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receptor-antagonist
3 studies tagged receptor-antagonist, dated 1995-08-01 to 2009-11-16. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- GluN2B subunit-containing NMDA receptor antagonists prevent Abeta-mediated synaptic plasticity disruption in vivo 2009-11-16
- Paradigm shift in NMDA receptor antagonist drug development: molecular mechanism of uncompetitive inhibition by memantine in the treatment of Alzheimer's disease and other neurologic disorders 2004-12-01
- Cerebrospinal fluid and serum concentrations of the N-methyl-D-aspartate (NMDA) receptor antagonist memantine in man 1995-08-01
Studies
3 studies carry this tag.
Date range
1995 to 2009
Top journals
- Journal of Alzheimer's disease : JAD 1
- Neuroscience letters 1
- Proceedings of the National Academy of Sciences of the United States of America 1
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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Currently, treatment with the relatively low-affinity NMDA receptor antagonist memantine provides limited benefit in Alzheimer's disease (AD).
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Recent phase 3 clinical trials have shown that memantine is effective in the treatment of moderate-to-severe Alzheimer's disease and possibly vascular dementia (multi-infarct dementia).
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Memantine is an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist with therapeutic potential in dementia, spasticity and Parkinson's disease.