Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest in this topic

  1. Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease 2016-01-18
  2. Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice 2007-12-23
  3. Invited review: Cholinesterase inhibitors for Alzheimer's disease therapy: from tacrine to future applications 1998-05-01

Studies

4 studies carry this tag.

Date range

1994 to 2016

Top journals

  • European journal of pharmacology 1
  • Neurochemistry international 1
  • Progress in neurobiology 1
  • The Annals of pharmacotherapy 1

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Progress in neurobiology 2016-01-18 Treatments

    Alzheimer's disease is a multifactorial and fatal neurodegenerative disorder characterized by decline of cholinergic function, deregulation of other neurotransmitter systems, β-amyloid fibril deposition, and β-amyloid oligomers formation.

  2. Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. European journal of pharmacology 2007-12-23 Treatments

    Oxidative stress is a major factor implicated in the degeneration of cholinergic neurons in Alzheimer's disease.

  3. Invited review: Cholinesterase inhibitors for Alzheimer's disease therapy: from tacrine to future applications

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Neurochemistry international 1998-05-01 Treatments

    This review starts with an historical background of the pharmacological development of tacrine almost fifty years ago (1949).

  4. Tacrine: first drug approved for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Annals of pharmacotherapy 1994-06-01 Treatments

    Adverse effects are frequent, and significantly elevated hepatic transaminase concentrations may occur in approximately 25 percent of patients.

All topic tags with their study counts