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rat-brain
6 studies tagged rat-brain, dated 1988-05-01 to 2023-01-01. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- Intracellular Amyloid-β in the Normal Rat Brain and Human Subjects and Its relevance for Alzheimer's Disease 2023-01-01
- Oligomers of β-amyloid protein (Aβ1-42) induce the activation of cyclooxygenase-2 in astrocytes via an interaction with interleukin-1β, tumour necrosis factor-α, and a nuclear factor κ-B mechanism in the rat brain 2012-05-14
- Amyloid beta-protein (Abeta)1-40 protects neurons from damage induced by Abeta1-42 in culture and in rat brain 2003-11-01
Studies
6 studies carry this tag.
Date range
1988 to 2023
Top journals
- Brain research bulletin 1
- Experimental neurology 1
- Journal of Alzheimer's disease : JAD 1
- Journal of neurochemistry 1
- The American journal of pathology 1
6 journals in all.
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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Expression of iAβ42 in healthy Wistar rats predominates in the same structures where iAβ accumulates and Aβ plaques initially form in the much used, Wistar based McGill-R-Thy1-APP rat model for AD.
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Despite growing evidence indicating the effects of cytokines, including interleukin-1beta (IL-1β) and tumour necrosis factor-α (TNFα), and the enzyme cyclooxygenase-2 (COX-2) in Alzheimer's diseases, little is known about the signalling mechanisms that mediate its activation in response to beta-amyloid protein (Aβ).
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Previously, we found that amyloid beta-protein (Abeta)1-42 exhibits neurotoxicity, while Abeta1-40 serves as an antioxidant molecule by quenching metal ions and inhibiting metal-mediated oxygen radical generation.
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Although the neurotoxic actions of aluminium (Al) have been well documented, its contribution to neurodegenerative diseases such as Alzheimer's disease remains controversial.
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The presence of extracellular deposits of beta-amyloid protein in the brain is a hallmark of Alzheimer's disease (AD).
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The cloned cDNA encoding the rat cognate of the human A4 amyloid precursor protein was isolated from a rat brain library.