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vaccine
4 studies tagged vaccine, dated 2014-02-20 to 2026-07-22. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- A randomized, placebo-controlled, double blind Phase 1 trial of the Aβ vaccine, AV-1959R, in non-cognitively impaired participants: prelude for secondary preventive therapy in preclinical AD 2026-07-22
- Safety, tolerability and immunogenicity of vaccine ALZ-101 in patients with early Alzheimer's disease: randomised, controlled trial 2026-05-19
- A retrospective analysis of the Alzheimer's disease vaccine progress - The critical need for new development strategies 2016-04-06
Studies
4 studies carry this tag.
Date range
2014 to 2026
Top journals
- Alzheimer's & dementia : the journal of the Alzheimer's Association 1
- Alzheimer's research & therapy 1
- Journal of neurochemistry 1
- Molecular neurodegeneration 1
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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However, all Aβ vaccines tested so far in people with disease have faced significant challenges, primarily due to inadequate immunogenicity and insufficient antibody titers required to clear, reduce, or slow amyloid pathology.
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In this small Phase 1 study in early AD, ALZ‑101 was not associated with clear safety signals and elicited strong, durable Aβ‑specific antibody responses.
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The promising results obtained with aducanumab and solanezumab against Alzheimer's disease (AD) strengthen the vaccine approach to prevent AD, despite of the many clinical setbacks.
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AV-1959 is a promising vaccine candidate capable of producing therapeutically potent anti-amyloid antibody in a broader population of vaccinated subjects with high MHC class II gene polymorphisms.