdown and related studies → Original source
Among 10 095 participants (67.3% men; aged 35-55 years in 1985-1988), a total of 1710 cases of diabetes and 639 cases of dementia were recorded over a median follow-up of 31.7 years. 3 key findings →
Design: cohort study Participants: 95 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
Decades of research have revealed numerous risk factors for mental disorders beyond genetics, but their consistency and magnitude remain uncer-tain. 1 key finding →
Design: meta-analysis Participants: 176 Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
A relationship between sleep disorders and cognitive dysfunctions was reported in Parkinson's Disease (PD), however, some studies did not confirm the link. 4 key findings →
Design: meta-analysis Participants: 54 Evidence: high
Full summary, score breakdown and related studies → Original source
In this cohort study of US Medicare beneficiaries, dual sensory impairment was prevalent in older adults and associated with increased risk of dementia. 5 key findings →
Design: cohort study Participants: 7,562 Evidence: moderate
Full summary, score breakdown and related studies → Original source
74/100
Topic Visual impairment (VI) and cognitive impairment (CIM) are prevalent age-related conditions that impose substantial burden on the society. 5 key findings →
Design: systematic review Participants: 47 Evidence: high
Full summary, score breakdown and related studies → Original source
Late-life depression (LLD), compared to depression at a young age, is more likely to have poor prognosis and high risk of progression to dementia. 4 key findings →
Design: meta-analysis Evidence: high
Full summary, score breakdown and related studies → Original source
71/100
Both HL and depression are independent risk factors for eventual conversion to dementia. 2 key findings →
Design: longitudinal study Participants: 8,529 Evidence: moderate
Full summary, score breakdown and related studies → Original source
71/100
HI and VI at baseline were reported by 30.3% and 16.6% of individuals, respectively. 5 key findings →
Design: cohort study Participants: 3,497 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Among 952 participants (mean age at first neuropsychological assessment = 69±8 years, 62% women, 17% Black, 13% white, 68% Hispanic), 24% developed MCI/dementia. 4 key findings →
Design: longitudinal study Participants: 952 Evidence: moderate
Full summary, score breakdown and related studies → Original source
10-year average (SD) PM2.5 from death across the autopsy cohort was 8.2 (1.9) μg/m3. 5 key findings →
Design: cohort study Participants: 832 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Prediabetes was positively associated with risk of all-cause mortality and the incidence of cardiovascular outcomes, CHD, stroke, chronic kidney disease, cancer and dementia. 4 key findings →
Design: meta-analysis Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
Screening for IC impairments identifies older adults at higher risk of incident frailty and incident IADL/ADL disability. 3 key findings →
Design: longitudinal study Participants: 759 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Overall, 7124 participants representative of Medicare beneficiaries 65 years or older were included. 5 key findings →
Design: cross-sectional Participants: 7,124 Evidence: moderate
Full summary, score breakdown and related studies → Original source
A total of 3,056 participants without diabetes treatment and 480 with diabetes treatment were included (mean age at baseline, 75.1 years; mean 7.5 years of follow-up). 5 key findings →
Design: cohort study Participants: 3,056 Evidence: moderate
Full summary, score breakdown and related studies → Original source
We report 1,136 cases of incident dementia among 4,166 individuals with nonmissing APOE status. 5 key findings →
Design: cohort study Participants: 4,166 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Delirium is the most common manifestation of brain dysfunction in critically ill patients. 5 key findings →
Participants: 25,000 Evidence: low
Full summary, score breakdown and related studies → Original source Free full text
Of 6 952 440 vaccinated patients in the derivation cohort, 5 150 310 (74.1%) had two vaccine doses. 4 key findings →
Design: cohort study Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
Telemedicine is well received among patients and care partners, but successful delivery incorporates support staff and the care partners to navigate technologies. 2 key findings →
Design: systematic review Evidence: high
Full summary, score breakdown and related studies → Original source
At baseline, DSI was significantly associated with increased dementia prevalence compared to normal sensory function (odds ratio [OR] 2.17, 95% confidence interval [CI] 1.17-4.02), but SSI was not (OR 1.27, 95% CI 0.66-2.41). 4 key findings →
Design: cohort study Evidence: moderate
Full summary, score breakdown and related studies → Original source
Strong conclusions remain elusive, although the weight of the evidence suggests an adverse association between PM2.5 and cognitive decline. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Cognitive impairment associated with aging is a serious and growing public health problem. 2 key findings →
Design: longitudinal study Evidence: moderate
Full summary, score breakdown and related studies → Original source
Late-life depression remains an underdiagnosed clinical entity, mainly because the presence of cognitive impairment in the elderly leads clinicians to suspect dementia rather than depression. 3 key findings →
Design: longitudinal study Participants: 72 Evidence: moderate
Full summary, score breakdown and related studies → Original source
The PSI was higher in Kaohsiung and compared with Pingtung patients, Kaohsiung patients were exposed to higher average annual concentrations of CO, NO2, PM10, and SO2. 5 key findings →
Design: case-control study Participants: 704 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Where “Free full text” comes from
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
How the 0–100 score works — and why some entries are capped
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
- Journal tier up to 10 pts
- Journal's citation record up to 4 pts
- Study design up to 12 pts
- Strength of evidence up to 5 pts
- Peer-review validation up to 10 pts
- How recent up to 5 pts
- Sample size up to 4 pts
- Effect reported up to 3 pts
- Studied in people up to 3 pts
- Randomised / blinded up to 2 pts
- Times cited up to 7 pts
- Citations per year up to 5 pts
- Impact for its field and year up to 6 pts
- Cited by studies here up to 6 pts
- Still being cited up to 4 pts
- Senior author's track record up to 4 pts
- Institution's track record up to 3 pts
- Multi-centre collaboration up to 3 pts
- Indexed in PubMed up to 2 pts
- Free to read up to 2 pts
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 28,180 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
What this library is — and isn't
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 28,180 records, built mostly from automated pulls of Europe PMC (61.7% of the library) and OpenAlex (18.1%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,034 records (3.7% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →