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Home › Research › Topics › transgenic-mice

transgenic-mice

9 studies tagged transgenic-mice, dated 1996-12-01 to 2013-01-01. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Changes of the enteric nervous system in amyloid-β protein precursor transgenic mice correlate with disease progression 2013-01-01
  2. Environmental enrichment prevents astroglial pathological changes in the hippocampus of APP transgenic mice, model of Alzheimer's disease 2012-09-28
  3. The Psen1-L166P-knock-in mutation leads to amyloid deposition in human wild-type amyloid precursor protein YAC transgenic mice 2012-03-29

Studies

9 studies carry this tag.

Date range

1996 to 2013

Top journals

  • Experimental neurology 2
  • Journal of Alzheimer's disease : JAD 2
  • Brain research 1
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1
  • Neurobiology of aging 1

7 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Changes of the enteric nervous system in amyloid-β protein precursor transgenic mice correlate with disease progression

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of Alzheimer's disease : JAD 2013-01-01 Biomarkers

    In Alzheimer's disease (AD), fatal neuronal cell loss occurs long before relevant evidence can lead to a reliable diagnosis.

  2. Environmental enrichment prevents astroglial pathological changes in the hippocampus of APP transgenic mice, model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Experimental neurology 2012-09-28 Biomarkers

    Alzheimer's disease (AD) is a neurodegenerative disease that affects neurons and glial cells and leads to dementia.

  3. The Psen1-L166P-knock-in mutation leads to amyloid deposition in human wild-type amyloid precursor protein YAC transgenic mice

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012-03-29 Biomarkers

    Genetically engineered mice have been generated to model cerebral β-amyloidosis, one of the hallmarks of Alzheimer disease (AD) pathology, based on the overexpression of a mutated cDNA of the amyloid-β precursor protein (AβPP) or by knock-in of the murine Aβpp gene alone or with presenilin1 mutations.

  4. Chronic cerebral hypoperfusion accelerates amyloid beta deposition in APPSwInd transgenic mice

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Brain research 2009-07-30 Biomarkers

    Chronic cerebral ischemia may accelerate clinicopathological changes in Alzheimer's disease.

  5. Synaptic contact number and size in stratum radiatum CA1 of APP/PS1DeltaE9 transgenic mice

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of aging 2008-03-11 Biomarkers

    Synaptic changes occur early in the course of Alzheimer's disease and are key to understanding the initial events in associated neurodegenerative processes.

  6. Time-dependent reduction in Abeta levels after intracranial LPS administration in APP transgenic mice

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Experimental neurology 2004-11-01 Biomarkers

    Inflammation has been argued to play a primary role in the pathogenesis of Alzheimer's disease (AD).

  7. AbetaPP induces cdk5-dependent tau hyperphosphorylation in transgenic mice Tg2576

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of Alzheimer's disease : JAD 2002-10-01 Biomarkers

    Previous studies of Abeta-induced neuronal damage of hippocampal cells in culture have provided strong evidence that deregulation of the Cdk5/p35 kinase system is involved in the neurodegeneration pathway.

  8. Astroglial expression of human alpha(1)-antichymotrypsin enhances alzheimer-like pathology in amyloid protein precursor transgenic mice

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The American journal of pathology 2000-12-01 Biomarkers

    Proteases and their inhibitors play key roles in physiological and pathological processes.

  9. Beta-secretase processing of the beta-amyloid precursor protein in transgenic mice is efficient in neurons but inefficient in astrocytes

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of biological chemistry 1996-12-01 Biomarkers

    Alzheimer's disease is characterized by the extracellular deposition of beta-amyloid peptide (Abeta) in cerebral plaques and evidence is accumulating that amyloid is neurotoxic.

All topic tags with their study counts