White matter deterioration is associated with cognitive impairment in healthy aging and Alzheimer's disease. 3 key findings →
Participants: 180 Evidence: low
Full summary, score breakdown and related studies → Original source
Research
27,780 Alzheimer's and dementia studies in plain English, each scored out of 100.
To effectively combat dementia onset and progression, lifestyle-based interventions targeting multiple risk factors and disease mechanisms through a multidomain approach - tailored and implemented early in the disease process - have emerged as promising. 1 key finding →
Evidence: high
Full summary, score breakdown and related studies → Original source
Despite differences in CVR management within the countries considered, it was possible to design and implement the HATICE multidomain intervention. 4 key findings →
Design: randomized controlled trial Evidence: high
Full summary, score breakdown and related studies → Original source
70/100
After 12 weeks, maintenance of executive functioning in the TG was found, yet no significant changes on circulating neurotrophins levels were identified. 3 key findings →
Participants: 16 Evidence: low
Full summary, score breakdown and related studies → Original source
This review is anticipated to yield clinically meaningful insight on the specific value of exercise for older adults with AD. 3 key findings →
Design: systematic review Evidence: high
Full summary, score breakdown and related studies → Original source
This critical review explores the review material on physical activity combined with cognitive stimulation interventions in older adults with cognitive impairment and/or dementia. 1 key finding →
Design: systematic review Evidence: high
Full summary, score breakdown and related studies → Original source
Long-term adherence to the MIND diet was moderately associated with better verbal memory in later life. 2 key findings →
Design: cohort study Participants: 16,058 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Technology-based cognitive training and rehabilitation interventions show promise, but the findings were inconsistent due to the variations in study design. 2 key findings →
Design: systematic review Evidence: high
Full summary, score breakdown and related studies → Original source
In an elderly population of Southern Italy with a typical Mediterranean diet, high MUFA intakes appeared to be protective against age-related cognitive decline. 2 key findings →
Design: longitudinal study Participants: 704 Evidence: high
Full summary, score breakdown and related studies → Original source
These findings challenge current management practices of Alzheimer's patients. 4 key findings →
Evidence: high
Full summary, score breakdown and related studies → Original source
There is a lack of high-quality research in this field. 5 key findings →
Design: meta-analysis Evidence: high
Full summary, score breakdown and related studies → Original source
Cognition-oriented treatments - commonly categorized as cognitive training, cognitive rehabilitation and cognitive stimulation - are promising approaches for the prevention of cognitive and functional decline in older adults. 1 key finding →
Design: meta-analysis Evidence: high
Full summary, score breakdown and related studies → Original source
Higher "vegetables-fruits" and "snacks-drinks-milk products" pattern scores were associated with reduced risk of cognitive impairment in Chinese older women in Hong Kong. 5 key findings →
Design: cohort study Participants: 221 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Of all studies included in this systematic review, results from the highest quality studies, which were two randomized controlled trials, demonstrated that multi-domain CCT could lead to increases in hippocampal functional connectivity. 5 key findings →
Design: systematic review Evidence: high
Full summary, score breakdown and related studies → Original source
Nine studies were eligible for inclusion. 2 key findings →
Design: longitudinal study Evidence: high
Full summary, score breakdown and related studies → Original source
Multi-model cognitive training help MCI patients to gained cognition benefit, especially in memory, attention and executive function. 4 key findings →
Participants: 78 Evidence: low
Full summary, score breakdown and related studies → Original source
Twelve studies with 195 PwD and four with 53 PwMCI met the inclusion criteria. 5 key findings →
Design: systematic review Evidence: high
Full summary, score breakdown and related studies → Original source
Preliminary findings of our pilot study suggested that cognitive decline in psychomotor speed and executive function is possibly prevented by intradialytic CT and ET. 4 key findings →
Design: randomized controlled trial Evidence: high
Full summary, score breakdown and related studies → Original source
CrExp therapy has greater positive effects on cognitive functions and daily living ability than standard cognitive training. 1 key finding →
Participants: 93 Evidence: low
Full summary, score breakdown and related studies → Original source
Future interventions should address subjective fatigue when managing cognitive and functional abilities in community-dwelling older adults. 3 key findings →
Design: cohort study Evidence: high
Full summary, score breakdown and related studies → Original source
A program of cognitive training improves cognitive functioning over time. 4 key findings →
Participants: 23 Evidence: low
Full summary, score breakdown and related studies → Original source
69/100
The age of the population is shifting toward the elderly range, which may lead to an increased risk of mild cognitive impairment (MCI). 5 key findings →
Participants: 70 Evidence: low
Full summary, score breakdown and related studies → Original source
As aging is associated with cognitive decline, particularly in the executive functions, it is essential to effectively improve cognition in older adults. 4 key findings →
Design: randomized controlled trial Evidence: high
Full summary, score breakdown and related studies → Original source
MBSR is well-accepted potentially promising intervention with positive effect on cognition, depressive symptoms and immunological profile. 5 key findings →
Participants: 12 Evidence: low
Full summary, score breakdown and related studies → Original source
In Hong Kong, the evidence for cognitive-training programs in fighting against memory complaints is lacking. 2 key findings →
Participants: 200 Evidence: low
Full summary, score breakdown and related studies → Original source
Where “Free full text” comes from
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
How the 0–100 score works — and why some entries are capped
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
- Journal tier up to 10 pts
- Journal's citation record up to 4 pts
- Study design up to 12 pts
- Strength of evidence up to 5 pts
- Peer-review validation up to 10 pts
- How recent up to 5 pts
- Sample size up to 4 pts
- Effect reported up to 3 pts
- Studied in people up to 3 pts
- Randomised / blinded up to 2 pts
- Times cited up to 7 pts
- Citations per year up to 5 pts
- Impact for its field and year up to 6 pts
- Cited by studies here up to 6 pts
- Still being cited up to 4 pts
- Senior author's track record up to 4 pts
- Institution's track record up to 3 pts
- Multi-centre collaboration up to 3 pts
- Indexed in PubMed up to 2 pts
- Free to read up to 2 pts
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 27,780 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
What this library is — and isn't
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,780 records, built mostly from automated pulls of Europe PMC (61.1% of the library) and OpenAlex (18.3%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,034 records (3.7% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →