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Home › Research › Topics › precursor-protein

precursor-protein

7 studies tagged precursor-protein, dated 1992-06-01 to 2013-10-24. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. Autosomal-dominant Alzheimer's disease mutations at the same codon of amyloid precursor protein differentially alter Aβ production 2013-10-24
  2. The Psen1-L166P-knock-in mutation leads to amyloid deposition in human wild-type amyloid precursor protein YAC transgenic mice 2012-03-29
  3. Platelet immunoglobulin and amyloid precursor protein as potential peripheral biomarkers for Alzheimer's disease: findings from a pilot study 2012-01-17

Studies

7 studies carry this tag.

Date range

1992 to 2013

Top journals

  • Age and ageing 1
  • Brain research. Molecular brain research 1
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1
  • Journal of neurochemistry 1
  • Molecular and cellular neurosciences 1

7 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Autosomal-dominant Alzheimer's disease mutations at the same codon of amyloid precursor protein differentially alter Aβ production

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neurochemistry 2013-10-24 Biomarkers

    Autosomal-dominant Alzheimer's disease (ADAD) is a genetic disorder caused by mutations in Amyloid Precursor Protein (APP) or Presenilin (PSEN) genes.

  2. The Psen1-L166P-knock-in mutation leads to amyloid deposition in human wild-type amyloid precursor protein YAC transgenic mice

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012-03-29 Biomarkers

    Genetically engineered mice have been generated to model cerebral β-amyloidosis, one of the hallmarks of Alzheimer disease (AD) pathology, based on the overexpression of a mutated cDNA of the amyloid-β precursor protein (AβPP) or by knock-in of the murine Aβpp gene alone or with presenilin1 mutations.

  3. Platelet immunoglobulin and amyloid precursor protein as potential peripheral biomarkers for Alzheimer's disease: findings from a pilot study

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Age and ageing 2012-01-17 Biomarkers

    Since cerebrospinal fluid analysis and molecular neuroimaging are not routinely used in many countries, blood biomarker molecules may be more readily applicable in a routine clinical setting.

  4. Mutations in amyloid precursor protein affect its interactions with presenilin/gamma-secretase

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Molecular and cellular neurosciences 2009-03-09 Biomarkers

    Alzheimer's disease is characterized by accumulation of toxic beta-amyloid (Abeta) in the brain and neuronal death.

  5. Cell-specific expression of beta-amyloid precursor protein isoform mRNAs and proteins in neurons and astrocytes

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Brain research. Molecular brain research 1997-07-01 Biomarkers

    The abnormal accumulation of beta-amyloid (A beta) in senile plaques appears to be a central pathological process in Alzheimer's disease.

  6. Beta-secretase processing of the beta-amyloid precursor protein in transgenic mice is efficient in neurons but inefficient in astrocytes

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Journal of biological chemistry 1996-12-01 Biomarkers

    Alzheimer's disease is characterized by the extracellular deposition of beta-amyloid peptide (Abeta) in cerebral plaques and evidence is accumulating that amyloid is neurotoxic.

  7. Aggregation of the amyloid precursor protein within degenerating neurons and dystrophic neurites in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neuroscience 1992-06-01 Biomarkers

    Using a monoclonal antibody raised against purified, native, human protease nexin-2/amyloid precursor protein, which recognizes an amino terminal epitope on the amyloid precursor protein and detects all major isoforms of amyloid precursor protein, we examined the localization of the amyloid precursor protein within Alzheimer's and aged control brains.

All topic tags with their study counts