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muscarinic
4 studies tagged muscarinic, dated 2000-12-01 to 2008-07-01. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- Cholinergic treatments with emphasis on m1 muscarinic agonists as potential disease-modifying agents for Alzheimer's disease 2008-07-01
- Treatment with the selective muscarinic m1 agonist talsaclidine decreases cerebrospinal fluid levels of A beta 42 in patients with Alzheimer's disease 2003-03-01
- M1 muscarinic agonists can modulate some of the hallmarks in Alzheimer's disease: implications in future therapy 2003-01-01
Studies
4 studies carry this tag.
Date range
2000 to 2008
Top journals
- Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 1
- Annals of neurology 1
- Journal of molecular neuroscience : MN 1
- Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 1
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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The only prescribed drugs for treatment of Alzheimer's disease (AD) are acetylcholinesterase inhibitors (e.g., donepezil, rivastigmine, galantamine, and tacrine) and memantine, an NMDA antagonist.
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The amyloid beta-peptides A beta 40 and A beta 42 are highly amyloidogenic constituents of brain beta-amyloid plaques in Alzheimer's disease (AD).
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M1 muscarinic receptors (M1 mAChRs) play a role in an apparent linkage of three major hallmarks of Alzheimer's disease (AD): beta-amyloid (Abeta) peptide; tau hyperphosphorylation and paired helical filaments (PHFs); and loss of cholinergic function conducive to cognitive impairments.
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beta-Amyloid (Abeta) deposits in diffuse and compact senile plaques in the brain are one of the defining histopathological features of Alzheimer's disease (AD).