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Home › Research › Topics › tau

tau

751 studies tagged tau, dated 1986-05-01 to 2026-10-19. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Genetic Architecture of Plasma Amyloid and Tau Biomarkers in the Amish 2026-10-19
  2. Elevation in Plasma p-tau217 Concentrations Among Blood Donors: An Exploratory Cross-Sectional Study 2026-09-24
  3. A Harmonized Visual Reading Framework for Tau PET Staging in Alzheimer Disease 2026-09-21

Studies

751 studies carry this tag.

Date range

1986 to 2026

Top journals

  • Neurology 52
  • Alzheimer s & Dementia 50
  • JAMA neurology 42
  • Brain : a journal of neurology 24
  • The Journal of biological chemistry 22

233 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Tauopathy PET and amyloid PET in the diagnosis of chronic traumatic encephalopathies: studies of a retired NFL player and of a man with FTD and a severe head injury

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Translational psychiatry 2014-09-16 Disease mechanisms

    Single, severe traumatic brain injury (TBI) which elevates CNS amyloid, increases the risk of Alzheimer's disease (AD); while repetitive concussive and subconcussive events as observed in athletes and military personnel, may increase the risk of chronic traumatic encephalopathy (CTE).

  2. Huntington's disease is a four-repeat tauopathy with tau nuclear rods

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nature medicine 2014-07-20 Disease mechanisms

    An imbalance of tau isoforms containing either three or four microtubule-binding repeats causes frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) in families with intronic mutations in the MAPT gene.

  3. Physiological and pathological phosphorylation of tau by Cdk5

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Frontiers in molecular neuroscience 2014-07-15 Disease mechanisms

    Hyperphosphorylation of microtubule-associated protein tau is one of the major pathological events in Alzheimer's disease (AD) and other related neurodegenerative diseases, including frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17).

  4. Divergent CSF τ alterations in two common tauopathies: Alzheimer's disease and progressive supranuclear palsy

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Journal of neurology, neurosurgery, and psychiatry 2014-06-04 Cognitive tests and assessment

    Elevated CSF τ is considered a biomarker of neuronal injury in newly developed Alzheimer's disease (AD) and mild cognitive impairment (MCI) criteria.

  5. Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuropharmacology 2014-05-29 Disease mechanisms

    In a variety of neurodegenerative tauopathies including Alzheimer's disease, frontotemporal dementia and some types of Parkinson's disease, tau protein is abnormally hyperphosphorylated by several kinases and eventually aggregates to form neurofibrillary tangles, a neurotoxic pathological characteristic that closely correlates with cognitive impairments.

  6. Cerebrospinal fluid sphingolipids, β-amyloid, and tau in adults at risk for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of aging 2014-05-27 Biomarkers

    Cellular studies suggest sphingolipids may cause or accelerate amyloid-beta (Aβ) and tau pathology but in vivo human studies are lacking.

  7. Diagnostic performance of cerebrospinal fluid total tau and phosphorylated tau in Creutzfeldt-Jakob disease: results from the Swedish Mortality Registry

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. JAMA neurology 2014-04-01 Tau biomarkers

    Identifying a clinical distinction between the invariably lethal prion disease Creutzfeldt-Jakob disease (CJD) and nonprion rapidly progressive dementias is important and sometimes difficult; thus, reliable tools for diagnosis are in great demand.

  8. An epigenetic signature in peripheral blood associated with the haplotype on 17q21.31, a risk factor for neurodegenerative tauopathy

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. PLoS genetics 2014-03-06 Disease mechanisms

    Little is known about how changes in DNA methylation mediate risk for human diseases including dementia.

  9. Quantification of tau in cerebrospinal fluid by immunoaffinity enrichment and tandem mass spectrometry

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Clinical chemistry 2014-02-24 Tau biomarkers

    Cerebrospinal fluid (CSF) tau is a common biomarker for Alzheimer disease (AD).

  10. In vivo evaluation of a novel tau imaging tracer for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. European journal of nuclear medicine and molecular imaging 2014-02-11 Hippocampus size on brain scans

    (18)F-THK523 does not bind to Aβ in vivo, while following the known distribution of paired helical filaments (PHF)-tau in the brain.

  11. Tau-aggregation inhibitor therapy for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Biochemical pharmacology 2013-12-19 Brain tissue and pathology

    Many trials of drugs aimed at preventing or clearing β-amyloid pathology have failed to demonstrate efficacy in recent years and further trials continue with drugs aimed at the same targets and mechanisms.

  12. Reduced CSF p-Tau181 to Tau ratio is a biomarker for FTLD-TDP

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Neurology 2013-10-30 Tau biomarkers

    Antemortem CSF samples were collected from 30 patients with FTLD in a single-center validation cohort, and CSF levels of 5 putative FTLD-TDP biomarkers as well as levels of total Tau (t-Tau) and Tau phosphorylated at threonine 181 (p-Tau181) were measured using independent assays.

  13. Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F18]-T808

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Journal of Alzheimer s Disease 2013-10-29 Tau biomarkers

    Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease.

  14. Two novel Tau antibodies targeting the 396/404 region are primarily taken up by neurons and reduce Tau protein pathology

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of biological chemistry 2013-10-02 Inflammation and the immune system

    Aggregated Tau proteins are hallmarks of Alzheimer disease and other tauopathies.

  15. Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuron 2013-09-01 Disease mechanisms

    Accumulation of intracellular tau fibrils has been the focus of research on the mechanisms of neurodegeneration in Alzheimer's disease (AD) and related tauopathies.

  16. Globular glial tauopathies (GGT): consensus recommendations

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Acta neuropathologica 2013-08-31 Disease mechanisms

    Recent studies have highlighted a group of 4-repeat (4R) tauopathies that are characterised neuropathologically by widespread, globular glial inclusions (GGIs).

  17. Enhanced taupathy and AD-like pathology in aged primate brains decades after infantile exposure to lead (Pb)

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurotoxicology 2013-08-21 Risk genes beyond APOE

    Late Onset Alzheimer Disease (LOAD) constitutes the majority of AD cases (∼90%).

  18. Hyperphosphorylation-induced tau oligomers

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Frontiers in neurology 2013-08-15 Down syndrome and Alzheimer's

    In normal adult brain the microtubule associated protein (MAP) tau contains 2-3 phosphates per mol of the protein and at this level of phosphorylation it is a soluble cytosolic protein.

  19. Acetylated tau neuropathology in sporadic and hereditary tauopathies

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. The American journal of pathology 2013-08-01 Risk genes beyond APOE

    We have recently shown acetylation of tau at lysine residue 280 (AC-K280) to be a disease-specific modification in Alzheimer disease (AD), corticobasal degeneration, and progressive supranuclear palsy, likely representing a major regulatory tau modification.

  20. The importance of tau phosphorylation for neurodegenerative diseases

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Frontiers in neurology 2013-07-01 Lewy body dementia

    Fibrillar deposits of highly phosphorylated tau are a key pathological feature of several neurodegenerative tauopathies including Alzheimer's disease (AD) and some frontotemporal dementias.

  21. An unbiased approach to identifying tau kinases that phosphorylate tau at sites associated with Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. The Journal of biological chemistry 2013-06-24 Tau biomarkers

    Neurofibrillary tangles, one of the hallmarks of Alzheimer disease (AD), are composed of paired helical filaments of abnormally hyperphosphorylated tau.

  22. Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F-18]-T807

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Journal of Alzheimer s Disease 2013-06-20 Tau biomarkers

    Aggregates of hyperphosphorylated tau (PHF-tau), such as neurofibrillary tangles, are linked to the degree of cognitive impairment in Alzheimer's disease.

  23. Tau pathology and neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. The Lancet. Neurology 2013-06-01 Lewy body dementia

    The pathway leading from soluble and monomeric to hyperphosphorylated, insoluble and filamentous tau protein is at the centre of many human neurodegenerative diseases, collectively referred to as tauopathies.

  24. Longitudinal assessment of tau and amyloid beta in cerebrospinal fluid of Parkinson disease

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. Acta neuropathologica 2013-05-04 Tau biomarkers

    Tau gene has been consistently associated with the risk of Parkinson disease in recent genome wide association studies.

  25. Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathies

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of biological chemistry 2013-04-30 Disease mechanisms

    Traumatic brain injury (TBI) is a serious problem that affects millions of people in the United States alone.

  26. A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric aβ, and frank neuronal loss

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2013-04-01 Risk genes beyond APOE

    Alzheimer's disease (AD) is hallmarked by amyloid plaques, neurofibrillary tangles, and widespread cortical neuronal loss (Selkoe, 2001).

  27. GWAS of Cerebrospinal Fluid Tau Levels Identifies Risk Variants for Alzheimer’s Disease

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Neuron 2013-04-01 Genetics

  28. mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Aging cell 2013-03-24 Risk factors

    Accumulation of tau is a critical event in several neurodegenerative disorders, collectively known as tauopathies, which include Alzheimer's disease and frontotemporal dementia.

  29. The intersection of amyloid β and tau in glutamatergic synaptic dysfunction and collapse in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Ageing research reviews 2013-03-22 Disease mechanisms

    The synaptic connections that form between neurons during development remain plastic and able to adapt throughout the lifespan, enabling learning and memory.

  30. Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2013-01-01 Lewy body dementia

    Tauopathies, including Alzheimer's disease (AD) and frontotemporal lobar degeneration with tau pathologies, are neurodegenerative diseases characterized by neurofibrillary tangles (NFTs) comprising filamentous tau protein.

  31. Small misfolded Tau species are internalized via bulk endocytosis and anterogradely and retrogradely transported in neurons

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. The Journal of biological chemistry 2012-11-27 Lewy body dementia

    The accumulation of Tau into aggregates is associated with key pathological events in frontotemporal lobe degeneration (FTD-Tau) and Alzheimer disease (AD).

  32. Soluble aβ promotes wild-type tau pathology in vivo

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2012-11-01 Disease mechanisms

    Growing evidence suggests that soluble Aβ species can drive Alzheimer disease (AD) pathogenesis by inducing a cascade of events including tau hyperphosphorylation, proteasome impairment, and synaptic dysfunction.

  33. Extracellular Tau levels are influenced by variability in Tau that is associated with tauopathies

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. The Journal of biological chemistry 2012-10-26 Tau biomarkers

    Tauopathies are a class of neurodegenerative diseases marked by intracellular aggregates of hyperphosphorylated Tau.

  34. Lack of tau proteins rescues neuronal cell death and decreases amyloidogenic processing of APP in APP/PS1 mice

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. The American journal of pathology 2012-09-28 Risk genes beyond APOE

    Lack of tau expression has been reported to protect against excitotoxicity and to prevent memory deficits in mice expressing mutant amyloid precursor protein (APP) identified in familial Alzheimer disease.

  35. The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The American journal of pathology 2012-08-04 Disease mechanisms

    In Alzheimer disease (AD), deposition of neurofibrillary tangles and loss of synapses in the neocortex and limbic system each correlate strongly with cognitive impairment.

  36. Tau alternative splicing in familial and sporadic tauopathies

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biochemical Society transactions 2012-08-01 Disease mechanisms

    Six tau isoforms differing in their affinity for microtubules are produced by alternative splicing from the MAPT (microtubule-associated protein tau) gene in adult human brain.

  37. Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neurodegenerative Diseases 2012-07-10 Laboratory science

    Acute injections of Aβ oligomers had no effect on p-tau epitopes but did result in elevation of phosphorylated/activated GSK3 (pGSK3).

  38. Low PiB PET retention in presence of pathologic CSF biomarkers in Arctic APP mutation carriers

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Neurology 2012-06-13 Brain scans and imaging

    The lack of fibrillar β-amyloid (Aβ) as visualized by PiB PET in APParc mutation carriers suggests, given the reduced glucose metabolism and levels of Aβ(1-42) in CSF, that other forms of Aβ such as oligomers and protofibrils are important for the pathologic processes leading to clinical Alzheimer disease.

  39. Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Human molecular genetics 2012-05-18 Disease mechanisms

    Increased Tau protein amyloidogenicity has been causatively implicated in several neurodegenerative diseases, collectively called tauopathies.

  40. Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Acta neuropathologica 2012-04-25 Disease mechanisms

    Neurofibrillary lesions of abnormal Tau are hallmarks of Alzheimer disease and frontotemporal dementias.

  41. Trans-cellular propagation of Tau aggregation by fibrillar species

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. The Journal of biological chemistry 2012-03-29 Lewy body dementia

    Aggregation of the microtubule associated protein Tau is associated with several neurodegenerative disorders, including Alzheimer disease and frontotemporal dementia.

  42. Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Cell 2012-03-01 Mild cognitive impairment

    cis-trans isomerization of proteins phosphorylated by proline-directed kinases is proposed to control numerous signaling molecules and is implicated in the pathogenesis of Alzheimer's and other diseases.

  43. Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 60 out of 100. Neuron 2012-02-01 Disease mechanisms

    This study examined a transgenic mouse model in which human tau P301L overexpression was restricted to layer II of the entorhinal cortex (EC-II).

  44. Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of biological chemistry 2011-11-04 Disease mechanisms

    Recent demonstrations that the secretion, uptake, and interneuronal transfer of tau can be modulated by disease-associated tau modifications suggest that secretion may be an important element in tau-induced neurodegeneration.

  45. Progression of tau pathology in cholinergic Basal forebrain neurons in mild cognitive impairment and Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. The American journal of pathology 2011-09-23 Mild cognitive impairment

    Tau is a microtubule-associated protein that forms neurofibrillary tangles (NFTs) in the selective vulnerable long projection neurons of the cholinergic basal forebrain (CBF) in Alzheimer's disease (AD).

  46. Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of biological chemistry 2011-08-12 Disease mechanisms

    The microtubule-associated protein Tau plays a critical role in the pathogenesis of Alzheimer disease and several related disorders (tauopathies).

  47. Soluble tau species, not neurofibrillary aggregates, disrupt neural system integration in a tau transgenic model

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neuropathology and experimental neurology 2011-07-01 Disease mechanisms

    Neurofibrillary tangles are a feature of Alzheimer disease and other tauopathies, and although they are generally believed to be markers of neuronal pathology, there is little evidence evaluating whether tangles directly impact neuronal function.

  48. P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. PloS one 2011-06-15 Disease mechanisms

    Tauopathies are neurodegenerative disorders characterized by the accumulation of abnormal tau protein leading to cognitive and/or motor dysfunction.

  49. Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a "P301L" tau knockin mouse

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of aging 2011-04-13 Disease mechanisms

    Tauopathies are characterized by hyperphosphorylation of the microtubule-associated protein tau and its accumulation into fibrillar aggregates.

  50. Hyperphosphorylated Tau in an α-synuclein-overexpressing transgenic model of Parkinson's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The European journal of neuroscience 2011-04-01 Disease mechanisms

    Although clinically distinct diseases, tauopathies and synucleinopathies share a common genesis and mechanisms, leading to overlapping degenerative changes within neurons.

From across this tag

9 of the 746 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

All topic tags with their study counts