27,780 Alzheimer's and dementia studies in plain English, each scored out of 100.
Among cognitively unimpaired participants with a family history of dementia, changes in cognition and brain MRI outcomes from baseline to year 3 did not differ significantly between those who followed the MIND diet and those who followed the control diet with mild caloric restriction. 5 key findings →
Design: RCT Participants: 604 Evidence: null result
Full summary, score breakdown and related studies → Original source Free full text
Modifiable vascular and lifestyle-related risk factors have been associated with dementia risk in observational studies. 4 key findings →
Design: randomized controlled trial Participants: 631 Evidence: high
Full summary, score breakdown and related studies → Original source Full text may need a subscription
These findings suggest that a hearing intervention might reduce cognitive change over 3 years in populations of older adults at increased risk for cognitive decline but not in populations at decreased risk for cognitive decline. 5 key findings →
Design: randomized controlled trial Participants: 858 Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
Significant study-site, specimen type, and batch effects were observed. 5 key findings →
Design: randomized controlled trial Participants: 604 Evidence: high
Full summary, score breakdown and related studies → Original source
Epidemiologic studies suggest that a Mediterranean diet, an antioxidant-rich cardioprotective dietary pattern, delays cognitive decline, but clinical trial evidence is lacking. 5 key findings →
Design: RCT Participants: 447 Evidence: moderate
Full summary, score breakdown and related studies → Original source Free full text
Dementia is a leading cause of death and disability worldwide. 3 key findings →
Design: RCT Participants: 33,995 Evidence: high
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The hippocampus shrinks in late adulthood, leading to impaired memory and increased risk for dementia. 4 key findings →
Design: randomized controlled trial Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
This randomized trial followed 2,111 older adults at risk for cognitive decline across 5 US sites for two years, comparing a highly structured lifestyle program (regular exercise, MIND diet, cognitive/social engagement, health coaching) against a lower-intensity, self-guided version of the same components. 4 key findings →
Design: RCT Participants: 2,111 Evidence: moderate
Full summary, score breakdown and related studies → Original source
This long-term follow-up of the SPRINT randomized trial tested whether intensively lowering systolic blood pressure (to below 120, vs. the standard target of below 140) reduces the risk of thinking problems in adults 50+ with hypertension. 4 key findings →
Design: RCT Participants: 9,361 Evidence: moderate
Full summary, score breakdown and related studies → Original source
This Finnish randomized controlled trial was the first large study to show that a two-year program combining diet counseling, exercise, cognitive training, and monitoring of heart-health risk factors could help maintain or improve thinking skills in older adults at elevated dementia risk, compared with a control group who received only general health advice. 3 key findings →
Design: RCT Participants: 1,260 Evidence: high
Full summary, score breakdown and related studies → Original source
A long-term intervention with an EVOO-rich MedDiet resulted in a better cognitive function in comparison with a control diet. 4 key findings →
Design: randomized controlled trial Participants: 285 Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
This randomized trial gave hearing aids plus counseling, or only general health education, to 977 older adults with untreated hearing loss, then tracked cognition for three years. 4 key findings →
Design: RCT Participants: 977 Evidence: moderate
Full summary, score breakdown and related studies → Original source
These findings extend the evidence base for multidomain lifestyle interventions to populations historically under-represented in dementia research, supporting their feasibility and scalability as strategies to reduce cognitive decline risk amid the rapidly growing burden of dementia in low-income and middle-income countries. 3 key findings →
Design: RCT Participants: 1,065 Evidence: moderate
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African heritage diets are increasingly being replaced by Western-style dietary patterns because of urbanization, economic development, increased access to processed foods, globalization and changing social norms. 2 key findings →
Design: randomized controlled trial Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
When compared with propofol, dexmedetomidine sedation reduced incidence, delayed onset, and shortened duration of POD in elderly patients after cardiac surgery. 3 key findings →
Design: randomized controlled trial Evidence: high
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This is the first randomized trial to investigate the impact of a ketogenic diet in patients with uniform diagnoses of AD. 3 key findings →
Design: randomized controlled trial Participants: 26 Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
Scale of benefit is comparable with in-person training, indicating its potential as a public health intervention. 3 key findings →
Design: randomized controlled trial Participants: 2,912 Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
Enrolment took place between March 2023 and May 2023. 3 key findings →
Design: randomized controlled trial Participants: 4,533 Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
Ageing of the population, together with population growth, has brought along an ample increase in the number of older individuals living with dementia and disabilities. 5 key findings →
Design: randomized controlled trial Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
Pre- and postoperative orthogeriatric care given in an acute geriatric ward was not effective in reducing delirium or long-term cognitive impairment in patients with hip fracture. 5 key findings →
Design: randomized controlled trial Participants: 329 Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
APPLE-Tree is an accessible intervention associated with small improvements in cognition, although these results were not statistically significant. 1 key finding →
Design: RCT Participants: 746 Evidence: null result
Full summary, score breakdown and related studies → Original source Free full text
Although no overall EF benefit was observed, RE improved attentional/inhibitory control in cognitively normal older adults. 4 key findings →
Design: RCT Participants: 90 Evidence: null result
Full summary, score breakdown and related studies → Original source Free full text
Depressive symptoms may increase the risk of progressing from mild cognitive impairment (MCI) to dementia. 2 key findings →
Design: randomized controlled trial Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
Whether the cognitive benefits of physical exercise can improve the overall well-being of this group remains unknown. 2 key findings →
Design: randomized controlled trial Participants: 120 Evidence: high
Full summary, score breakdown and related studies → Original source Full text may need a subscription
From October 2018 to March 2020, 58 participants were recruited (29 per group, 95% [86%-99%]). 5 key findings →
Design: randomized controlled trial Participants: 58 Evidence: high
Full summary, score breakdown and related studies → Original source Free full text
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 27,780 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,780 records, built mostly from automated pulls of Europe PMC (61.1% of the library) and OpenAlex (18.3%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,034 records (3.7% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →