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tacrine
4 studies tagged tacrine, dated 1994-06-01 to 2016-01-18. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease 2016-01-18
- Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice 2007-12-23
- Invited review: Cholinesterase inhibitors for Alzheimer's disease therapy: from tacrine to future applications 1998-05-01
Studies
4 studies carry this tag.
Date range
1994 to 2016
Top journals
- European journal of pharmacology 1
- Neurochemistry international 1
- Progress in neurobiology 1
- The Annals of pharmacotherapy 1
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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Alzheimer's disease is a multifactorial and fatal neurodegenerative disorder characterized by decline of cholinergic function, deregulation of other neurotransmitter systems, β-amyloid fibril deposition, and β-amyloid oligomers formation.
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Oxidative stress is a major factor implicated in the degeneration of cholinergic neurons in Alzheimer's disease.
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This review starts with an historical background of the pharmacological development of tacrine almost fifty years ago (1949).
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Adverse effects are frequent, and significantly elevated hepatic transaminase concentrations may occur in approximately 25 percent of patients.