30,580 Alzheimer's and dementia studies in plain English, each scored out of 100.
Since several of these disorders, such as amyotrophic lateral sclerosis, are associated with oxidative stress, and since MT is able to prevent the formation of free radicals, it is believed that cytokine-induced induction of MT provides a long-lasting protection to avert oxidative damage. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Deficiency in docosahexaenoic acid (DHA) is associated with impaired visual and neurological postnatal development, cognitive decline, macular degeneration, and other neurodegenerative diseases. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Glaucoma is an age-related optic neuropathy involving sensitivity to ocular pressure. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
String vessels are thin connective tissue strands, remnants of capillaries, with no endothelial cells; they do not carry blood flow. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
This review will discuss the formation and potential implications of 7-ketocholesterol (7KCh) in the retina. 7KCh is a proinflammatory oxysterol known to be present in high amounts in oxidized LDL deposits associated with atheromatous plaques. 7KCh is generated in situ in these lipoprotein deposits where it can accumulate and reach very high concentrations. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Cognitive impairment represents an important and often defining component of the clinical syndromes of Lewy body disorders: Parkinson's disease and dementia with Lewy bodies. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Recent progress in the field of the stem cell research has given new hopes to treat and even cure diverse degenerative disorders and incurable diseases in human. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Although traditionally regarded as spared, a range of oculomotor dysfunction has been recorded in patients with amyotrophic lateral sclerosis (ALS). 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Accumulating evidence supports a causal role of hypertension for cognitive decline above and beyond its relationship to frank stroke. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Nectins and nectin-like molecules (Necls)/Cadms are Ca(2+)-independent immunoglobulin superfamily cell adhesion molecules, expressed in most cell types. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Circadian misalignment and sleep disruption is evident in patients with MCI, and is consistent with changes observed in Alzheimer's disease. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Abnormal tau AT8, a marker of injury in various neurological diseases, is present in human glaucomas with uncontrolled intraocular pressure. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Ginkgo biloba is a dioecious tree with a history of use in traditional Chinese medicine. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Despite intense research, the pathogenesis of primary open-angle glaucoma (POAG) is still not completely understood. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Taurine is a conditionally-essential amino acid which is not utilized in protein synthesis, but rather is found free or in simple peptides. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Domoic acid (Dom), a rigid analog of the excitotoxic amino acids, glutamate and kainic acid, is believed to be the mussel neurotoxin responsible for a recent food poisoning incident in Canada that killed some people and left others with memory impairment. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
The APP-PS1ΔE9 mouse model of Alzheimer's disease (AD) exhibits age dependent amyloid β (Aβ) plaque formation in their central nervous system due to high expression of mutated human APP and PSEN1 transgenes. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Glaucoma is a long-term ocular neuropathy defined by optic disc or retinal nerve fiber structural abnormalities and visual field abnormality. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Using a well characterized in vivo rat glaucoma model, we show an age-related increase in endogenous retinal tau that was markedly exacerbated by ocular hypertension. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
The pineal secretory product melatonin has, in addition to regulating retinal, circadian and vascular functions, neuroprotective effects. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
We and others have reported heterozygous progranulin mutations as an important cause of frontotemporal lobar degeneration (FTLD). 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Our findings suggest that the presence of marked EEG slowing on spectral analysis might be indicative of the short-term development of MCI in patients initially diagnosed with IRBD. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The cellular and molecular mechanisms of phagocytic clearance of apoptotic cells and debris have been intensely studied in invertebrate model organisms and in the mammalian immune system. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Oxidative stress plays a key role in neurodegeneration of CNS neurons such as in Alzheimer disease, Parkinson's disease and glaucoma. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
This review summarizes the mechanisms and recent developments of optical coherence tomography and its practical uses in neurology. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 30,580 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 30,580 records, built mostly from automated pulls of Europe PMC (64.7% of the library) and OpenAlex (16.6%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,037 records (3.4% of the library) are not peer-reviewed — 964 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →