Women have increased risks for both sleep disturbances and disorders and for mental health issues throughout their lives, starting in adolescence. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Research
29,380 Alzheimer's and dementia studies in plain English, each scored out of 100.
A growing number of studies in animal models have highlighted the link between sleep disorders and Alzheimer's disease (AD). 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Our aim was to determine whether the genetic liability to sleep and pain-related traits have a causal effect on risk of neurodegeneration in individuals of predominantly European ancestry. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Sleep plays an important role in homeostasis, brain plasticity, clearance of neurotoxins, cognition, memory, concentration, performance, and the regulation of the temperature, endocrine and immunological systems. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
41/100
Although poor sleep quality and extreme sleep durations have been associated with brain atrophy and dementia, it is unclear whether sleep disturbances contribute to neural injury in the absence of neurodegeneration and cognitive impairment. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Short sleep duration has been linked to the development of neurocognitive disorders. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
This cycle is challenging to study, as its bidirectional nature renders cause difficult to disentangle from effect. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The global north is facing an unprecedented rise in the prevalence of neurodegenerative diseases. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Sleep disorders are common in patients with Alzheimer's disease, and can even occur in patients with amnestic mild cognitive impairment, which appears before Alzheimer's disease. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
The aim of this review is to summarize the current evidence on the relationship between sleep and cognition and present available data reporting the impact that sleep alterations may have on cognitive functions. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Alzheimer's disease (AD) is a progressive neurodegenerative disease, characterized by memory loss and multiple cognitive impairments. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
MetS and cognitive decline share common cardiometabolic pathways as MetS components can trigger cognitive impairment. 5 key findings →
Design: narrative review Evidence: low
Full summary, score breakdown and related studies → Original source
The human lifespan has expanded drastically in the last few centuries, due to improvements in sanitation, medicine, and nutrition, but with this increase in longevity comes higher rates of cognitive pathology such as mild cognitive impairment (MCI) and dementia; the latter is estimated to reach more than 75 million people by 2030. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Physical Activity and Mental Health in the Elderly Abstract. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Alzheimer's Disease (AD) is the leading cause of dementia, observed at a higher incidence in women compared with men. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Loneliness imposes significant risks to physical, mental and brain health in older adulthood. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
This review describes associations between dementia and loneliness on the neurobiological and epidemiological levels according to the recent body of literature. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
This article provides a current review of the literature examining caffeine use in older adults. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Coupled with aging, chronic stress experienced by dementia caregivers often leads to deteriorating health. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Nursing leaders have a responsibility to promote and facilitate social engagement and connectedness to mitigate social isolation in long-term care (LTC). 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
World is greying as the proportion of the ageing population increases and the demography is changing both in the developing and developed world. 1 key finding →
Evidence: low
Full summary, score breakdown and related studies → Original source
Social concepts such as loneliness and social isolation are fairly new factors that have been recently gaining attention as to their involvement in changes in cognitive function and association with dementia. 1 key finding →
Design: narrative review Evidence: low
Full summary, score breakdown and related studies → Original source
41/100
The current review has the ultimate scope to accurately define social isolation and loneliness while highlighting the serious repercussions on health and behavior. 5 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
Older adults are at an increased risk of loneliness. 3 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
41/100
Alzheimer's disease is a progressive brain disease that is becoming a major health problem in today's world due to the aging population. 2 key findings →
Evidence: low
Full summary, score breakdown and related studies → Original source
From across this tag
10 of the 1,962 studies in this tag that have a study page, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Contribution of alcohol use disorders to the burden of dementia in France 2008-13: a nationwide retrospective cohort study
- Positive effects of combined cognitive and physical exercise training on cognitive function in older adults with mild cognitive impairment or dementia: A meta-analysis
- Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life
- Mediterranean Diet, Polyphenols, and Neuroprotection: Mechanistic Insights into Resveratrol and Oleuropein
- Association between the Mediterranean diet and cognitive decline in a biracial population
- The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans
- Activating Developmental Reserve Capacity Via Cognitive Training or Non-invasive Brain Stimulation: Potentials for Promoting Fronto-Parietal and Hippocampal-Striatal Network Functions in Old Age
- Transcranial Color-Coded Doppler Cerebral Hemodynamics Following Aerobic Exercise Training: Outcomes From a Pilot Randomized Clinical Trial
- Associations of family history of hypertension, genetic, and lifestyle risks with incident hypertension
- Microbiota-gut-brain axis and ketogenic diet: how close are we to tackling epilepsy?
Where “Free full text” comes from
Free full text links and the Full text may need a subscription label come from Unpaywall, Europe PMC and OpenAlex records of free copies, checked 10 Oct 2026. A study with neither is unknown, not paywalled. Show only studies that are free to read
How the 0–100 score works — and why some entries are capped
This is alzhub's own score. It is not an official metric, not an impact factor, and no journal, publisher or ranking body endorses it. We built it so that a reader who is not a scientist can tell a landmark trial from a conference abstract without having to already know the difference. Every point comes from one of 20 components, all of them printed on the study itself, so you can disagree with our arithmetic rather than having to trust the total.
- Journal tier up to 10 pts
- Journal's citation record up to 4 pts
- Study design up to 12 pts
- Strength of evidence up to 5 pts
- Peer-review validation up to 10 pts
- How recent up to 5 pts
- Sample size up to 4 pts
- Effect reported up to 3 pts
- Studied in people up to 3 pts
- Randomised / blinded up to 2 pts
- Times cited up to 7 pts
- Citations per year up to 5 pts
- Impact for its field and year up to 6 pts
- Cited by studies here up to 6 pts
- Still being cited up to 4 pts
- Senior author's track record up to 4 pts
- Institution's track record up to 3 pts
- Multi-centre collaboration up to 3 pts
- Indexed in PubMed up to 2 pts
- Free to read up to 2 pts
Journals are placed in ordered tiers, never given a numeric impact factor — we could not verify current impact factors from a source we control, and an invented one would be worse than none. Tier 1 is the top-tier general journals (NEJM, The Lancet, JAMA, Nature, Science, Nature Medicine); tier 2 is the leading specialty journals; tier 3 is every other peer-reviewed journal. A separate part scores how much the journal's own papers are cited, which tells the tier-3 journals apart.
Two rules we don't bend. First, we never fill in a missing value: if a record does not state a sample size or a design, that component scores zero, and if we simply have no data for a part, such as a citation count, that part is left out and the study is scored on the parts we could check. The study card says which. Second, anything that is not a peer-reviewed article is capped at 16/100 and carries a warning chip — so a conference abstract or a company press release can never outrank a peer-reviewed paper, no matter how good it looks.
We rank a rigorous null result — a good trial showing that something does not work — above an early positive finding. Someone deciding whether to buy a supplement is served by that, and the rigour is already counted by the design and journal components.
The score is computed from the published data alone and is reproducible: the same file always yields the same numbers.
See the whole rubric drawn out → — four charts covering all 29,380 studies: how the scores are spread and where the cap bites, which of the 20 components the library is strong and weak on, which subjects rest on stronger evidence, and what kinds of study each subject is actually built from.
What this library is — and isn't
This is a large sample of the Alzheimer's literature, not an exhaustive index of it. It holds 29,380 records, built mostly from automated pulls of Europe PMC (63.3% of the library) and OpenAlex (17.3%), plus smaller pulls from PubMed, Crossref and medRxiv. If a study, a drug, or a finding isn't here, that is not evidence it doesn't exist in the literature — it may simply not have been pulled in yet.
1,037 records (3.5% of the library) are not peer-reviewed — 964 of those are preprints posted before any journal review, and the rest are conference abstracts, regulatory notices and reports. Every study card on this page states its status plainly, and the score above is capped for anything that isn't a peer-reviewed article.
See the full, machine-readable breakdown of this library's coverage →