79/100
✓ Peer-reviewed
alzhub usefulness score 79 out of 100.
·
Neurology
·
2024-01-17
Among 91,881 participants (mean age 59.3 at baseline, 55.0% female participants), 16,507 incident ADRD cases were identified from Medicare claims (1999-2016, mean follow-up 9.3 years). 5 key findings →
Design: cohort study
Participants: 91,881
Evidence: moderate
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69/100
✓ Peer-reviewed
alzhub usefulness score 69 out of 100.
·
Neurology
·
2016-07-01
In this community-based cohort without dementia, florbetapir uptake is associated with older age and APOE genotype. 5 key findings →
Design: longitudinal study
Participants: 329
Evidence: moderate
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67/100
✓ Peer-reviewed
alzhub usefulness score 67 out of 100.
·
Neurology
·
2025-09-04
Among 13,875 individuals with nonmissing VRF and outcome data with up to 30 years of follow-up (25% Black, 54% female), 179 developed PD at a mean age of 73.4 years, 94 developed PDD at a mean age of 79.2 years, and 1,791 developed dementia without PD at a mean age of 79.7 years. 5 key findings →
Design: longitudinal study
Participants: 13,875
Evidence: moderate
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66/100
✓ Peer-reviewed
alzhub usefulness score 66 out of 100.
·
Neurology
·
2015-07-02
A large proportion of the Medicare PD population resides in an LTCF. 2 key findings →
Design: cohort study
Participants: 38,334
Evidence: moderate
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64/100
✓ Peer-reviewed
alzhub usefulness score 64 out of 100.
·
Neurology
·
2008-11-01
Factors influencing survival in Alzheimer disease include race/ethnicity and comorbid diabetes and hypertension. 5 key findings →
Design: longitudinal study
Participants: 323
Evidence: moderate
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63/100
✓ Peer-reviewed
alzhub usefulness score 63 out of 100.
·
Neurology
·
1998-05-01
We examined the neuropsychological test performance of a randomly selected community sample of English-speaking non-Hispanic African American and white elders in northern Manhattan. 3 key findings →
Evidence: low
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61/100
✓ Peer-reviewed
alzhub usefulness score 61 out of 100.
·
Neurology
·
2013-07-31
Among older adults, anemia is associated with an increased risk of developing dementia. 5 key findings →
Participants: 2,552
Evidence: low
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61/100
✓ Peer-reviewed
alzhub usefulness score 61 out of 100.
·
Neurology
·
2020-10-23
Of 9,033 ARIC participants with sufficient Medicare coverage data (4,980 [55.1%] female, 1993 [22.1%] Black), 671 met the definition of LOE. 2 key findings →
Design: cohort study
Evidence: moderate
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60/100
✓ Peer-reviewed
alzhub usefulness score 60 out of 100.
·
Neurology
·
2000-03-01
Dementia is frequent after ischemic stroke, occurring in one-fourth of the elderly patients in the authors' cohort. 3 key findings →
Participants: 453
Evidence: moderate
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60/100
✓ Peer-reviewed
alzhub usefulness score 60 out of 100.
·
Neurology
·
2016-12-30
Poorer OI in older adults without dementia was associated with increased risk of dementia. 5 key findings →
Participants: 2,428
Evidence: low
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60/100
✓ Peer-reviewed
alzhub usefulness score 60 out of 100.
·
Neurology
·
2025-09-04
The ARIC study enrolled 15,792 participants (27% Black) aged 45-64 years. 5 key findings →
Participants: 15,792
Evidence: moderate
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60/100
✓ Peer-reviewed
alzhub usefulness score 60 out of 100.
·
Neurology
·
2025-12-29
Of the 2,183 participants (mean ± SD age 79 ± 4.5 years, 58% female, 24% Black), 176 (8%) developed dementia. 5 key findings →
Design: cohort study
Participants: 2,183
Evidence: moderate
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59/100
✓ Peer-reviewed
alzhub usefulness score 59 out of 100.
·
Neurology
·
2020-07-15
Midlife CVRFs, especially hypertension, diabetes mellitus, and smoking, are common and associated with accelerated cognitive decline at midlife. 5 key findings →
Participants: 143
Evidence: low
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57/100
✓ Peer-reviewed
alzhub usefulness score 57 out of 100.
·
Neurology
·
1998-10-01
In this population, the prevalence of AD and other dementias was low, increased with age, and was not associated with gender or literacy. 5 key findings →
Participants: 5,126
Evidence: moderate
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57/100
✓ Peer-reviewed
alzhub usefulness score 57 out of 100.
·
Neurology
·
2013-12-11
Among elderly Medicare beneficiaries with PD, race, sex, and neighborhood SES are strong independent predictors of DBS receipt. 5 key findings →
Design: cohort study
Evidence: moderate
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56/100
✓ Peer-reviewed
alzhub usefulness score 56 out of 100.
·
Neurology
·
2013-11-06
This is the largest study so far documenting a delayed onset of dementia in bilingual patients and the first one to show it separately in different dementia subtypes. 3 key findings →
Participants: 648
Evidence: low
Full summary, score breakdown and related studies →
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56/100
✓ Peer-reviewed
alzhub usefulness score 56 out of 100.
·
Neurology
·
2000-03-01
Incidence rates of all dementias and of AD increased with age; men and those with lesser education had higher rates of possible/incipient dementia (CDR = 0.5) in this community. 5 key findings →
Participants: 1,298
Evidence: moderate
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54/100
✓ Peer-reviewed
alzhub usefulness score 54 out of 100.
·
Neurology
·
2004-06-01
Deterioration in Alzheimer disease appears to be driven by neuritic plaques and neurofibrillary tangles at different stages of the disease. 4 key findings →
Participants: 102
Evidence: low
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54/100
✓ Peer-reviewed
alzhub usefulness score 54 out of 100.
·
Neurology
·
1996-03-01
Previous research has shown that the Mini-Mental State Examination (MMS) is biased as a measure of cognitive impairment in minority and low-education patients. 3 key findings →
Participants: 590
Evidence: low
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53/100
✓ Peer-reviewed
alzhub usefulness score 53 out of 100.
·
Neurology
·
2025-04-11
A total of 5,129 participants were included in the study (59% female; 22% identified as Black; mean (standard deviation) age at visit 5 of 75 (5) years). 5 key findings →
Participants: 1,026
Evidence: low
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52/100
✓ Peer-reviewed
alzhub usefulness score 52 out of 100.
·
Neurology
·
1994-01-01
We surveyed 1,545 subjects--recruited into the UK Medical Research Council elderly hypertension treatment trial between 1982 and 1987--to detect incident cases of dementia, identifying 50 cases of dementia, including 31 cases of probable or possible Alzheimer's disease (AD). 2 key findings →
Participants: 1,545
Evidence: low
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Original source
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52/100
✓ Peer-reviewed
alzhub usefulness score 52 out of 100.
·
Neurology
·
2001-01-09
The incidence rate for AD was significantly higher among African-American and Caribbean Hispanic elderly individuals compared white individuals.
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51/100
✓ Peer-reviewed
alzhub usefulness score 51 out of 100.
·
Neurology
·
1990-04-01
The purpose of this study was to investigate the prevalence of dementia in an Italian population using a door-to-door 2-phase design. 2 key findings →
Participants: 778
Evidence: low
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51/100
✓ Peer-reviewed
alzhub usefulness score 51 out of 100.
·
Neurology
·
2017-11-08
Goal 1 of the National Plan to Address Alzheimer's Disease is to prevent and effectively treat Alzheimer disease and Alzheimer disease-related dementias by 2025. 3 key findings →
Evidence: low
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Original source
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51/100
✓ Peer-reviewed
alzhub usefulness score 51 out of 100.
·
Neurology
·
2014-07-30
The National Alzheimer's Project Act, signed into law in 2011, mandates a National Plan to Address Alzheimer's Disease that is updated annually. 5 key findings →
Evidence: low
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How the 0–100 score works — and why some entries are capped
This is alzhub's own score. It is not an official metric, not an impact factor,
and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a
scientist can tell a landmark trial from a conference abstract without having to already know the
difference. Every point comes from one of 20 components, all of them printed on the study itself,
so you can disagree with our arithmetic rather than having to trust the total.
- Journal tier up to 10 pts
- Journal's citation record up to 4 pts
- Study design up to 12 pts
- Strength of evidence up to 5 pts
- Peer-review validation up to 10 pts
- How recent up to 5 pts
- Sample size up to 4 pts
- Effect reported up to 3 pts
- Studied in people up to 3 pts
- Randomised / blinded up to 2 pts
- Times cited up to 7 pts
- Citations per year up to 5 pts
- Impact for its field and year up to 6 pts
- Cited by studies here up to 6 pts
- Still being cited up to 4 pts
- Senior author's track record up to 4 pts
- Institution's track record up to 3 pts
- Multi-centre collaboration up to 3 pts
- Indexed in PubMed up to 2 pts
- Free to read up to 2 pts
Journals are placed in ordered tiers, never given a numeric impact factor — we
could not verify current impact factors from a source we control, and an invented one would be
worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science,
Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed
journal. A separate part scores how much the journal's own papers are cited, which tells the
tier-3 journals apart.
Two rules we don't bend. First, we never fill in a
missing value: if a record does not state a sample size or a design, that component scores
zero, and if we simply have no data for a part, such as a citation count, that part is left out and
the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed
article is capped at 16/100 and carries a warning chip — so a conference abstract or
a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not
work — above an early positive finding. Someone deciding whether to buy a supplement is served by
that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is
reproducible: the same file always yields the same numbers.
See the whole rubric drawn out →
— four charts covering all 27,380 studies: how the scores are spread and where the cap
bites, which of the 20 components the library is strong and weak on, which subjects rest on
stronger evidence, and what kinds of study each subject is actually built from.