Delirium affects 60 to 80% of ventilated patients and is associated with worse clinical outcomes including death. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Research
28,980 Alzheimer's and dementia studies in plain English, each scored out of 100.
Benzodiazepine (BZD) inappropriate use (i.e., misuse and overuse) is a worldwide public health problem. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Normal brain function is facilitated by a highly organized and interconnected structure allowing complex integration of sensory information and motor responses. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Energy intake is reduced in older individuals, with several lines of evidence suggesting that both physiological impairment of food intake regulation and non-physiological mechanisms are important. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Most decline occurred prior to hospitalization and was associated with common indicators of poor outcomes in hospitalized elders. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Hypertension, a powerful risk factor for stroke and dementia, has damaging effects on the brain and its vessels. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Application of predetermined quality criteria for prevalence and outcome studies. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
The 21 conditions selected as targets for quality improvement among vulnerable older adults include (in rank order): pharmacologic management; depression; dementia; heart failure; stroke (and atrial fibrillation); hospitalization and surgery; falls and mobility disorders; diabetes mellitus; end-of-life care; ischemic heart disease; hypertension; pressure ulcers; osteoporosis; urinary incontinence; pain management; preventive services; hearing impairment; pneumonia and influenza; vision impairment; malnutrition; and osteoarthritis. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
The caregiving stressor is associated with considerable psychological vulnerability, sleep disorders, and risk of alterations in the cardiovascular system, which seem to be modulated by caregiving characteristics. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Childhood trauma is a potent risk factor for developing depression in adulthood, particularly in response to additional stress. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Chronic pain patients exhibit increased anxiety, depression, and deficits in learning and memory. 4 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The prefrontal cortex (PFC) regulates emotional responses, but it is unclear how PFC integrates diverse inputs to select the appropriate response. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
36/100
These results suggest that the medial temporal lobe may be the first brain site affected by type 2 diabetes and that individuals in poorer metabolic control may be affected to a greater extent. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Daily restraint for 3 weeks was shown to atrophy dendrites of hippocampal pyramidal neurons in rats. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Obstructive sleep apnea syndrome (OSAS) is a common disorder with far-reaching health implications. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
From clinical studies it is known that recurrent depressive episodes associate with a reduced hippocampal volume. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Acute stress suppresses new cell birth in the hippocampus in several species. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
36/100
Chronic stress in non-human animals decreases the volume of the hippocampus, a brain region that supports learning and memory and that regulates neuroendocrine activity. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Epilepsy is a common outcome of traumatic brain injury (TBI), but the mechanisms of posttraumatic epileptogenesis are poorly understood. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Cognitive deficits and hippocampal atrophy, features that are shared with aging and dementia, have been described in type 2 diabetes mellitus (T2DM). 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Most biological findings in posttraumatic stress disorder (PTSD) are compatible with those of the chronic stress response, such as increased corticotropin-releasing factor (CRF) concentrations, catecholamine depletion within the central nervous system, and reduced hippocampal volume. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
In the dentate gyrus of the hippocampus, cell birth and maturation into neurons, or neurogenesis, occur throughout the lifetime of animals and humans. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
This study demonstrates that the impact of the BDNF Val66Met polymorphism is not confined to the hippocampus but also extends to the parahippocampal gyrus and the amygdala. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Epidemiological data suggest that omega-3 polyunsaturated fatty acids (PUFA) consumption may be inversely correlated to the prevalence and severity of depression but little is known about the underlying mechanisms. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The concept of cognitive insight was introduced in 2004 to describe the capacity of patients with psychosis to distance themselves from their psychotic experiences, reflect on them, and respond to corrective feedback. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
From across this tag
10 of the 3,795 studies in this tag that have a study page, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Health and Aging Brain Study–Health Disparities (HABS‐HD) methods and partner characteristics
- Cadmium Exposure and Incidence of All-Cause Dementia and Alzheimer’s Disease in US Adults
- Midlife cardiovascular fitness and dementia: A 44-year longitudinal population study in women
- Transition to long term care for elders with dementia
- Incidence of dementia after ischemic stroke: results of a longitudinal study
- Air pollution, a rising environmental risk factor for cognition, neuroinflammation and neurodegeneration: The clinical impact on children and beyond
- Leisure-time physical activity at midlife and the risk of dementia and Alzheimer's disease
- Cigarette smoking accelerated brain aging and induced pre-Alzheimer-like neuropathology in rats
- Population intervention models of racial ethnic disparities in cognitive outcomes from cardiometabolic risk factors – HABS-HD
- Living well with dementia: a systematic review and correlational meta-analysis of factors associated with quality of life, well-being and life satisfaction in people with dementia
Where “Free full text” comes from
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
How the 0–100 score works — and why some entries are capped
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
- Journal tier up to 10 pts
- Journal's citation record up to 4 pts
- Study design up to 12 pts
- Strength of evidence up to 5 pts
- Peer-review validation up to 10 pts
- How recent up to 5 pts
- Sample size up to 4 pts
- Effect reported up to 3 pts
- Studied in people up to 3 pts
- Randomised / blinded up to 2 pts
- Times cited up to 7 pts
- Citations per year up to 5 pts
- Impact for its field and year up to 6 pts
- Cited by studies here up to 6 pts
- Still being cited up to 4 pts
- Senior author's track record up to 4 pts
- Institution's track record up to 3 pts
- Multi-centre collaboration up to 3 pts
- Indexed in PubMed up to 2 pts
- Free to read up to 2 pts
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 28,980 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
What this library is — and isn't
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 28,980 records, built mostly from automated pulls of Europe PMC (62.8% of the library) and OpenAlex (17.6%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,038 records (3.6% of the library) are not peer-reviewed — 966 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →