sh-sy5y-cells

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

1. 43/100

   The Impact of Differentiation on Cytotoxicity and Insulin Sensitivity in Streptozotocin Treated SH-SY5Y Cells

   ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Neurochemical research · 2021-02-22 · Drug development

   Recently neuronal insulin resistance was suggested playing a role in Alzheimer's disease.

2. 41/100

   Liraglutide Attenuates Aβ42 Generation in APPswe/SH-SY5Y Cells Through the Regulation of Autophagy

   ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neuropsychiatric disease and treatment · 2020-07-27 · Drug development

   Here, we report a novel mechanism underlying liraglutide-attenuated Aβ42 generation through the activation of autophagy in AD cellular model.

   • Policy
3. 38/100

   The protective effects of liraglutide on AD-like neurodegeneration induced by oxidative stress in human neuroblastoma SH-SY5Y cells

   ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Chemico-biological interactions · 2019-06-04 · Drug development

   Glucagon-like peptide 1 (GLP-1) has neuroprotective properties in Alzheimer's disease (AD).

   • Brain Biology
   • Treatments
4. 41/100

   Olive Biophenols Reduces Alzheimer's Pathology in SH-SY5Y Cells and APPswe Mice

   ✓ Peer-reviewed alzhub usefulness score 41 out of 100. International journal of molecular sciences · 2018-12-30 · Treatments

   Alzheimer's disease (AD) is a major neurodegenerative disease, associated with the hallmark proteinacious constituent called amyloid beta (Aβ) of senile plaques.

   • Treatments
   • Brain Biology
5. 38/100

   Human neuroblastoma SH-SY5Y cells treated with okadaic acid express phosphorylated high molecular weight tau-immunoreactive protein species

   ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of neuroscience methods · 2018-09-29 · Drug development

   Our data provide a novel characterization of an OA-based cell culture model in which OA induces the appearance of HMW-TIPs.

   • Treatments
6. 38/100

   Evaluation of the Expression of Amyloid Precursor Protein and the Ratio of Secreted Amyloid Beta 42 to Amyloid Beta 40 in SH-SY5Y Cells Stably Transfected with Wild-Type, Single-Mutant and Double-Mutant Forms of the APP Gene for the Study of Alzheimer's Disease Pathology

   ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Applied biochemistry and biotechnology · 2017-04-17 · Biomarkers

   Neuroblastoma cell lines such as SH-SY5Y are the most frequently utilized models in neurodegenerative research, and their use has advanced the understanding of the pathology of neurodegeneration over the past few decades.

   • Genetics
   • Brain Biology
   • Biomarkers
7. 36/100

   Liraglutide prevents beta-amyloid-induced neurotoxicity in SH-SY5Y cells via a PI3K-dependent signaling pathway

   ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurological research · 2016-04-23 · Drug development

   These findings suggest that liraglutide prevented Aβ (25-35)-induced neurotoxicity by inhibiting neuronal apoptosis and liraglutide may have a neuroprotective effect through activation of the PI3K/Akt signaling pathway.

   • Brain Biology
   • Treatments
   • Prevention
8. 36/100

   Neuroprotective effect of 3,5-di-O-caffeoylquinic acid on SH-SY5Y cells and senescence-accelerated-prone mice 8 through the up-regulation of phosphoglycerate kinase-1

   ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuroscience · 2010-06-04 · Genetics

   As aged population dramatically increases in these decades, efforts should be made on the intervention for curing age-associated neurologic degenerative diseases such as Alzheimer's disease (AD).

   • Brain Biology

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