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Research

27,380 Alzheimer's and dementia studies in plain English, each scored out of 100.

Find studies

Showing 9,601–9,625 of 10,985 studies · free to read (page 385 of 440) · 27,380 in the whole library · How the 0–100 score works

Browse by subject, author or institution

Each number is how many studies that link shows, with your other filters kept.

Subjects

Authors

Names as each record prints them; the same person can appear under two spellings.

Institutions

From OpenAlex; 12,859 studies have no institution on record and are not counted here.

A note on reading research. One study is rarely the final word.

We try to note the size of a study, whether it was in humans or animals, and how early-stage the finding is. If a summary here doesn't make that clear, treat it with extra caution and check the original source.

An additional human chromosome 21 causes suppression of neural fate of pluripotent mouse embryonic stem cells in a teratoma model

✓ Peer-reviewed alzhub usefulness score 37 out of 100. BMC developmental biology 2007-11-29

We demonstrate that a supernumerary chromosome 21 causes Inhibition of Neuroectodermal DIfferentiation (INDI) of pluripotent ES cells. 3 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Metformin effectively alleviates the symptoms of Alzheimer in rats by lowering amyloid β deposition and enhancing the insulin signal

✓ Peer-reviewed alzhub usefulness score 37 out of 100. Metabolic brain disease 2024-11-25

Alzheimer's disease (AD) exhibits distinct biochemical and histopathological attributes, encompassing cellular, neuronal, and oxidative impairment. 5 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Outcome measures in clinical trials on medicinal products for the treatment of dementia: a European regulatory perspective

✓ Peer-reviewed alzhub usefulness score 37 out of 100. International psychogeriatrics 2007-04-16

Based on efficacy and safety data, several drugs have been approved for symptomatic improvement of dementia of the Alzheimer type and one for the symptomatic improvement of dementia associated with Parkinson's disease. 4 key findings →

Evidence: high

Full summary, score breakdown and related studies → Original source Free full text

Intervention for a Digital, Cognitive, Multi-Domain Alzheimer Risk Velocity Study: Protocol for a Randomized Controlled Trial

✓ Peer-reviewed alzhub usefulness score 37 out of 100. JMIR research protocols 2022-02-04

The intervention in the Digital, Cognitive, Multi-domain Alzheimer Risk Velocity is uniquely designed to reduce the risk of AD through a web-based health coaching experience that addresses the modifiable lifestyle-based risk factors. 3 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Cognition, language, and clinical pathological features of non-Alzheimer's dementias: an overview

✓ Peer-reviewed alzhub usefulness score 37 out of 100. Journal of communication disorders 2010-05-06

The value and durability of this potential contribution, however, demands an improved discipline-wide knowledge base about the unique features associated with different dementia variants. 1 key finding →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome

✓ Peer-reviewed alzhub usefulness score 37 out of 100. Current Alzheimer research 2016-01-01

Down syndrome (DS) is the most common non-lethal genetic condition that affects approximately 1 in 700 births in the United States of America. 1 key finding →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

The amyloid percursor protein of Alzheimer disease is expressed as a 130 kDa polypeptide in various cultured cell types

✓ Peer-reviewed alzhub usefulness score 37 out of 100. FEBS letters 1988-12-01

The vascular and parenchymal amyloid deposits in Alzheimer disease (AD), normal aging and Down syndrome are mainly composed of a 4 kDa polypeptide (A4), which derives from a larger precursor protein (APP). 2 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Genome-wide expression analysis of cultured trophoblast with trisomy 21 karyotype

✓ Peer-reviewed alzhub usefulness score 37 out of 100. Human reproduction (Oxford, England) 2007-07-17

Our results demonstrate that gene expression in trisomy 21 affected placentas significantly differs from that of chromosomally normal placentas, and this difference is only partially explained by over-expression of genes from chromosome 21. 5 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

LIM homeobox 8 (Lhx8) is a key regulator of the cholinergic neuronal function via a tropomyosin receptor kinase A (TrkA)-mediated positive feedback loop

✓ Peer-reviewed alzhub usefulness score 37 out of 100. The Journal of biological chemistry 2013-11-21

Basal forebrain cholinergic neurons play an important role in cognitive functions such as learning and memory, and they are affected in several neurodegenerative diseases, including Alzheimer disease and Down syndrome. 1 key finding →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Transcriptome and metabolome analysis of crGART, a novel cell model of de novo purine synthesis deficiency: Alterations in CD36 expression and activity

✓ Peer-reviewed alzhub usefulness score 37 out of 100. PloS one 2021-07-20

In humans, GART [phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) / phosphoribosylglycinamide synthetase (EC 6.3.4.13) / phosphoribosylaminoimidazole synthetase (EC 6.3.3.1)] is a trifunctional protein which catalyzes the second, third, and fifth reactions of the ten step de novo purine synthesis (DNPS) pathway. 3 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Tau proteins in the temporal and frontal cortices in patients with vascular dementia

✓ Peer-reviewed alzhub usefulness score 37 out of 100. Journal of neuropathology and experimental neurology 2015-02-01

We previously reported that, in the brains of older patients with vascular dementia (VaD), there is a distinctive accumulation of detergent-extractable soluble amyloid-β, with a predominance of Aβ42 species. 4 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Cerebrospinal Fluid Markers of Synaptic Injury and Functional Connectivity in Alzheimer Disease: Protocol for a Cross-Sectional Study

✓ Peer-reviewed alzhub usefulness score 37 out of 100. JMIR research protocols 2019-07-17

Synaptic loss is the best surrogate for cognitive decline in Alzheimer disease (AD) and is more closely associated with cognitive function than amyloid or tau pathologies. 4 key findings →

Design: cross-sectional Participants: 20 Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

4430 Coffee Shops and Fast-food Restaurants: Potential Neighborhood Resources for Cognitive Health and Wellbeing Among Aging Americans

✓ Peer-reviewed alzhub usefulness score 37 out of 100. Journal of Clinical and Translational Science 2020-06-01

OF IMPACT: The results contribute new evidence towards an emerging ecological model of cognitive health. 5 key findings →

Participants: 16,404 Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Applying the Relational Job Design Theory to the Retail Industry: The Association between Perceived Social Impact and Job Satisfaction, Turnover Intention, and Persistence

✓ Peer-reviewed alzhub usefulness score 37 out of 100. Health & Social Care in the Community 2024-01-01

Retail workers contribute to the daily wellbeing of customers, including those living with disabilities or diseases. 2 key findings →

Participants: 145 Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

In-hospital dementia-related deaths following implementation of the national dementia plan: observational study of national death certificates from 1996 to 2016

✓ Peer-reviewed alzhub usefulness score 37 out of 100. BMJ Open 2018-12-01

The annual number of deaths at hospital was consistently increased over time from 1996 to 2016 (age-adjusted OR: 6.01; 95% CI 5.81 to 6.21 versus home deaths). 4 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Burden of illness among patients with dementia-related psychosis

✓ Peer-reviewed alzhub usefulness score 37 out of 100. Journal of Managed Care & Specialty Pharmacy 2021-02-27

A significantly higher percentage of DRP patients had ≥1 diagnosis for behavioral health conditions in the pre-index period compared with dementia-only patients (depression: 32.4% vs. 22.8%; anxiety: 19.1% vs. 11.5%; and insomnia: 9.0% vs. 6.3%; P < 0.001 for all comparisons). 5 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

Do Medicare Beneficiaries Under Accountable Care or Medicare Advantage Use Lower Quality Nursing Homes?

✓ Peer-reviewed alzhub usefulness score 37 out of 100. Journal of the American Geriatrics Society 2024-12-31

Among SNF admissions from 2013 to 2018, the share of ACO-attributed beneficiaries increased from 7.6% to 20.2%, MA enrollees increased from 25.2% to 32.8%, and non-ACO-attributed TM enrollees decreased from 67.2% to 47.3%. 4 key findings →

Evidence: low

Full summary, score breakdown and related studies → Original source Free full text

↑ Change the filters

Where “Free full text” comes from

Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled.

How the 0–100 score works — and why some entries are capped

This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.

  • Journal tier up to 10 pts
  • Journal's citation record up to 4 pts
  • Study design up to 12 pts
  • Strength of evidence up to 5 pts
  • Peer-review validation up to 10 pts
  • How recent up to 5 pts
  • Sample size up to 4 pts
  • Effect reported up to 3 pts
  • Studied in people up to 3 pts
  • Randomised / blinded up to 2 pts
  • Times cited up to 7 pts
  • Citations per year up to 5 pts
  • Impact for its field and year up to 6 pts
  • Cited by studies here up to 6 pts
  • Still being cited up to 4 pts
  • Senior author's track record up to 4 pts
  • Institution's track record up to 3 pts
  • Multi-centre collaboration up to 3 pts
  • Indexed in PubMed up to 2 pts
  • Free to read up to 2 pts

Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.

Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.

We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.

The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.

See the whole rubric drawn out → — four charts covering all 27,380 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.

What this library is — and isn't

This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 27,380 records, built mostly from automated pulls of Europe PMC (60.6% of the library) and OpenAlex (18.6%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.

1,032 records (3.8% of the library) are not peer-reviewed — 962 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.

See the full, machine-readable breakdown of this library's coverage →

Newest studies, as a dated timeline →    Atom feed