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Home › Research › Topics › precursor

precursor

1,346 studies tagged precursor, dated 1982-09-01 to 2026-10-18. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Evidence for Reduced Somatic T-Cell Receptor Sequence Diversity Profiles Among Midwestern Amish in an Aging Cohort Study 2026-10-18
  2. Gantenerumab reduces brain amyloid-β proteoforms: Biochemical evaluation in dominantly inherited Alzheimer disease 2026-09-29
  3. Genetic Insights Into Protective Effects of GLP-1 Receptor Agonists on Stroke and Alzheimer Disease Across Ancestries 2026-09-25

Studies

1,346 studies carry this tag.

Date range

1982 to 2026

Top journals

  • Neurology 92
  • The Journal of biological chemistry 67
  • Proceedings of the National Academy of Sciences of the United States of America 47
  • Archives of neurology 43
  • JAMA neurology 36

372 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Activated Alzheimer disease platelets retain more beta amyloid precursor protein

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neurobiology of aging 1997-03-01 Risk genes beyond APOE

    Upon activation, platelet alpha-granules' soluble contents are secreted and membrane-bound contents are translocated to the plasma membrane.

  2. Analysis of the 5' sequence, genomic structure, and alternative splicing of the presenilin-1 gene (PSEN1) associated with early onset Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Genomics 1997-03-01 Risk genes beyond APOE

    Mutations in the human presenilin genes (PSEN1 and PSEN2) are associated with early onset familial Alzheimer disease.

  3. Clinicopathological features of familial Alzheimer's disease associated with the M139V mutation in the presenilin 1 gene. Pedigree but not mutation specific age at onset provides evidence for a further genetic factor

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Brain : a journal of neurology 1997-03-01 Digital health tools

    Sixteen affected individuals are described from two families with early onset autosomal dominant familial Alzheimer's disease.

  4. Glial-neuronal interactions in Alzheimer disease: progressive association of IL-1alpha+ microglia and S100beta+ astrocytes with neurofibrillary tangle stages

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neuropathology and experimental neurology 1997-03-01 Inflammation and the immune system

    Activated microglia, overexpressing interleukin-1 (IL-1), and activated astrocytes, overexpressing S100beta, have been implicated in the formation and evolution of tau2-immunoreactive (tau2+) neuritic plaques in Alzheimer disease.

  5. Secretory processing of amyloid precursor protein is inhibited by increase in cellular cholesterol content

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. The Biochemical journal 1997-03-01 Risk genes beyond APOE

    Plasma-membrane composition plays a crucial role in most of the cellular functions that depend on membrane processes.

  6. The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1997-03-01 Risk genes beyond APOE

    To gain insights into the significance of presenilins (PS) in the pathogenetic mechanisms of early-onset familial Alzheimer disease (FAD), we expressed cDNAs for wild-type PS2 and PS2 with the Volga German (N141I) mutation in cultured cells and then examined the metabolism of the transfected proteins and their effect on the C-terminal properties of secreted amyloid beta protein (A beta).

  7. Altered amyloid protein processing in platelets of patients with Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Archives of neurology 1997-02-01 Risk genes beyond APOE

    Alternate cleavage products of intact 140- to 150-kd APPs in platelets include nonamyloidogenic 120- to 130-kd and 110-kd isoforms.

  8. Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1997-02-01 Risk genes beyond APOE

    The PDAPP transgenic mouse, which overexpresses human amyloid precursor protein (APP717V-->F), has been shown to develop much of the pathology associated with Alzheimer disease.

  9. Apolipoprotein E and Alzheimer disease: genotype-specific risks by age and sex

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. American journal of human genetics 1997-02-01 Genetics

    The distribution of apolipoprotein E (APOE) genotypes as a function of age and sex has been examined in a French population of 417 Alzheimer disease (AD) patients and 1,030 control subjects.

  10. Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam Study

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. Lancet (London, England) 1997-01-01 How common it is

    All indicators of atherosclerosis were associated with dementia (odds ratios ranging from 1.3 to 1.9) and its major subtypes Alzheimer's disease (odds ratios 1.3-1.8) and vascular dementia (odds ratios 1.9-3.2).

  11. Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Science (New York, N.Y.) 1996-12-01 Risk genes beyond APOE

    Overexpression of the familial Alzheimer's disease gene Presenilin 2 (PS2) in nerve growth factor-differentiated PC12 cells increased apoptosis induced by trophic factor withdrawal or beta-amyloid.

  12. Evidence for physiological down-regulation of brain oxidative phosphorylation in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Experimental neurology 1996-11-01 Disease mechanisms

    In vivo imaging of patients with Alzheimer's disease using positron emission tomography (PET) demonstrates progressive reductions in brain glucose metabolism and blood flow in relation to dementia severity, more so in association than primary cortical regions.

  13. Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1996-11-01 Risk genes beyond APOE

    Cerebral deposition of the amyloid beta protein (A beta) is an early and invariant feature of Alzheimer disease (AD).

  14. Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. Science 1996-10-04 Laboratory science

    Transgenic mice overexpressing the 695-amino acid isoform of human Alzheimer beta-amyloid (Abeta) precursor protein containing a Lys670 --> Asn, Met671 --> Leu mutation had normal learning and memory in spatial reference and alternation tasks at 3 months of age but showed impairment by 9 to 10 months of age.

  15. Familial amyotrophic lateral sclerosis with a mutation in exon 4 of the Cu/Zn superoxide dismutase gene: pathological and immunocytochemical changes

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Acta neuropathologica 1996-10-01 Clinical safety

    Detailed molecular pathology studies and clinicopathological phenotyping of familial amyotrophic lateral sclerosis (FALS) with characterised mutations in the gene encoding Cu/Zn superoxide dismutase (SOD1) will yield important insights into the pathogenesis of motor neuron degeneration.

  16. Specific domains of beta-amyloid from Alzheimer plaque elicit neuron killing in human microglia

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 1996-10-01 Inflammation and the immune system

    Alzheimer's disease (AD) is found to have striking brain inflammation characterized by clusters of reactive microglia that surround senile plaques.

  17. The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Nature medicine 1996-10-01 Risk genes beyond APOE

    Missense mutations in the presenilin 1 (PS1) gene cause the most common form of dominant early-onset familial Alzheimer's disease (FAD) and are associated with increased levels of amyloid beta-peptides (A beta) ending at residue 42 (A beta 42) in plasma and skin fibroblast media of gene carriers.

  18. In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Neurobiology of aging 1996-09-01 Risk genes beyond APOE

    Interleukin-1 (IL-1), an inflammatory cytokine overexpressed in the neuritic plaques of Alzheimer's disease, activates astrocytes and enhances production and processing of beta-amyloid precursor protein (beta-APP).

  19. RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. Nature 1996-08-01 Disease mechanisms

  20. Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Nature Medicine 1996-08-01 Risk genes beyond APOE

  21. Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 1996-07-01 Getting a diagnosis

    The entorhinal cortex (EC) plays a crucial role as a gateway connecting the neocortex and the hippocampal formation.

  22. Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease: the CERAD experience, Part XV

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Neurology 1996-06-01 Brain tissue and pathology

    We studied the frequency, severity, and clinical correlations of cerebral amyloid angiopathy (CAA) in 117 CERAD subjects with autopsy-confirmed AD.

  23. Expression of apolipoprotein E mRNA in rat microglia

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Neuroscience letters 1996-06-01 Genetics

    Apolipoprotein E (apoE) is a major risk factor for Alzheimer disease (AD), which is the most common cause of progressive dementing illness.

  24. Gender difference in apolipoprotein E-associated risk for familial Alzheimer disease: a possible clue to the higher incidence of Alzheimer disease in women

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. American journal of human genetics 1996-04-01 Genetics

    Late-onset Alzheimer disease (AD) is associated with the apolipoprotein E (APOE)-epsilon4 allele.

  25. Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. The New England journal of medicine 1996-03-01 Risk factors

    In late middle age, cognitively normal subjects who are homozygous for the epsilon 4 allele for apolipoprotein E have reduced glucose metabolism in the same regions of the brain as in patients with probable Alzheimer's disease.

  26. Relative risk of Alzheimer disease and age-at-onset distributions, based on APOE genotypes among elderly African Americans, Caucasians, and Hispanics in New York City

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. American journal of human genetics 1996-03-01 Genetics

    Apolipoprotein-E epsilon 4 (APOE-epsilon 4) has been consistently associated with Alzheimer disease (AD) and may be responsible for an earlier age at onset.

  27. Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease. Alzheimer's Disease Collaborative Group

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Lancet (London, England) 1996-02-01 Genetics

    Homozygosity of the 1 allele in the PS-1 gene was associated with a doubling of the risk for late-onset Alzheimer's disease compared with the [12]/[22] genotype (odds ratio 1.97, 95% Cl 1.29-3.00).

  28. Production and increased detection of amyloid beta protein and amyloidogenic fragments in brain microvessels, meningeal vessels and choroid plexus in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Brain research. Molecular brain research 1996-01-01 Risk genes beyond APOE

    Recent advances indicate soluble amyloid beta (A beta) protein is produced constitutively during normal metabolism of the amyloid precursor protein (APP).

  29. Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1995-12-01 Genetics

    Apolipoprotein E (apoE) is critical in the modulation of cholesterol and phospholipid transport between cells of different types.

  30. Episodic memory changes are associated with the APOE-epsilon 4 allele in nondemented older adults

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Neurology 1995-12-01 Genetics

    APOE- epsilon 4 and non-epsilon 4 groups did not significantly differ in demographic, mental status, and functional characteristics.

  31. Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Neuron 1995-11-01 Risk genes beyond APOE

    Transgenic FVB/N mice overexpressing human (Hu) or mouse (Mo) Alzheimer amyloid precursor protein (APP695) die early and develop a CNS disorder that includes neophobia and impaired spatial alternation, with diminished glucose utilization and astrogliosis mainly in the cerebrum.

  32. Apolipoprotein E allele epsilon 4, dementia, and cognitive decline in a population sample

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Lancet (London, England) 1995-11-01 Brain tissue and pathology

    From clinically based series it has been proposed that, in homozygotes for the apolipoprotein E epsilon 4 (apoE epsilon 4) allele, Alzheimer's disease is almost inevitable by the age of 80.

  33. Apolipoprotein E, dementia, and cortical deposition of beta-amyloid protein

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. The New England journal of medicine 1995-11-01 How common it is

    Even in elderly subjects without dementia, the apolipoprotein E genotype is related to the degree of deposition of beta-amyloid protein in the cerebral cortex.

  34. Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Brain research. Molecular brain research 1995-10-01 Genetics

    This study examines the relationship between the levels of apolipoprotein E (apoE) and apolipoprotein J (apoJ, also designated as clusterin) as a function of apoE genotype in the hippocampus and cortex of Alzheimer disease (AD) subjects.

  35. Regulated formation of Golgi secretory vesicles containing Alzheimer beta-amyloid precursor protein

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. The Journal of biological chemistry 1995-10-01 Risk genes beyond APOE

    Phorbol esters, activators of protein kinase C (PKC), regulate the relative utilization of alternative processing pathways for the Alzheimer beta-amyloid precursor protein (beta-APP) in intact cells, increasing the production of nonamyloidogenic soluble beta-APP (s beta-APP) and decreasing that of neurotoxic beta-amyloid (A beta) peptide.

  36. Candidate Gene for the Chromosome 1 Familial Alzheimer's Disease Locus

    ✓ Peer-reviewed alzhub usefulness score 60 out of 100. Science 1995-08-18 Risk genes beyond APOE

    A candidate gene for the chromosome 1 Alzheimer's disease (AD) locus was identified (STM2).

  37. Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Nature 1995-08-01 Risk genes beyond APOE

    The study reported the cloning of a novel gene (E5-1) encoded on chromosome 1 with sequence similarity to the S182 gene on chromosome 14q24.3.

  38. ApoE immunoreactivity and microglial cells in Alzheimer's disease brain

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Neuroscience letters 1995-07-01 Genetics

    The spatial relationship of apolipoprotein E (apoE)-like immunoreactivity (IR) to amyloid beta-peptide (A beta), astrocytes and microglial cells in the brain of Alzheimer's disease was studied by double immunolabelling.

  39. Age-related learning deficits in transgenic mice expressing the 751-amino acid isoform of human beta-amyloid precursor protein

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1995-06-01 Risk genes beyond APOE

    The beta-amyloid precursor protein (beta-APP), from which the beta-A4 peptide is derived, is considered to be central to the pathogenesis of Alzheimer disease (AD).

  40. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. Nature 1995-06-01 Genetics

    Researchers isolated transcripts from a chromosomal region linked to an aggressive form of Alzheimer's disease and identified a novel gene transcript.

  41. Apolipoprotein E status as a predictor of the development of Alzheimer's disease in memory-impaired individuals

    ✓ Peer-reviewed alzhub usefulness score 68 out of 100. JAMA 1995-04-01 Getting a diagnosis

    These data suggest the following: (1) patients with mild cognitive impairment can be clinically defined, (2) many members of this group progress to Alzheimer's disease, and (3) APOE epsilon 4 allele status appears to be a strong predictor of clinical progression.

  42. A severe loss of choline acetyltransferase in the frontal cortex of Alzheimer patients carrying apolipoprotein epsilon 4 allele

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Neuroscience letters 1995-03-01 Genetics

    We measured the activities of choline acetyltransferase (ChAT) in the post mortem frontal cortex in 32 Alzheimer's disease (AD) patients with different apolipoprotein E (apoE) genotypes.

  43. Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 65 out of 100. JAMA 1995-03-01 Genetics

    These results suggest that the inheritance of APOE epsilon 4 is associated with reduced cerebral parietal metabolism and increased asymmetry in non-demented relatives at risk for probable AD.

  44. Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. The Journal of biological chemistry 1995-03-01 Tau biomarkers

    Microtubule-associated protein tau is abnormally hyperphosphorylated in the brain of patients with Alzheimer disease and in this form is the major protein subunit of the paired helical filaments (PHF), the most prominent lesion of the disease.

  45. Inflammatory processes induce beta-amyloid precursor protein changes in mouse brain

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1995-03-01 Risk genes beyond APOE

    In Alzheimer disease, a combination of genetic predisposition and environmental factors may contribute to changes in beta-amyloid precursor protein (APP) expression, beta-amyloid peptide deposition, and neuronal loss.

  46. Muscarinic regulation of Alzheimer's disease amyloid precursor protein secretion and amyloid beta-protein production in human neuronal NT2N cells

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. The Journal of biological chemistry 1995-03-01 Risk genes beyond APOE

    The Alzheimer amyloid precursor protein (APP) undergoes complex processing resulting in the production of a 4-kDa amyloid peptide (A beta) which has been implicated in the pathogenesis of Alzheimer's disease.

  47. Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Nature 1995-02-01 Risk genes beyond APOE

    Alzheimer's disease (AD) is the most common cause of progressive intellectual failure in aged humans.

  48. Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1995-01-01 Genetics

    The apolipoprotein E4 (APOE4) allele is associated with an early age of onset of the nonfamilial form of Alzheimer disease (AD) and with increased beta protein amyloid deposition in the brain.

  49. Decreased phospholipase A2 activity in Alzheimer brains

    ✓ Peer-reviewed alzhub usefulness score 42 out of 100. Biological psychiatry 1995-01-01 Risk genes beyond APOE

    Phospholipase A2 (PLA2) is a key-enzyme in the metabolism of membrane phospholipids.

  50. Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Proceedings of the National Academy of Sciences of the United States of America 1994-12-01 Risk genes beyond APOE

    The 39- to 43-amino acid amyloid beta-protein (A beta), which is progressively deposited in cerebral plaques and blood vessels in Alzheimer disease (AD), is secreted by cultured human cells during normal metabolism.

From across this tag

8 of the 1,344 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 8. The same 8 appear here every time.

All topic tags with their study counts