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Home › Research › Topics › profound

profound

3 studies tagged profound, dated 2001-08-01 to 2022-06-11. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia 2022-06-11
  2. A novel presenilin 2 mutation (V393M) in early-onset dementia with profound language impairment 2008-08-22
  3. Behavioral phenotyping of GFAP-apoE3 and -apoE4 transgenic mice: apoE4 mice show profound working memory impairments in the absence of Alzheimer's-like neuropathology 2001-08-01

Studies

3 studies carry this tag.

Date range

2001 to 2022

Top journals

  • European journal of neurology 1
  • Experimental neurology 1
  • Molecular neurodegeneration 1

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Molecular neurodegeneration 2022-06-11 Genetics

    Our findings demonstrate that fibrillar Aβ in microglia is associated with lipid dyshomeostasis consistent with lysosomal dysfunction and foam cell phenotypes as well as profound immuno-metabolic perturbations, opening new avenues to further investigate metabolic pathways at play in microglia responding to AD-relevant pathogenesis.

  2. A novel presenilin 2 mutation (V393M) in early-onset dementia with profound language impairment

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. European journal of neurology 2008-08-22 Biomarkers

    The possible pathogenic nature of the mutation is not clarified.

  3. Behavioral phenotyping of GFAP-apoE3 and -apoE4 transgenic mice: apoE4 mice show profound working memory impairments in the absence of Alzheimer's-like neuropathology

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Experimental neurology 2001-08-01 Biomarkers

    For the purpose of studying the potential neurobehavioral effects of different human apolipoprotein E (apoE) isoforms produced within the brain, transgenic (TG) mice were generated in which human apoE3 or apoE4 isoforms were under control of an astrocyte-specific, glial fibrillary acidic protein promoter and these TG mice were bred back to apoE knockout (KO) mice.

All topic tags with their study counts