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Home › Research › Topics › tdp-43

tdp-43

1,157 studies tagged tdp-43, dated 1986-01-01 to 2026-09-25. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. What Do Sugar, Gila Monsters, and the Therapeutic Dance Have in Common With GLP-1RA, Stroke, and Dementia? 2026-09-25
  2. Myo-inositol as a spectroscopic marker of neuroinflammation in frontotemporal lobar degeneration 2026-09-20
  3. Laromestrocel preserves brain volume and cognitive function in Alzheimers disease by inhibiting neuroinflammation 2026-09-17

Studies

1,157 studies carry this tag.

Date range

1986 to 2026

Top journals

  • The Journal of biological chemistry 109
  • The Journal of neuroscience : the official journal of the Society for Neuroscience 42
  • Proceedings of the National Academy of Sciences of the United States of America 39
  • Neuron 28
  • Nature 23

363 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Inhibition of glycogen synthase kinase-3 ameliorates β-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. The Journal of biological chemistry 2012-11-15 Risk genes beyond APOE

    Accumulation of β-amyloid (Aβ) deposits is a primary pathological feature of Alzheimer disease that is correlated with neurotoxicity and cognitive decline.

  2. Progranulin deficiency promotes neuroinflammation and neuron loss following toxin-induced injury

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. The Journal of clinical investigation 2012-10-08 Inflammation and the immune system

    Progranulin (PGRN) is a widely expressed secreted protein that is linked to inflammation.

  3. Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Molecular brain 2012-10-06 Lewy body dementia

    Pathogenic changes in the brain of a PARK2 patient were recapitulated using iPSC technology.

  4. The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. The Journal of biological chemistry 2012-10-03 Risk genes beyond APOE

    A disintegrin and metalloprotease 10 (ADAM10) is a ubiquitous transmembrane metalloprotease that cleaves the extracellular regions from over 40 different transmembrane target proteins, including Notch and amyloid precursor protein.

  5. Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Nature neuroscience 2012-09-30 Lewy body dementia

    FUS/TLS (fused in sarcoma/translocated in liposarcoma) and TDP-43 are integrally involved in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia.

  6. Dimebon alters hippocampal amyloid pathology in 3xTg-AD mice

    ✓ Peer-reviewed alzhub usefulness score 34 out of 100. International journal of physiology, pathophysiology and pharmacology 2012-09-20 Biomarkers

    A double blind, placebo-controlled phase II study revealed that the antihistamine, Dimebon® (dimebolin, latrepirdine) improved cognition in Alzheimer disease (AD) patients compared to placebo controls.

  7. Pinocembrin protects against β-amyloid-induced toxicity in neurons through inhibiting receptor for advanced glycation end products (RAGE)-independent signaling pathways and regulating mitochondrion-mediated apoptosis

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. BMC medicine 2012-09-18 Disease mechanisms

    Interaction between Aβ and the receptor for advanced glycation end products (RAGE) has been implicated in neuronal degeneration associated with this disease.

  8. β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. The Journal of biological chemistry 2012-09-17 Risk genes beyond APOE

    BACE1 is the β-secretase enzyme that initiates production of the β-amyloid peptide involved in Alzheimer disease.

  9. Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2012-09-01 Inflammation and the immune system

    Abnormal deposition and intercellular propagation of α-synuclein plays a central role in the pathogenesis of disorders such as Parkinson's Disease (PD) and dementia with Lewy bodies (DLB).

  10. Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2012-08-29 Lewy body dementia

    TDP-43 is a multifunctional DNA/RNA-binding protein that has been identified as the major component of the cytoplasmic ubiquitin (+) inclusions (UBIs) in diseased cells of frontotemporal lobar dementia (FTLD-U) and amyotrophic lateral sclerosis (ALS).

  11. Hyperphosphorylation of Tau induced by naturally secreted amyloid-β at nanomolar concentrations is modulated by insulin-dependent Akt-GSK3β signaling pathway

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. The Journal of biological chemistry 2012-08-21 Risk genes beyond APOE

    Alzheimer disease (AD) is neuropathologically characterized by the formation of senile plaques from amyloid-β (Aβ) and neurofibrillary tangles composed of phosphorylated Tau.

  12. Amyloid-β acts as a regulator of neurotransmitter release disrupting the interaction between synaptophysin and VAMP2

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. PloS one 2012-08-15 Disease mechanisms

    Our observations provide a necessary and timely insight into cellular mechanisms that underlie the initial pathological events that lead to synaptic dysfunction in Alzheimer's disease.

  13. GFAP isoforms in adult mouse brain with a focus on neurogenic astrocytes and reactive astrogliosis in mouse models of Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. PloS one 2012-08-13 Biomarkers

    Glial fibrillary acidic protein (GFAP) is the main astrocytic intermediate filament (IF).

  14. Stimulation of autophagy is neuroprotective in a mouse model of human tauopathy

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Autophagy 2012-08-09 Disease mechanisms

    The most common neurodegenerative diseases are characterized by the accumulation of misfolded proteins.

  15. The metalloprotease meprin β generates amino terminal-truncated amyloid β peptide species

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. The Journal of biological chemistry 2012-08-09 Risk genes beyond APOE

    The amyloid β (Aβ) peptide, which is abundantly found in the brains of patients suffering from Alzheimer disease, is central in the pathogenesis of this disease.

  16. Plasma long-chain omega-3 fatty acids and atrophy of the medial temporal lobe

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Neurology 2012-08-01 Brain scans and imaging

    The long-chain ω-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are potential candidates for interventions to delay Alzheimer disease (AD), but evidence from clinical studies is mixed.

  17. TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2012-08-01 Brain tissue and pathology

    Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) is a fatal neurodegenerative disease with no available treatments.

  18. Endotoxin-induced systemic inflammation activates microglia: [¹¹C]PBR28 positron emission tomography in nonhuman primates

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. NeuroImage 2012-07-06 Inflammation and the immune system

    Microglia play an essential role in many brain diseases.

  19. The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. The Journal of biological chemistry 2012-06-12 Risk genes beyond APOE

    The β-site amyloid precursor protein-cleaving enzyme BACE1 is a prime drug target for Alzheimer disease.

  20. Targeted delivery of nerve growth factor via encapsulated cell biodelivery in Alzheimer disease: a technology platform for restorative neurosurgery

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Journal of neurosurgery 2012-06-01 Brain scans and imaging

    Object The authors describe the first clinical trial with encapsulated cell biodelivery (ECB) implants that deliver nerve growth factor (NGF) to the cholinergic basal forebrain with the intention of halting the degeneration of cholinergic neurons and the associated cognitive decline in patients with Alzheimer disease (AD).

  21. Nuclear factor-κB regulates βAPP and β- and γ-secretases differently at physiological and supraphysiological Aβ concentrations

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. The Journal of biological chemistry 2012-05-31 Risk genes beyond APOE

    Anatomical lesions in Alzheimer disease-affected brains mainly consist of senile plaques, inflammation stigmata, and oxidative stress.

  22. Tumor necrosis factor-α synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Journal of neuroinflammation 2012-05-29 Risk genes beyond APOE

    Neuroinflammation is associated with virtually all major neurodegenerative disorders, including Alzheimer's disease (AD).

  23. Microglial activatory (immunoreceptor tyrosine-based activation motif)- and inhibitory (immunoreceptor tyrosine-based inhibition motif)-signaling receptors for recognition of the neuronal glycocalyx

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Glia 2012-05-21 TREM2 and immune genetics

    Microglia sense intact or lesioned cells of the central nervous system (CNS) and respond accordingly.

  24. Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. Nature 2012-05-16 Risk factors

    Human apolipoprotein E has three isoforms: APOE2, APOE3 and APOE4.

  25. Reduction of low-density lipoprotein receptor-related protein (LRP1) in hippocampal neurons does not proportionately reduce, or otherwise alter, amyloid deposition in APPswe/PS1dE9 transgenic mice

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Alzheimer's research & therapy 2012-04-26 Biomarkers

    Expression of LRP1 by neurons in proximity to senile amyloid plaques does not appear to play a major role in modulating the formation of these proximal deposits or in the appearance of the associated neuritic pathology.

  26. Role of phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) in intracellular amyloid precursor protein (APP) processing and amyloid plaque pathogenesis

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. The Journal of biological chemistry 2012-04-26 Genetics

    One of the pathological hallmarks of Alzheimer disease is the accumulation of amyloid plaques in the extracellular space in the brain.

  27. Effects of DHA-rich n-3 fatty acid supplementation on gene expression in blood mononuclear leukocytes: the OmegAD study

    ✓ Peer-reviewed alzhub usefulness score 65 out of 100. PloS one 2012-04-24 Treatments

    We suggest that 6 months of dietary n-3 FA supplementation affected expression of genes that might influence inflammatory processes and could be of significance for AD.

  28. NADPH oxidases: novel therapeutic targets for neurodegenerative diseases

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Trends in pharmacological sciences 2012-04-11 Inflammation and the immune system

    Oxidative stress is a key pathologic factor in neurodegenerative diseases such as Alzheimer and Parkinson diseases (AD, PD).

  29. Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuroscience letters 2012-04-10 Disease mechanisms

    Disruption of intracellular calcium homeostasis via abnormal and excessive activation of ryanodine receptors plays an important role in the neuropathology of Alzheimer's disease.

  30. Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Autophagy 2012-04-01 Disease mechanisms

    More than 30 neurodegenerative diseases including Alzheimer disease (AD), frontotemporal lobe dementia (FTD), and some forms of Parkinson disease (PD) are characterized by the accumulation of an aggregated form of the microtubule-binding protein tau in neurites and as intracellular lesions called neurofibrillary tangles.

  31. TDP-43 and FUS RNA-binding proteins bind distinct sets of cytoplasmic messenger RNAs and differently regulate their post-transcriptional fate in motoneuron-like cells

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. The Journal of biological chemistry 2012-03-16 Brain tissue and pathology

    The RNA-binding proteins TDP-43 and FUS form abnormal cytoplasmic aggregates in affected tissues of patients with amyotrophic lateral sclerosis and frontotemporal lobar dementia.

  32. A G-rich element forms a G-quadruplex and regulates BACE1 mRNA alternative splicing

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Journal of neurochemistry 2012-03-13 Risk genes beyond APOE

    β-Site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) is the transmembrane aspartyl protease that catalyzes the first cleavage step in the proteolysis of the APP to the amyloid β-protein (Aβ), a process involved in the pathogenesis of Alzheimer disease.

  33. Reduced expression of glucocorticoid-inducible genes GILZ and SGK-1: high IL-6 levels are associated with reduced hippocampal volumes in major depressive disorder

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Translational psychiatry 2012-03-13 Hippocampus size on brain scans

    Neuroplasticity may have a core role in the pathophysiology of major depressive disorder (MDD), a concept supported by experimental studies that found that excessive cortisol secretion and/or excessive production of inflammatory cytokines impairs neuronal plasticity and neurogenesis in the hippocampus.

  34. Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study

    ✓ Peer-reviewed alzhub usefulness score 67 out of 100. The Lancet. Neurology 2012-03-09 Disparities

    In patients with sporadic ALS, we identified the repeat expansion in 236 (7·0%) of 3377 white individuals from the USA, Europe, and Australia, two (4·1%) of 49 black individuals from the USA, and six (8·3%) of 72 Hispanic individuals from the USA.

  35. Rutin prevents cognitive impairments by ameliorating oxidative stress and neuroinflammation in rat model of sporadic dementia of Alzheimer type

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Neuroscience 2012-03-06 Biomarkers

    The objective of the present study was to assess the neuroprotective role of rutin (vitamin P) and delineate the mechanism of action.

  36. Phenolic compounds prevent amyloid β-protein oligomerization and synaptic dysfunction by site-specific binding

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of biological chemistry 2012-03-05 Disease mechanisms

    Cerebral deposition of amyloid β protein (Aβ) is an invariant feature of Alzheimer disease (AD), and epidemiological evidence suggests that moderate consumption of foods enriched with phenolic compounds reduce the incidence of AD.

  37. Low-density lipoprotein receptor represents an apolipoprotein E-independent pathway of Aβ uptake and degradation by astrocytes

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. The Journal of biological chemistry 2012-03-01 Genetics

    Accumulation of the amyloid β (Aβ) peptide within the brain is hypothesized to be one of the main causes underlying the pathogenic events that occur in Alzheimer disease (AD).

  38. Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo models

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Journal of neuroinflammation 2012-02-19 Biomarkers

    These results suggest that 4-O-methylhonokiol inhibits LPS-induced amyloidogenesis via anti-inflammatory mechanisms.

  39. Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Human molecular genetics 2012-02-09 Brain tissue and pathology

    Autosomal dominant cerebellar ataxia, deafness and narcolepsy (ADCA-DN) is characterized by late onset (30-40 years old) cerebellar ataxia, sensory neuronal deafness, narcolepsy-cataplexy and dementia.

  40. TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Proceedings of the National Academy of Sciences of the United States of America 2012-02-09 Lewy body dementia

    Although aberrant microRNA (miRNA) expression is linked to human diseases including cancer, the mechanisms that regulate the expression of each individual miRNA remain largely unknown.

  41. Sphingolipid-modulated exosome secretion promotes clearance of amyloid-β by microglia

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. The Journal of biological chemistry 2012-02-02 Inflammation and the immune system

    Amyloid β-peptide (Aβ), the pathogenic agent of Alzheimer disease, is a physiological metabolite whose levels are constantly controlled in normal brain.

  42. Inhibition of JNK by a peptide inhibitor reduces traumatic brain injury-induced tauopathy in transgenic mice

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neuropathology and experimental neurology 2012-02-01 Disease mechanisms

    Traumatic brain injury (TBI) is a major environmental risk factor for subsequent development of Alzheimer disease (AD).

  43. Endogenous TDP-43 localized to stress granules can subsequently form protein aggregates

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurochemistry international 2012-01-27 Clinical safety

    TDP-43 proteinopathies are characterized by loss of nuclear TDP-43 and accumulation of the protein in the cytosol as ubiquitinated protein aggregates.

  44. The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Brain research 2012-01-21 Lewy body dementia

    Prions are self-templating protein conformers that are naturally transmitted between individuals and promote phenotypic change.

  45. S-adenosylmethionine reduces the progress of the Alzheimer-like features induced by B-vitamin deficiency in mice

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neurobiology of aging 2012-01-04 Risk genes beyond APOE

    Methylation reactions linked to homocysteine in the one-carbon metabolism are increasingly elicited in Alzheimer's disease, although the association of hyperhomocysteinemia and of low B vitamin levels with the disease is still debated.

  46. Tannic acid is a natural β-secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-like pathology in transgenic mice

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. The Journal of biological chemistry 2012-01-04 Risk genes beyond APOE

    Amyloid precursor protein (APP) proteolysis is essential for production of amyloid-β (Aβ) peptides that form β-amyloid plaques in brains of Alzheimer disease (AD) patients.

  47. Correlation of amyloid PET ligand florbetapir F 18 binding with Aβ aggregation and neuritic plaque deposition in postmortem brain tissue

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Alzheimer disease and associated disorders 2012-01-01 Biomarkers

    Florbetapir F 18 selectively binds Aβ in human brain tissue.

  48. Evidence for astrocytosis in prodromal Alzheimer disease provided by 11C-deuterium-L-deprenyl: a multitracer PET paradigm combining 11C-Pittsburgh compound B and 18F-FDG

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2012-01-01 Brain scans and imaging

    Increased (11)C-DED binding throughout the brain of the MCI (11)C-PIB+ patients potentially suggests that astrocytosis is an early phenomenon in AD development.

  49. Microglial activation and TDP-43 pathology correlate with executive dysfunction in amyotrophic lateral sclerosis

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Acta neuropathologica 2012-01-01 Cognitive tests and assessment

    While cognitive deficits are increasingly recognized as common symptoms in amyotrophic lateral sclerosis (ALS), the underlying histopathologic basis for this is not known, nor has the relevance of neuroinflammatory mechanisms and microglial activation to cognitive impairment (CI) in ALS been systematically analyzed.

  50. Therapeutic effect of CHF5074, a new γ-secretase modulator, in a mouse model of scrapie

    ✓ Peer-reviewed alzhub usefulness score 29 out of 100. Prion 2012-01-01 Biomarkers

    In Transmissible Spongiform Encephalopathies (TSEs) and Alzheimer disease (AD) both misfolding and aggregation of specific proteins represent key features.

From across this tag

10 of the 1,153 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

All topic tags with their study counts