27,380 Alzheimer's and dementia studies in plain English, each scored out of 100.
Physical exercise is a cornerstone in the management of many neurodegenerative disorders, such as Parkinson's disease, dementia, and stroke. 1 key finding →
Design: narrative review Evidence: low
Full summary, score breakdown and related studies → Original source
Chronic cerebral hypoperfusion (CCH) is a common consequence of various cerebral vascular disorders and hemodynamic and blood changes. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
It has been suggested that microglia, a type of glial cells in the central nervous system, play various important roles in normal and pathologic brains. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
A sequential light and electron microscopic study of cerebral cortex was performed in a rat model of portal-systemic encephalopathy produced by creating a portacaval shunt and followed by ammoniate resin feedings. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
The role of inflammation in neurological disorders is increasingly recognised. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Latent reservoirs of human immunodeficiency virus (HIV) present significant challenges for eradicating HIV from infected persons, particularly reservoirs in the brain established during acute infection. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
A host of diabetes-related insults to the central nervous system (CNS) have been clearly documented in type-1 and -2 diabetic patients as well as experimental animal models. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Dephosphorylation (activation) of cofilin, an actin binding protein, is stimulated by initiators of neuronal dysfunction and degeneration including oxidative stress, excitotoxic glutamate, ischemia, and soluble forms of beta-amyloid peptide (Abeta). 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The most important new development during recent years in the field of degenerative dementia concerns synaptic pathology. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The clinical manifestations that occur after traumatic brain injury (TBI) include a wide range of cognitive, emotional, and behavioral deficits. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The blood-brain barrier (BBB) not only impedes the influx of intravascular substances from blood to brain, but also promotes transport of substances from blood to brain or from brain to blood through several transport systems such as carrier-mediated transport, active efflux transport, and receptor-mediated transport systems. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Delirium is a profound, acute confusional state that leads to long-term cognitive decline. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
These preliminary study results show an association between human brain activity of microglia, astrocytes, and IL-6 and delirium in elderly patients and add to the accumulating evidence that inflammatory mechanisms are involved in delirium. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
A large percentage of patients subjected to general anesthesia at 65 years and older exhibit postoperative delirium (POD). 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Normal brain function is facilitated by a highly organized and interconnected structure allowing complex integration of sensory information and motor responses. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Hypertension, a powerful risk factor for stroke and dementia, has damaging effects on the brain and its vessels. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Iron has a role in brain injury after IVH. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Diffusion tensor imaging (DTI) has become one of the most popular MRI techniques in brain research, as well as in clinical practice. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Age has a powerful effect on enhanced susceptibility to neurodegenerative diseases, including susceptibility to stroke and cognitive impairment (CI) even in optimally healthy individuals. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Several clinical trials have evaluated the potential of antiglutamate drugs to improve outcome following acute ischaemic stroke, but to date, the results of these have been disappointing. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Higher age, female sex, cigarette smoking, elevated blood pressure, and baseline lesion load were associated with small vessel disease progression. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Proof that blood-brain barrier failure is key to these conditions could provide a target for new treatments to reduce the effects of vascular disease on the brain and prevent cognitive decline and dementia. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Mutations in Notch3 cause CADASIL (cerebral autosomal dominant adult onset arteriopathy), which leads to stroke and dementia in humans. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The review focuses on the clinical diagnostic utility of transcranial magnetic stimulation (TMS). 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Arterial spin labeling (ASL) is a magnetic resonance (MR) imaging technique used to assess cerebral blood flow noninvasively by magnetically labeling inflowing blood. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
10 of the 902 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 27,380 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,380 records, built mostly from automated pulls of Europe PMC (60.6% of the library) and OpenAlex (18.6%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,032 records (3.8% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →