Our study is a unique resource of neuroimaging and cognitive measures relevant to change across the adult lifespan. 3 key findings →
Participants: 3,000 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Research
27,780 Alzheimer's and dementia studies in plain English, each scored out of 100.
The pattern of deficits across tasks was qualitatively compared with normal age-related decline, and early-stage dementia. 3 key findings →
Participants: 460 Evidence: low
Full summary, score breakdown and related studies → Original source
Baseline depression and low cognitive reserve significantly increased the risk of subsequent dementia at follow-up. 5 key findings →
Participants: 2,099 Evidence: low
Full summary, score breakdown and related studies → Original source
The paper aimed to compare how factors previously identified as predictive factors for cognitive decline and dementia related to cognitive performance on the one hand and brain health on the other. 5 key findings →
Participants: 1,707 Evidence: low
Full summary, score breakdown and related studies → Original source
Education partially mediated the effect of adolescent cognition on CI in the cognitive assessment aample and AD8 in the questionnaire sample (Ps < 0.001). 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Cognitive reserve and frailty are factors associated with Alzheimer's disease and related dementias (ADRD). 5 key findings →
Participants: 908 Evidence: low
Full summary, score breakdown and related studies → Original source
166 patients were consecutively enrolled (mean age was 85.7 years old, females composed 68%); 25% had a diagnosis of amnestic mild cognitive impairment, and 75% had a diagnosis of dementia. 5 key findings →
Participants: 166 Evidence: low
Full summary, score breakdown and related studies → Original source
Higher NIH Toolbox Friendship scores predicted less episodic memory decline. 5 key findings →
Design: cross-sectional Evidence: moderate
Full summary, score breakdown and related studies → Original source
We found that the bilingual patients had been diagnosed 4.3 years later and had reported the onset of symptoms 5.1 years later than the monolingual patients. 5 key findings →
Participants: 102 Evidence: low
Full summary, score breakdown and related studies → Original source
Patients in medical and surgical ICUs are at high risk for long-term cognitive impairment. 4 key findings →
Participants: 821 Evidence: low
Full summary, score breakdown and related studies → Original source
Middle-aged adults at risk of dementia show evidence of poorer cognitive performance, principally in visuospatial functions. 1 key finding →
Participants: 210 Evidence: low
Full summary, score breakdown and related studies → Original source
Amyloid deposition is associated with lower cognitive performance both in AD patients and in the normal elderly, but the association is modified by CR, suggesting that CR may be protective against amyloid-related cognitive impairment. 4 key findings →
Participants: 17 Evidence: low
Full summary, score breakdown and related studies → Original source
50/100
Given the uncertain relationship between objective and subjective memory complaints (SMC), we conducted a study of cognitive function in older people with memory complaints in a large population-based elderly Spanish cohort (NEDICES). 3 key findings →
Participants: 1,073 Evidence: moderate
Full summary, score breakdown and related studies → Original source
This work suggests that academic and community factors beyond years of education have a marked impact on late-life cognition. 5 key findings →
Participants: 130 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Associations between epigenetic AA and cognitive performance over-time varied by sex. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
We investigated self-rating of cognitive task performance (self-appraisal) and the difference between self-rating and actual task performance (appraisal discrepancy) in cognitively healthy older adults and their relationship with cortical thickness and Alzheimer's disease (AD) biomarkers, amyloid and tau. 4 key findings →
Participants: 151 Evidence: low
Full summary, score breakdown and related studies → Original source
To assess the validity of Yaakov Stern's theory, which postulates that the first cognitive deficits of Alzheimer disease are delayed in patients with high cognitive reserve, compared to those with low cognitive reserve, but this is subsequently associated with faster cognitive decline when cerebral lesions have reached a certain degree of severity. 3 key findings →
Participants: 318 Evidence: low
Full summary, score breakdown and related studies → Original source
The Cognitive Reserve hypothesis suggests that there are individual differences in the ability to cope with the pathologic changes in Alzheimer's Disease. 3 key findings →
Participants: 125 Evidence: low
Full summary, score breakdown and related studies → Original source
To appraise the validity of the Yaakov Stern's theory, which postulates that the first cognitive deficits of Alzheimer's disease are delayed in patients with high cognitive reserve, compared to those with low cognitive reserve, but is subsequently associated with faster cognitive decline when cerebral lesions have reached some degree of severity. 3 key findings →
Participants: 318 Evidence: low
Full summary, score breakdown and related studies → Original source
No significant association was found between social isolation and ToM abilities for both the unadjusted and adjusted models. 3 key findings →
Participants: 83 Evidence: low
Full summary, score breakdown and related studies → Original source
Presentation age was similar between groups (median 74-75 years). 5 key findings →
Participants: 1,782 Evidence: low
Full summary, score breakdown and related studies → Original source
There were ethnic/race group differences in MoCA scores but no relationships with chronic knee pain stage. 5 key findings →
Participants: 147 Evidence: low
Full summary, score breakdown and related studies → Original source
The OCS-Plus represents a major methodological advance in dementia studies in LMICs, and enhances understanding of cognitive aging. 1 key finding →
Design: cross-sectional Evidence: moderate
Full summary, score breakdown and related studies → Original source
48/100
In this study, the authors evaluated whether the association between low educational level and increased risk of Alzheimer's disease (AD) and dementia may be explained by occupation-based socioeconomic status (SES). 5 key findings →
Participants: 101 Evidence: moderate
Full summary, score breakdown and related studies → Original source
Growing epidemiological evidence suggests that premorbid participation in cognitive leisure activities (CLA) reduces the risk of dementia by increasing cognitive reserve. 3 key findings →
Participants: 500 Evidence: moderate
Full summary, score breakdown and related studies → Original source
From across this tag
9 of the 208 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.
- Musical Activity During Life Is Associated With Multi-Domain Cognitive and Brain Benefits in Older Adults
- Social participation diversity and cognitive trajectories in older adults with hypertension and diabetes: a longitudinal cohort study
- Bilingualism and Cognitive Aging in Ethnically Diverse Older Adults: Cross-sectional and Longitudinal Evidence from HABS-HD
- Bilingualism: Pathway to Cognitive Reserve
- Causal association of cognitive reserve on Alzheimer's disease with putative sex difference
- Peruvian validation and standardization of the TabCAT-brain health assessment
- Cohort Profile Update: The Lothian Birth Cohorts of 1921 and 1936
- Version 3 of the Alzheimer Disease Centers' Neuropsychological Test Battery in the Uniform Data Set (UDS)
- Functional ability is associated with higher adherence to behavioral interventions in mild cognitive impairment
Where “Free full text” comes from
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
How the 0–100 score works — and why some entries are capped
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
- Journal tier up to 10 pts
- Journal's citation record up to 4 pts
- Study design up to 12 pts
- Strength of evidence up to 5 pts
- Peer-review validation up to 10 pts
- How recent up to 5 pts
- Sample size up to 4 pts
- Effect reported up to 3 pts
- Studied in people up to 3 pts
- Randomised / blinded up to 2 pts
- Times cited up to 7 pts
- Citations per year up to 5 pts
- Impact for its field and year up to 6 pts
- Cited by studies here up to 6 pts
- Still being cited up to 4 pts
- Senior author's track record up to 4 pts
- Institution's track record up to 3 pts
- Multi-centre collaboration up to 3 pts
- Indexed in PubMed up to 2 pts
- Free to read up to 2 pts
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 27,780 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
What this library is — and isn't
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,780 records, built mostly from automated pulls of Europe PMC (61.1% of the library) and OpenAlex (18.3%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,034 records (3.7% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →