28,180 Alzheimer's and dementia studies in plain English, each scored out of 100.
Our study is not subject to the biases of meta-analyses of published data, and it represents an important milestone in an ongoing collaborative effort to examine the neurobiological underpinnings of PTSD and the brain's response to trauma. 2 key findings →
Design: meta-analysis Participants: 1,868 Evidence: high
Full summary, score breakdown and related studies → Original source
Relative to control subjects, patients had significantly smaller HCVs (standardized mean difference = -0.32 [95% confidence interval, -0.44 to -0.19]). 5 key findings →
Design: cohort study Participants: 2,702 Evidence: moderate
Full summary, score breakdown and related studies → Original source
The number of ECT sessions and electrode placement impacts the extent and laterality of hippocampal enlargement, but volume change is not positively associated with clinical outcome. 4 key findings →
Design: longitudinal study Participants: 281 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Although numerous studies of the longitudinal course of schizophrenia have demonstrated the clinical deterioration that occurs predominantly in the early stages of the illness, the pathophysiology of this clinical phenomenon has not been established. 5 key findings →
Design: longitudinal study Participants: 107 Evidence: moderate
Full summary, score breakdown and related studies → Original source
ECT-induced neuroplasticity in the hippocampus and amygdala relates to improved clinical response and is pronounced in regions with prominent connections to ventromedial prefrontal cortex and other limbic structures. 2 key findings →
Design: cross-sectional Participants: 43 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Smaller hippocampal volume in adolescents at high risk for depression suggests that it may be a vulnerability marker for the illness. 4 key findings →
Design: longitudinal study Evidence: moderate
Full summary, score breakdown and related studies → Original source
Future longitudinal studies with trauma control subjects and neuropsychological measures are indicated to further elucidate the relationship between hippocampus and behavioral abnormalities in young PTSD subjects. 3 key findings →
Design: longitudinal study Evidence: moderate
Full summary, score breakdown and related studies → Original source
In MDD, the packing density of glia, pyramidal neurons, and granule cell neurons is significantly increased in all hippocampal subfields and the dentate gyrus, and pyramidal neuron soma size is significantly decreased as well. 5 key findings →
Participants: 19 Evidence: low
Full summary, score breakdown and related studies → Original source
These findings suggest that long-term treatment with paroxetine is associated with improvement of verbal declarative memory deficits and an increase in hippocampal volume in PTSD. 5 key findings →
Participants: 28 Evidence: low
Full summary, score breakdown and related studies → Original source
Hippocampal involvement in MDD is confined to principal substructures only. 3 key findings →
Participants: 80 Evidence: low
Full summary, score breakdown and related studies → Original source
Our findings confirm and extend previous voxel-based morphometry analyses in ill subjects with schizophrenia. 4 key findings →
Participants: 169 Evidence: low
Full summary, score breakdown and related studies → Original source
These findings support evidence of genetic control of brain volume even in adults, particularly of hippocampal and neocortical volume and of cortical volumetric reductions being familial, but do not support measures of subcortical volumes per se as representing intermediate biologic phenotypes. 4 key findings →
Participants: 169 Evidence: low
Full summary, score breakdown and related studies → Original source
We have previously reported smaller hippocampal volume and deficits in short-term memory in patients with combat-related posttraumatic stress disorder (PTSD) relative to comparison subjects. 2 key findings →
Participants: 17 Evidence: low
Full summary, score breakdown and related studies → Original source
Medication-free nonelderly depressed outpatients without alcohol dependence or adverse experiences in childhood had normal hippocampal volume. 4 key findings →
Participants: 22 Evidence: low
Full summary, score breakdown and related studies → Original source
Changes in human HFV associated with sustained hypercortisolemia are reversible, at least in part, once cortisol levels decrease. 5 key findings →
Participants: 22 Evidence: low
Full summary, score breakdown and related studies → Original source
These findings demonstrate a disruption in fornix integrity in patients with schizophrenia. 4 key findings →
Design: cross-sectional Evidence: low
Full summary, score breakdown and related studies → Original source
This study used quantitative volumetric magnetic resonance imaging techniques to explore the neuroanatomic correlates of chronic, combat-related posttraumatic stress disorder (PTSD) in seven Vietnam veterans with PTSD compared with seven nonPTSD combat veterans and eight normal nonveterans. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The results of our study indicate no reduction in the volume of the hippocampus in patients with major depression. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Recurrent depression is associated with smaller hippocampal volume which is most prominent in the posterior hippocampus. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Patients receiving chronic corticosteroid therapy have smaller hippocampal volumes, lower N-acetyl aspartate ratios, and declarative memory deficits compared with controls. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The five-predictor combination strongly predicted conversion to AD and was markedly superior to combining age and MMSE. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
N-acetyl asparate and creatine reductions imply that there are hippocampal abnormalities in posttraumatic stress disorder. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
We confirmed previous findings of smaller hippocampal volume in PTSD in a new population made up of police officers, excluding comorbidity as a confounder. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The findings suggest that adult neurogenesis is required to maintain hippocampal volume but is not responsible for stress-induced volume loss. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
These data suggest that the overwhelming stress of maltreatment experiences in childhood is associated with adverse brain development. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 28,180 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 28,180 records, built mostly from automated pulls of Europe PMC (61.7% of the library) and OpenAlex (18.1%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,034 records (3.7% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →