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secretase-inhibitors
2 studies tagged secretase-inhibitors, dated 2021-01-02 to 2022-12-28. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
Studies
2 studies carry this tag.
Date range
2021 to 2022
Top journals
- Pharmacological research 1
- The oncologist 1
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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According to the β-amyloid (Aβ) hypothesis of Alzheimer's disease (AD), brain Aβ accumulation is the primary cascade event leading to cognitive deficit and dementia.
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Gamma secretase inhibitors (GSIs), initially developed as Alzheimer's therapies, have been repurposed as anticancer agents given their inhibition of Notch receptor cleavage.