sporadic

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

1. 41/100

   Inhibition of asparagine endopeptidase (AEP) effectively treats sporadic Alzheimer's disease in mice

   ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023-11-29 · Biomarkers

   Alzheimer's disease (AD) is a progressive neurodegenerative disease with cognitive dysfunction as its major clinical symptom.

   • Brain Biology
2. 43/100

   Serum neurofilament light chain as a surrogate of cognitive decline in sporadic and familial frontotemporal dementia

   ✓ Peer-reviewed alzhub usefulness score 43 out of 100. European journal of neurology · 2021-09-03 · Biomarkers

   Our findings highlight the potential of serum NfL as a useful surrogate end point of disease severity in upcoming targeted treatments.

   • Biomarkers
   • Genetics
   • Other Dementias
3. 48/100

   Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer's disease

   ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Alzheimer's research & therapy · 2019-03-21 · Biomarkers

   Concentrations of Aβ 40 and Aβ 42 were much higher in adults with DS than in other groups, reflecting APP gene triplication, while no difference in the Aβ 42 /Aβ 40 ratio between those with DS and sAD may indicate similar processing and deposition of Aβ 40 and Aβ 42 in these groups.

   • Biomarkers
   • Down Syndrome
4. 47/100

   Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms

   ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association · 2017-09-21 · Genetics

   Our analysis confirms that the genetic factors identified for LOAD modulate risk in sLOAD and fLOAD and also sEOAD cohorts.

   • Genetics
5. 47/100

   Regional distribution of synaptic markers and APP correlate with distinct clinicopathological features in sporadic and familial Alzheimer's disease

   ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Brain : a journal of neurology · 2014-03-12 · Biomarkers

   Recent studies suggest that subcortical structures, including striatum, are vulnerable to amyloid-β accumulation and other neuropathological features in familial Alzheimer's disease due to autosomal dominant mutations.

   • Genetics
   • Brain Biology
   • Digital Tools
6. 45/100

   Combination of plasma biomarkers and clinical data for the detection of sporadic Alzheimer's disease

   ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Neuroscience letters · 2012-04-07 · Biomarkers

   Amyloid β and alpha 1-antichymotrypsin (ACT) play an important role in the pathogenesis of sporadic Alzheimer's disease (AD).

   • Biomarkers
7. 36/100

   Potential utility of soluble p3-alcadein α plasma levels as a biomarker for sporadic Alzheimer's disease

   ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of Alzheimer's disease : JAD · 2012-01-01 · Biomarkers

   Alcadeins (Alcs) constitute a family of neuronal type I membrane proteins (α, β, γ) that share identical localization and function to the amyloid-β protein precursor (AβPP) in the brain.

   • Biomarkers

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